Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 13 de 13
Filtrar
Más filtros

Bases de datos
País/Región como asunto
Tipo del documento
País de afiliación
Intervalo de año de publicación
1.
CJEM ; 21(2): 243-248, 2019 03.
Artículo en Inglés | MEDLINE | ID: mdl-29843840

RESUMEN

OBJECTIVES: Older adults make up a significant proportion of patients seeking care in the ED, with about 25% of these visits classified as "non-urgent." This study explored older adults' understandings, expectations of and self-reported reasons for seeking care and treatment provided in the ED. METHODS: This qualitative study involved semi-structured interviews with CTAS 4-5 patients conducted at randomly selected times and days during ED visits at three Saskatoon facilities in 2016. Thematic analysis was used to analyze interview data. RESULTS: 115 patients over age 65 years (mean age 79.1 years) were interviewed. While the majority had independently or with family made the decision to attend the ED, almost one-third of patients (31.6%) reported that they had been referred to the ED by general practitioners or specialists. Few respondents indicated the visit was the result of their general practitioner not being available. Most participants cited comprehensiveness and convenience of diagnostic and treatment services in a single location as the primary motivation for seeking treatment in the ED, which was especially important to those in poor health, without family supports, or with functional limitations, personal mobility and/or transportation challenges. Other common motivations were availability of after-hours care and perceived higher quality care compared to primary care. CONCLUSIONS: Accessibility to comprehensive care, availability, quality of care and positive past experiences were key considerations for older adults seeking treatment of non-urgent concerns. Older adults will likely continue to use EDs for non-urgent medical care until trusted, "one-stop" settings that better addresses the needs of this population are more widely available.


Asunto(s)
Servicio de Urgencia en Hospital , Accesibilidad a los Servicios de Salud , Necesidades y Demandas de Servicios de Salud , Accidentes por Caídas/estadística & datos numéricos , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Entrevistas como Asunto , Masculino , Dolor/epidemiología , Calidad de la Atención de Salud , Derivación y Consulta/estadística & datos numéricos , Saskatchewan/epidemiología , Heridas y Lesiones/epidemiología
2.
Poult Sci ; 93(2): 273-84, 2014 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-24570448

RESUMEN

Many emu farms are located in areas lacking processing facilities that can handle these birds. Thus, long-distance shipping of birds to an abattoir is necessary. Two experiments were conducted, wherein emus were transported in a modified horse trailer for 6 h to an abattoir. Changes in the indices of stress and metabolic homeostasis (hematology, serum biochemistry, enzymes, and body temperature and weight) were used to evaluate the physiological response to transport. The activities of enzymes alanine aminotransferase, aspartate aminotransferase, and creatine kinase increased significantly (P < 0.001) from pretransport to slaughter, indicating muscle cell wall damages. The body temperature of emus was significantly (P < 0.001) increased from 37.0 to 39.6°C after transport in experiment 1 and from 37.2 to 38.9°C in experiment 2. Transport resulted in significant weight loss in both experiments (P < 0.001; 2.1 ± 0.2 kg vs. 0.6 ± 0.2 kg) and posttransport resting at lairage led to slight regaining (P < 0.01) of BW. Oral administration of supplements before and after transport was effective in protecting against muscle damage and faster recovery of BW losses during lairage. The clinical findings were suggestive of the incidence of exertional rhabdomyolysis and thus underlined the need for careful handling and improved transport conditions of emus.


Asunto(s)
Dromaiidae , Rabdomiólisis/epidemiología , Rabdomiólisis/prevención & control , Aminoácidos/administración & dosificación , Aminoácidos/metabolismo , Alimentación Animal/análisis , Crianza de Animales Domésticos , Animales , Análisis Químico de la Sangre/veterinaria , Temperatura Corporal , Peso Corporal , Dieta/veterinaria , Suplementos Dietéticos/análisis , Electrólitos/administración & dosificación , Electrólitos/metabolismo , Enzimas/sangre , Femenino , Glucosa/administración & dosificación , Glucosa/metabolismo , Pruebas Hematológicas/veterinaria , Incidencia , Masculino , Rabdomiólisis/etiología , Rabdomiólisis/fisiopatología , Saskatchewan/epidemiología , Estrés Fisiológico , Transportes
3.
CMAJ ; 179(12): 1263-8, 2008 Dec 02.
Artículo en Inglés | MEDLINE | ID: mdl-19047607

