Pharmacokinetics and therapeutic potential for repeated oral doses of trimethoprim/sulphachlorpyridazine in horses.

The pharmacokinetic parameters of a powder formulation of trimethoprim/sulphachlorpyridazine were studied in eight healthy horses which received 5 mg/kg trimethoprim and 25 mg/kg sulphachlorpyridazine 12-hourly with concentrate for five days. The intake of the medicated concentrate by the horses was variable during the first two days, but after they became accustomed to the taste the intake by all the horses during the last three days was good. Faecal samples taken before and on the last day of the drug administrations were negative when cultured for salmonella. Compared with the results of a previous single-dose experiment, higher plasma concentrations and a higher area under the curve for both the drugs were observed. The repeated doses provided plasma concentrations above the minimal inhibitory concentration for Streptococcus zooepidemicus, S equi, Actinobacillus equuli and Rhodococcus equi isolated from the respiratory tract of horses. Synergism between the two drugs occurred at different drug concentration ratios with different bacterial species.

[Action of sodium sulfachlorpyrazine (ESB3) on the endogenous development of Eimeria tenella in the experimental infestation of chickens]. / Prouchvane deistvieto na sulfakhlorpirazin-natriia (ESB3) vurkhu endogennoto razvitie na Eimeria tenella pri eksperimentalna invaziia na pileta.

Studies were carried out on the action of sulfachlorpyrisine-Na (ESB3) on the endogenic development of Eimeria tenella in the case of experimental infection in birds. Most sensitive to the preparation were the endogenic forms between the 48 h and the 72 nd following the act of infection. Given to birds on the day of infection and 24 hours later it produced no harmful effect on the further endogenic development of E. tenella. When the preparation was applied at the 72 nd hour it led to the degeneration of most of the II generation schizonts and inhibited their further development. As a result no oocysts were found in the feces of birds up to the 10 th-11 th day after infection. When applied at the 92 nd and the 120 th hour sulfachlorpyrisine-Na interfered with the development of the already finite forms of gametogony without concurrent degenerative effects.

[Chemoprophylaxis and therapy of coccidiosis in the rock partridge, Alectoris graeca cypriatis]. / Khimioprofilaktika i terapiia na koktsidiozata po keklitsite Alektoris graeca cypriatis.

A number of coccidiostatica--amprolium (Merek Sharp & Dohme), both for the prevention and treatment, DOT Solubile (By-Gulden) and Esb3 (Ciba Geigy) for treatment--were tested with artificially raised rock partridges on an infected farm. The trials were carried out with a total of 12300 young (12-day-old) birds suffering from spontaneous outbreaks of coccidiosis and 60 such birds with experimental coccidiosis. The comparative study on the results obtained revealed that amprolium produced a good prophylactic effect and a low therapeutic one in cases of clinical coccidioses, used at the rate of 125 mg/kg and offered with the forage mixture. DOT at 30 g/10 1 of water had a pronounced therapeutic effect in the course of 5 days. The preparation Esb3 at the rate of 1 g per one liter of water for 3 days was tested in experimentally induced coccidiosis (E. kofoidi). It produced good therapeutic effects with the highest coccidiosis index ever noted on the second day following infection. It can be applied on occasions of E. kofoidi-induced coccidiosis.