RESUMEN
A literature review of cases of acute poisoning by copper sulfate was conducted, emphasizing therapeutic interventions, and a new fatality case is reported. Specifically, the relevant literature was reviewed for incidence rates, sociodemographic variables, pathophysiology, diagnosis, prognosis, and therapeutic outcome of copper sulfate poisoning. Results conclude that copper sulfate poisoning incidence varies in different regions. It is rare in western countries, while it is very common in South Asian countries. The majority of patients belong to rural populations and are males in the third decade of their lives. The lethal dose of ingested copper is considered to be 10-20 g; 14-36% of the patients pass away within a few hours of ingestion, while the average hospitalization time is more than 20 days. The clinical features of copper sulfate poisoning include erosive gastropathy, intravascular hemolysis, methemoglobinemia, hepatitis, and acute kidney injury. The therapeutic management focuses on absorption reduction, close observation for complications, supportive therapy, and chelation therapy.
Asunto(s)
Sulfato de Cobre/envenenamiento , Plaguicidas/envenenamiento , Anciano de 80 o más Años , Humanos , Masculino , Estómago , SuicidioAsunto(s)
Sulfato de Cobre/envenenamiento , Eritrocitos Anormales/efectos de los fármacos , Hemólisis/efectos de los fármacos , Metahemoglobinemia/inducido químicamente , Adulto , Terapia por Quelación , Sulfato de Cobre/farmacología , Eritrocitos Anormales/enzimología , Eritrocitos Anormales/ultraestructura , Glucosafosfato Deshidrogenasa/antagonistas & inhibidores , Glutatión Reductasa/antagonistas & inhibidores , Humanos , Leucocitosis/inducido químicamente , Masculino , Rabdomiólisis/inducido químicamente , ATPasa Intercambiadora de Sodio-Potasio/antagonistas & inhibidoresRESUMEN
Voluntary copper poisoning is a rare mode of suicide. We report a case of copper sulphate poisoning in a patient presenting delusions with mystic demands for purification. The initial gastrointestinal symptoms were followed by intravascular haemolysis and renal failure. The course was favourable after symptomatic treatment and specific copper chelation therapy. However, the pathogenesis is not fully understood and with the present state of knowledge, no one treatment can be said to be superior to another. The authors discuss the various treatments of this rare poisoning through a review of the available literature.
Asunto(s)
Sulfato de Cobre/envenenamiento , Intoxicación/diagnóstico , Intoxicación/terapia , Adulto , Quelantes/uso terapéutico , Humanos , Masculino , Intoxicación/psicología , Intento de SuicidioRESUMEN
CASE REPORT: An 86-year-old woman accidentally ingested a preparation containing zinc and copper sulfate. At ninety minutes after ingestion, the peak plasma concentration was 1979 micrograms/dL for zinc and 209 micrograms/dL for copper, suggesting preferential absorption of zinc. The major complications were gastric and bronchial inflammation due to the corrosive properties of these compounds. Systemic manifestations also developed with cardiovascular failure and renal insufficiency, but the patient made a complete recovery. In addition to symptomatic treatment, chelation therapy with dimercaprol and D-penicillamine was given for 48 h. CONCLUSION: The available clinical and toxicokinetic data do not support the benefits of chelation in addition to supportive therapy.