RESUMEN

BACKGROUND: In previous studies, maternal exposure to folic acid antagonists was associated with increased risks of neural tube defects, cardiovascular defects, oral clefts and urinary tract defects. The objective of the current study was to assess the possible effects of using folic acid antagonists in pregnancy on placenta-mediated adverse outcomes of pregnancy. METHODS: We used data from an administrative database to retrospectively compare the occurrence of placenta-mediated adverse pregnancy outcomes between pregnant women exposed to folic acid antagonists and women without exposure to these agents. RESULTS: We included in the analysis a total of 14 982 women who had been exposed to folic acid antagonists and 59 825 women who had not been exposed. Sulfamethoxazole-trimethoprim was the most frequently prescribed dihydrofolate reductase inhibitor (a total of 12 546 exposures during the preconception period and all 3 trimesters), and phenobarbital was the most frequently prescribed among the other folic acid antagonists (a total of 1565 exposures). The risks of preeclampsia (adjusted odds ratio [OR] 1.52, 95% confidence interval [CI] 1.39-1.66), severe preeclampsia (OR 1.77, 95% CI 1.38-2.28), placental abruption (OR 1.32, 95% CI 1.12-1.57), fetal growth restriction defined as less than the 10th percentile (OR 1.07, 95% CI 1.01-1.13), fetal growth restriction defined as less than the 3rd percentile (OR 1.22, 95% CI 1.11-1.34) and fetal death (OR 1.35, 95% CI 1.07-1.70) were greater among mothers with exposure to folic acid antagonists. In general, the risks associated with exposure to other folic acid antagonists were higher than those associated with exposure to dihydrofolate reductase inhibitors. Supplementary analyses involving tight matching with propensity score, restriction of the analysis to women with exposure during the first and second trimesters and restriction of the analysis to specific categories of folic acid antagonists yielded similar results. INTERPRETATION: Maternal exposure to folic acid antagonists appears to increase the risk of placenta-mediated adverse outcomes of pregnancy.


Asunto(s)
Antagonistas del Ácido Fólico/efectos adversos , Placenta/efectos de los fármacos , Resultado del Embarazo/epidemiología , Desprendimiento Prematuro de la Placenta/inducido químicamente , Adulto , Estudios de Cohortes , Femenino , Muerte Fetal/inducido químicamente , Retardo del Crecimiento Fetal/inducido químicamente , Humanos , Exposición Materna/efectos adversos , Fenobarbital/efectos adversos , Preeclampsia/inducido químicamente , Embarazo , Estudios Retrospectivos , Saskatchewan/epidemiología , Combinación Trimetoprim y Sulfametoxazol/efectos adversos , Adulto Joven
4.
Spine (Phila Pa 1976) ; 33(4 Suppl): S170-5, 2008 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-18204389

