Asunto(s)
Preparaciones de Acción Retardada , Evaluación Preclínica de Medicamentos/normas , Implantes de Medicamentos , Proyectos de Investigación/normas , Stents , Angiografía/normas , Animales , Técnicas de Cultivo de Célula , Materiales Biocompatibles Revestidos/normas , Conferencias de Consenso como Asunto , Enfermedad de la Arteria Coronaria/patología , Enfermedad de la Arteria Coronaria/terapia , Preparaciones de Acción Retardada/efectos adversos , Preparaciones de Acción Retardada/farmacocinética , Preparaciones de Acción Retardada/normas , Modelos Animales de Enfermedad , Relación Dosis-Respuesta a Droga , Implantes de Medicamentos/efectos adversos , Implantes de Medicamentos/farmacocinética , Implantes de Medicamentos/normas , Oclusión de Injerto Vascular/etiología , Oclusión de Injerto Vascular/prevención & control , Humanos , Arteria Ilíaca , Inhibidores de Agregación Plaquetaria/uso terapéutico , Conejos , Stents/efectos adversos , Stents/clasificación , Stents/normas , Porcinos , Trombosis/prevención & control , Fijación del TejidoRESUMEN
PURPOSE: We report the procedural details and immediate results of treatment of type II endoleaks after aortic stent-graft implantation. METHODS: In a consecutive series of patients who had either Vangard (n = 53) or Talent (n = 7) aortic stent-grafts implanted, type II endoleaks were confirmed by means of angiography in 18 patients, with a mean (+/- SD) age of 69 +/- 11 years; 16 patients had Vangard stent-grafts, and two patients had Talent stent-grafts. After superselective catheterization of the feeding vessel, with 3F microcatheters, and liberal injections of vasodilators, embolization was performed with either a mixture of biologic glue and Lipiodol (n = 16) or Microcoils (n = 2). RESULTS: The procedure was performed through the femoral artery in 16 patients and through the brachial artery in the remaining two patients. Overall, superselective catheterization and embolization were successfully undertaken in 17 (94.4%) of 18 patients. In the remaining patient, superselective catheterization proved impossible. This patient was treated with an injection of microparticles completed by means of embolization of biologic glue more proximally in an iliolumbar branch. During follow-up (mean, 13.3 months) after embolization, the aneurysm sac shrank in 13 (72.2%) of 18 patients. A new type II endoleak was diagnosed on helical computed tomography or magnetic resonance imaging in two (11.1%) of 18 patients. CONCLUSION: Percutaneous embolization is a safe and effective technique for treatment of type II endoleaks. However, despite these initially promising results, large long-term follow-up studies will be required to confirm its efficiency.