RESUMEN

STUDY DESIGN: Ecological study. OBJECTIVES: To determine the annual incidence of hospitalized vertebrobasilar artery (VBA) stroke and chiropractic utilization in Saskatchewan and Ontario between 1993 and 2004. To determine whether at an ecological level, the incidence of VBA stroke parallels the incidence of chiropractic utilization. SUMMARY OF BACKGROUND DATA: Little is known about the incidence and time trends of VBA stroke diagnoses in the population. Chiropractic manipulation to the neck is believed to be a risk factor for VBA stroke. No study has yet found an association between chiropractic utilization and VBA diagnoses at the population level. METHODS: All hospitalizations with discharge diagnoses of VBA stroke were extracted from administrative databases for Saskatchewan and Ontario. We included incident cases that were diagnosed between January 1993 and December 2004 for Saskatchewan and from April 1993 to March 2002 for Ontario. VBA cases that had previously been hospitalized for any stroke or transient ischemic attack (TIA) were excluded. Chiropractic utilization was measured using billing data from Saskatchewan Health and Ontario Health Insurance Plan. Denominators were derived from Statistics Canada's annual population estimates. RESULTS: The incidence rate of VBA stroke was 0.855 per 100,000 person-years for Saskatchewan and 0.750 per 100,000 person-years for Ontario. The annual incidence rate spiked dramatically with a 360% increase for Saskatchewan in 2000. There was a 38% increase for the 2000 incidence rate in Ontario. The rate of chiropractic utilization did not increase significantly during the study period. CONCLUSION: In Saskatchewan, we observed a dramatic increase in the incidence rate in 2000 and there was a corresponding relatively small increase in chiropractic utilization. In Ontario, there was a small increase in the incidence rate; however, chiropractic utilization decreased. At the ecological level, the increase in VBA stroke does not seem to be associated with an increase in the rate of chiropractic utilization.


Asunto(s)
Enfermedad Iatrogénica/epidemiología , Manipulación Quiropráctica/efectos adversos , Manipulación Quiropráctica/estadística & datos numéricos , Accidente Cerebrovascular/epidemiología , Insuficiencia Vertebrobasilar/epidemiología , Adulto , Distribución por Edad , Causalidad , Quiropráctica/métodos , Quiropráctica/normas , Quiropráctica/estadística & datos numéricos , Estudios de Cohortes , Femenino , Humanos , Incidencia , Masculino , Manipulación Quiropráctica/normas , Persona de Mediana Edad , Dolor de Cuello/terapia , Ontario/epidemiología , Aceptación de la Atención de Salud/estadística & datos numéricos , Factores de Riesgo , Saskatchewan/epidemiología , Distribución por Sexo , Accidente Cerebrovascular/fisiopatología , Insuficiencia Vertebrobasilar/fisiopatología
5.
Arthritis Rheum ; 57(5): 861-8, 2007 Jun 15.
Artículo en Inglés | MEDLINE | ID: mdl-17530688

RESUMEN

OBJECTIVE: To test the reproducibility of the finding that early intensive care for whiplash injuries is associated with delayed recovery. METHODS: We analyzed data from a cohort study of 1,693 Saskatchewan adults who sustained whiplash injuries between July 1, 1994 and December 31, 1994. We investigated 8 initial patterns of care that integrated type of provider (general practitioners, chiropractors, and specialists) and number of visits (low versus high utilization). Cox models were used to estimate the association between patterns of care and time to recovery while controlling for injury severity and other confounders. RESULTS: Patients in the low-utilization general practitioner group and those in the general medical group had the fastest recovery even after controlling for important prognostic factors. Compared with the low-utilization general practitioner group, the 1-year rate of recovery in the high-utilization chiropractic group was 25% slower (adjusted hazard rate ratio [HRR] 0.75, 95% confidence interval [95% CI] 0.54-1.04), in the low-utilization general practitioner plus chiropractic group the rate was 26% slower (HRR 0.74, 95% CI 0.60-0.93), and in the high-utilization general practitioner plus chiropractic combined group the rate was 36% slower (HRR 0.64, 95% CI 0.50-0.83). CONCLUSION: The observation that intensive health care utilization early after a whiplash injury is associated with slower recovery was reproduced in an independent cohort of patients. The results add to the body of evidence suggesting that early aggressive treatment of whiplash injuries does not promote faster recovery. In particular, the combination of chiropractic and general practitioner care significantly reduces the rate of recovery.


Asunto(s)
Atención a la Salud/estadística & datos numéricos , Evaluación de Resultado en la Atención de Salud , Pautas de la Práctica en Medicina/estadística & datos numéricos , Reproducibilidad de los Resultados , Lesiones por Latigazo Cervical/rehabilitación , Adulto , Estudios de Cohortes , Femenino , Humanos , Masculino , Manipulación Quiropráctica , Visita a Consultorio Médico/estadística & datos numéricos , Atención Primaria de Salud , Saskatchewan/epidemiología , Lesiones por Latigazo Cervical/diagnóstico , Lesiones por Latigazo Cervical/epidemiología
6.
Can J Public Health ; 96(3): 201-5, 2005.
Artículo en Inglés | MEDLINE | ID: mdl-15913086

RESUMEN

BACKGROUND: It is well known that individuals receiving social assistance have more health problems than those with higher incomes. In this paper, we estimate the proportion of social assistance recipients who were on welfare following a drop in health status. METHODS: The study population consisted of Saskatchewan adults who had been continuously off social assistance for 12 consecutive months followed by 6 months on social assistance. Health status was measured by the use of physician services. We examined changes in physician service rates during the 18-month period. RESULTS: Forty-nine percent of individuals in the study population had increases in the number of physician services over the 18-month period. For these individuals, 53% of the increase in service use occurred during the 12 months prior to receiving social assistance. CONCLUSIONS: Deteriorating health, as measured by increased physician service use, seems to be one factor that precedes many people's receipt of welfare. A focus on improving health status may be one way to keep people off welfare.


Asunto(s)
Servicios de Salud/estadística & datos numéricos , Indicadores de Salud , Estado de Salud , Visita a Consultorio Médico/estadística & datos numéricos , Pobreza , Asistencia Pública/estadística & datos numéricos , Movilidad Social/economía , Bienestar Social/economía , Adolescente , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Programas Nacionales de Salud/estadística & datos numéricos , Médicos , Sistema de Registros , Saskatchewan/epidemiología , Factores Socioeconómicos
7.
Clin J Pain ; 21(2): 166-74, 2005.
Artículo en Inglés | MEDLINE | ID: mdl-15722810

RESUMEN

OBJECTIVES: To assess the effectiveness of multidisciplinary rehabilitation in the treatment of fibromyalgia in comparison to standard medical care. METHODS: Seventy-nine men and women were randomly assigned to one of two groups. The intervention group consisted of a rheumatologist and physical therapist intake and discharge, 18 group supervised exercise therapy sessions, 2 group pain and stress management lectures, 1 group education lecture, 1 group dietary lecture, and 2 massage therapy sessions. The control group consisted of standard medical care with the patients' family physician. Outcome measures included self-perceived health status, pain-related disability, average pain intensity, depressed mood, days in pain, hours in pain, prescription and nonprescription medication usage, and work status. Outcomes were measured at the end of the 6-week intervention and at 15-month follow-up. RESULTS: Thirty-five out of 43 patients from the intervention group and 36 out of 36 patients from the control group completed the study. There were no statistically significant differences between the 2 groups prior to intervention. Intention-to-treat analysis revealed that the intervention group, in comparison to the control group, experienced statistically significant changes at intervention completion in self-perceived health status, average pain intensity, pain related disability, depressed mood, days in pain, and hours in pain, but no significant differences in nonprescription drug use, prescription drug use, or work status. At 15 months, all health outcomes retained their significance except health status. Nonprescription and prescription drug use demonstrated significant reductions at 15 months. Binary logistic regression indicated that long-term changes in Pain Disability Index were influenced by long-term exercise adherence and income status. CONCLUSIONS: Positive health-related outcomes in this mostly unresponsive condition can be obtained with a low-cost, group multidisciplinary intervention in a community-based, nonclinical setting.


Asunto(s)
Servicios de Salud Comunitaria/estadística & datos numéricos , Fibromialgia/epidemiología , Fibromialgia/rehabilitación , Evaluación de Resultado en la Atención de Salud/métodos , Dolor/epidemiología , Dolor/rehabilitación , Terapia Combinada , Dietoterapia/estadística & datos numéricos , Terapia por Ejercicio/estadística & datos numéricos , Femenino , Fibromialgia/diagnóstico , Humanos , Masculino , Persona de Mediana Edad , Dolor/diagnóstico , Clínicas de Dolor/estadística & datos numéricos , Educación del Paciente como Asunto , Modalidades de Fisioterapia/estadística & datos numéricos , Calidad de Vida , Saskatchewan/epidemiología , Índice de Severidad de la Enfermedad , Resultado del Tratamiento
8.
Spine (Phila Pa 1976) ; 28(3): 299-304, 2003 Feb 01.
Artículo en Inglés | MEDLINE | ID: mdl-12567037

RESUMEN

STUDY DESIGN: A retrospective and prospective cohort. OBJECTIVES: To compare the effectiveness of occupational intervention, early intervention, and standard care in the management of Worker's Compensation injury claims. SUMMARY OF BACKGROUND DATA: The current management of occupational back pain and work-related upper extremity disorders with either standard care or early intervention appears to be ineffective. METHODS: A retrospective cohort compared injury claim incidence, duration, and costs between one company with access to standard care and another similar company with access to early intervention. A prospective cohort looked at the effect of one company changing from standard care to occupational management in comparison with the control group with early intervention. Survival analysis was used to attempt to explain differences in injury claim duration. RESULTS: Standard care resulted in lower injury claim incidence, duration, and costs than early intervention, whereas occupational management resulted in lower injury claim incidence, duration, and costs than standard care. The covariates of physical therapist involvement, chiropractor involvement, injury severity, and relationship between Worker's Compensation and the employer were associated with delayed time to claim closure in the company with access to early intervention with the most important covariate being physical therapist involvement (hazard rate ratio 19.88, 95% confidence interval 7.95-39.77). Only the covariate of injury severity was associated with delayed time to claim closure in the company with access to occupational management (hazard rate ratio 1.67, 95% confidence interval 1.05-27.20). CONCLUSIONS: It is recommended that an occupational management approach, in comparison with standard care or early intervention, be considered for management of occupational injuries.


Asunto(s)
Manejo de la Enfermedad , Enfermedades Profesionales/rehabilitación , Servicios de Salud del Trabajador/normas , Evaluación de Resultado en la Atención de Salud , Indemnización para Trabajadores/estadística & datos numéricos , Accidentes de Trabajo/economía , Accidentes de Trabajo/estadística & datos numéricos , Dolor de Espalda/economía , Dolor de Espalda/epidemiología , Dolor de Espalda/rehabilitación , Estudios de Cohortes , Comorbilidad , Evaluación de la Discapacidad , Humanos , Incidencia , Industrias/estadística & datos numéricos , Manipulación Quiropráctica/economía , Manipulación Quiropráctica/estadística & datos numéricos , Enfermedades Profesionales/economía , Enfermedades Profesionales/epidemiología , Servicios de Salud del Trabajador/economía , Modalidades de Fisioterapia/economía , Modalidades de Fisioterapia/estadística & datos numéricos , Estudios Prospectivos , Estudios Retrospectivos , Saskatchewan/epidemiología , Análisis de Supervivencia , Indemnización para Trabajadores/economía
9.
BMC Complement Altern Med ; 2: 7, 2002 Jul 02.
Artículo en Inglés | MEDLINE | ID: mdl-12095423

RESUMEN

BACKGROUND: Many patients use alternative therapies. The purpose of this study was to determine the percentage of stroke rehabilitation patients in Saskatchewan using alternative therapies, whether patients found these therapies effective in alleviating stroke-related symptoms, how often those patients who used alternative therapies discuss this fact with their primary care doctor and the main reason why patients might not do so. METHODS: Telephone questionnaire surveys were conducted with 117 patients who had suffered a stroke and undergone inpatient or outpatient rehabilitation at Saskatoon City Hospital. RESULTS: The study revealed that 26.5% of 117 stroke rehabilitation patients visited alternative practitioners at least once or used some form of unconventional therapy. Only 16.1% of patients found that alternative therapy made them feel much better. Of those who used alternative therapy, 61.3% did not discuss this fact with their primary physician. Many of the respondents (47.3%) who did not inform their physician stated that they did not see the necessity of talking about these treatments and 21.1% did not discuss the issue with their physician because they felt that he or she might disapprove of alternative therapies. CONCLUSION: A relatively small percentage of stroke patients found alternative therapies beneficial. Doctors should be aware that a significant number of patients will try alternative treatment without discussion with their primary care physician or specialist. The current study suggests that after completing routine questioning, doctors should also ask their patients about their use of alternative therapies and, when appropriate, review issues of safety and efficacy.


Asunto(s)
Terapias Complementarias/estadística & datos numéricos , Conocimientos, Actitudes y Práctica en Salud , Rehabilitación de Accidente Cerebrovascular , Accidente Cerebrovascular/terapia , Adulto , Anciano , Anciano de 80 o más Años , Actitud Frente a la Salud , Terapias Complementarias/economía , Análisis Costo-Beneficio , Femenino , Humanos , Masculino , Persona de Mediana Edad , Vigilancia de la Población , Prevalencia , Saskatchewan/epidemiología , Prevención Secundaria , Accidente Cerebrovascular/epidemiología
10.
Med Care ; 39(9): 956-67, 2001 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-11502953

RESUMEN

BACKGROUND: Neck and low back pain are leading causes of morbidity and health care utilization. However, little is known about the characteristics that differentiate those who seek from those who do not seek health care for their pain. OBJECTIVES: The objectives of this study were to: 1) describe health care utilization for neck and back pain; 2) determine the characteristics of individuals seeking health care for neck and back pain; and 3) identify the characteristics of patients who consult medical doctors, chiropractors, or both. DESIGN: Population-based cross-sectional mailed survey. SUBJECTS: Subjects were randomly selected adults from the Saskatchewan Health Insurance and Registration File. MEASURES: Demographic, socio-economic, general health, comorbidity, health-related-quality-of-life, pain severity and health care utilization data were collected. The main outcome was whether subjects with prevalent neck or low back pain visited a health care provider in the previous month. RESULTS: Twenty-five percent of individuals with neck or low back pain visited a health care provider. Seeking health care was associated with disabling neck or back pain, digestive disorders, worse bodily pain and worse physical-role-functioning. Compared with medical patients, fewer chiropractic patients lived in rural areas or reported arthritis, but they reported better social and physical functioning. More patients consulting both providers reported disabling neck or back pain. CONCLUSIONS: Individuals seeking care for neck or back pain have worse health status than those who do not seek care. Patients consulting chiropractors alone report fewer comorbidities and are less limited in their activities than those consulting medical doctors.


Asunto(s)
Servicios de Salud/estadística & datos numéricos , Dolor de la Región Lumbar/terapia , Dolor de Cuello/terapia , Aceptación de la Atención de Salud/estadística & datos numéricos , Revisión de Utilización de Recursos , Adulto , Quiropráctica/estadística & datos numéricos , Comorbilidad , Estudios Transversales , Femenino , Encuestas de Atención de la Salud , Humanos , Modelos Logísticos , Dolor de la Región Lumbar/epidemiología , Masculino , Medicina/estadística & datos numéricos , Persona de Mediana Edad , Dolor de Cuello/epidemiología , Calidad de Vida , Saskatchewan/epidemiología , Factores Socioeconómicos , Especialización
11.
Can J Public Health ; 91(6): 449-53, 2000.
Artículo en Inglés | MEDLINE | ID: mdl-11200737

RESUMEN

OBJECTIVE: We examined the factors related to consultations with both physicians and alternative practitioners, compared with visits to physicians only. METHODS: A telephone survey (random-digit dialling) collected information from 818 adults living in and around Saskatoon. Respondents reported consultations with alternative practitioners and physicians in the previous 12 months. RESULTS: Approximately one in five respondents had consulted both a physician and an alternative practitioner. Among respondents under 65 years of age, having one or more chronic medical conditions significantly increased the likelihood of concurrent use of care. Men, individuals suffering from back pain or migraines, those reporting an elevation level of distress, and those for whom spiritual values were important were also more likely to use both types of care. INTERPRETATION: Consultations with alternative care providers occur as an adjunct to, rather than a replacement of visits to physicians. Particular types of medical conditions as well as psychosocial and spiritual factors are determinants of concurrent use of physicians and alternative practitioners.


Asunto(s)
Terapias Complementarias/estadística & datos numéricos , Aceptación de la Atención de Salud/estadística & datos numéricos , Médicos/estadística & datos numéricos , Derivación y Consulta/estadística & datos numéricos , Adulto , Anciano , Enfermedad Crónica/clasificación , Demografía , Femenino , Estado de Salud , Salud Holística , Humanos , Masculino , Persona de Mediana Edad , Visita a Consultorio Médico , Aceptación de la Atención de Salud/psicología , Saskatchewan/epidemiología
12.
Am J Epidemiol ; 139(7): 670-83, 1994 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-8166128

RESUMEN

The association between the occurrence of carcinoma of the breast and previous usage of menopausal estrogens, progestins, and oral contraceptives is examined in a record-linkage study using the Saskatchewan Health Prescription-Drug-Plan Database. Saskatchewan Health is a governmental agency that funds publicly insured health care for essentially all residents of the province. For this study, all women aged 43-49 years in 1976 resident in Saskatchewan were identified from the Saskatchewan Health master registration file. These women were linked by registration beneficiary number to the Drug-Plan Database for the period from January 1976 to June 1987 and to the Provincial Cancer Registry Database for the period from March 1960 to December 1990. The fact and date of death or emigration from the province were obtained through the annual updates of the health plan. Of the 33,003 women initially in the cohort, 213 had a breast cancer diagnosed before 1976 and were omitted from this analysis. Between 1976 and 1990, 742 new primary breast cancer cases occurred. Women taking estrogens unopposed by progestins had an elevated risk of breast cancer, the risk increasing by 7% (relative risk = 1.072, 95% confidence interval 1.02-1.13; p = 0.008) for each 252 tablets used (approximately 1 year of use). Usage of estrogens opposed by progestins showed no association with risk (p = 0.48). Women taking oral contraceptives during this follow-up period also had a higher risk, increasing by 14% (relative risk = 1.144, 95% confidence interval 1.05-1.24; p = 0.002) for every 252 tablets used. These 1-year risk elevations are small but become appreciable at longer durations. For example, at 5 years of unopposed estrogen use, the relative risk is 1.42; for 5 years of oral contraceptive use, it is 1.96.


Asunto(s)
Neoplasias de la Mama/epidemiología , Estrógenos/efectos adversos , Posmenopausia , Adulto , Neoplasias de la Mama/inducido químicamente , Estudios de Cohortes , Anticonceptivos Orales Combinados/administración & dosificación , Terapia de Reemplazo de Estrógeno/efectos adversos , Femenino , Humanos , Incidencia , Persona de Mediana Edad , Programas Nacionales de Salud , Progesterona/administración & dosificación , Progestinas/administración & dosificación , Estudios Prospectivos , Sistema de Registros , Riesgo , Saskatchewan/epidemiología
13.
Health Phys ; 60(4): 489-95, 1991 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-2001944

RESUMEN

A nested case-control study within the Beaverlodge Uranium Miners Cohort was undertaken to assess any possible contribution of confounding by smoking and other mining experience to the risk estimate derived from the original cohort study. Next of kin have been interviewed for 46 lung cancer cases and 95 controls enrolled in the Beaverlodge Uranium Miners Cohort Study who died between 1950 and 1980. Confounding by cigarette smoking and other mining experience appears unlikely to have contributed to the relative risk coefficient for exposure to Rn decay products derived in the parent study. Data for smoking and exposure to Rn decay products are consistent with a multiplicative model, although considerable caution must be applied to this interpretation.


Asunto(s)
Neoplasias Pulmonares/epidemiología , Minería , Neoplasias Inducidas por Radiación/epidemiología , Exposición Profesional , Radón , Fumar/epidemiología , Uranio , Estudios de Casos y Controles , Estudios de Cohortes , Riesgo , Saskatchewan/epidemiología
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA