RESUMEN
BACKGROUND: Skin's exposure to intrinsic and extrinsic factors causes age-related changes, leading to a lower amount of dermal collagen and elastin. AIM: This study investigated the effects of a novel facial muscle stimulation technology combined with radiofrequency (RF) heating on dermal collagen and elastin content for the treatment of facial wrinkles and skin laxity. METHODS: The active group subjects (N = 6) received four 20-min facial treatments with simultaneous RF and facial muscle stimulation, once weekly. The control subject (N = 1) was untreated. Skin biopsies obtained at baseline, 1-month and 3-month follow-up were evaluated histologically to determine collagen and elastin fibers content. A group of independent aestheticians evaluated facial skin appearance and wrinkle severity. Patient safety was followed. RESULTS: In the active group, collagen-occupied area reached 11.91 ± 1.80 × 106 µm2 (+25.32%, p < 0.05) and 12.35 ± 1.44 × 105 µm2 (+30.00%, p < 0.05) at 1-month and 3-month follow-up visits. Elastin-occupied area at 1-month and 3-month follow-up was 1.64 ± 0.14 × 105 µm2 (+67.23%, p < 0.05), and 1.99 ± 0.21 × 105 µm2 (+102.80%, p < 0.05). In the control group, there was no significant difference (p > 0.05) in collagen and elastin fibers. Active group wrinkle scores decreased from 5 (moderate, class II) to 3 (mild, class I). All subjects, except the control, improved in appearance posttreatment. No adverse events or side effects occurred. CONCLUSION: Decreased dermal collagen and elastin levels contributes to a gradual decline in skin elasticity, leading to facial wrinkles and unfirm skin. Study results showed noticeable improvement in facial appearance and increased dermal collagen and elastin content subsequent to simultaneous, noninvasive RF, and facial muscle stimulation treatments.
Asunto(s)
Colágeno , Elastina , Músculos Faciales , Envejecimiento de la Piel , Humanos , Elastina/análisis , Elastina/metabolismo , Envejecimiento de la Piel/efectos de la radiación , Colágeno/metabolismo , Colágeno/análisis , Femenino , Persona de Mediana Edad , Adulto , Músculos Faciales/efectos de la radiación , Terapia por Radiofrecuencia/métodos , Terapia por Radiofrecuencia/efectos adversos , Masculino , Terapia por Estimulación Eléctrica/efectos adversos , Terapia por Estimulación Eléctrica/instrumentación , Terapia por Estimulación Eléctrica/métodos , Técnicas Cosméticas/efectos adversos , Técnicas Cosméticas/instrumentación , Piel/efectos de la radiación , Piel/patología , Cara , Biopsia , Resultado del TratamientoRESUMEN
BACKGROUND: Radiofrequency (RF) and high-intensity focused electromagnetic (HIFEM) technologies are used for noninvasive body shaping as standalone modalities. OBJECTIVE: To examine the effects of novel synchronized RF and HIFEM on subcutaneous adipose tissue in a porcine animal model. MATERIALS AND METHODS: Seven large white pigs aged 6 months received 3 abdominal treatments of simultaneous application of synchronized RF and HIFEM (30 minutes, once per week). Punch biopsies of treated and control subcutaneous tissue were collected at the baseline, 4 days, 2 weeks, 1 month, and 2 months. Specimens were examined by light and scanning electron microscopy. Adipocyte volume was analyzed. Fat tissue temperature was measured in situ (fiber optic probes) and superficially (thermal imager). RESULTS: Fat layer was heated to temperatures of 42 to 45°C. Signs of fat apoptosis (shape alternations and pyknotic nuclei) appeared at day 4 and peaked between 2 weeks and 1 month. Adipocyte volume decreased significantly (p < .001) by 31.1% at 2 weeks, 1 month (-23.6%), and 2 months (-22.0%). Control samples showed healthy adipocytes. Scanning electron microscopy micrographs corroborated histology findings, showing flattened, volume-depleted and disrupted adipocytes. CONCLUSION: Synchronized RF with HIFEM procedure resulted in a significant and sustained fat reduction with no adverse events.
Asunto(s)
Contorneado Corporal/métodos , Magnetoterapia/métodos , Terapia por Radiofrecuencia/métodos , Grasa Subcutánea/efectos de la radiación , Adipocitos/efectos de la radiación , Adipocitos/ultraestructura , Animales , Contorneado Corporal/efectos adversos , Contorneado Corporal/instrumentación , Terapia Combinada/instrumentación , Terapia Combinada/métodos , Femenino , Calor/efectos adversos , Magnetoterapia/efectos adversos , Magnetoterapia/instrumentación , Microscopía Electrónica , Modelos Animales , Terapia por Radiofrecuencia/efectos adversos , Terapia por Radiofrecuencia/instrumentación , Grasa Subcutánea/citología , Grasa Subcutánea/ultraestructura , PorcinosRESUMEN
BACKGROUND: Radiofrequency and high-Intensity Focused Electromagnetic (HIFEM) field procedure are well-known, stand-alone, body-shaping modalities, yet their simultaneous application has not been investigated. OBJECTIVE: The aim is to evaluate the efficacy of a novel device simultaneously delivering HIFEM and radiofrequency for subcutaneous fat reduction and muscle toning. MATERIALS AND METHODS: Forty-one subjects with an average age of 39.7 ± 11.5 years were recruited. The subjects received 3 abdominal treatments (one per week). Magnetic resonance imaging images of the treated area were evaluated at baseline and at 1-, 3-, and 6-month visits for changes in subcutaneous fat, muscle thickness, and abdominal separation (AS). Anthropometric data and digital photographs were collected. Subject satisfaction and therapy comfort were evaluated. RESULTS: The muscle mass increase peaked at 3 months, showing 26.1% thickening. The fat thickness reduction was most prominent at 3 months, showing a 30.8% reduction. The AS decreased by 18.8% at 3 months after treatment. The waist circumference reduced by 5.87 ± 3.64 cm at a 3-month follow-up. Six-month data showed maintenance of these outcomes. The treatment was considered as comfortable with high patient satisfaction. CONCLUSION: The analysis of magnetic resonance imaging images and waist measurements showed that the therapy combining HIFEM and radiofrequency is highly effective in reducing subcutaneous fat and muscle thickening.
Asunto(s)
Grasa Abdominal , Contorneado Corporal/métodos , Magnetoterapia , Tono Muscular , Terapia por Radiofrecuencia , Grasa Abdominal/diagnóstico por imagen , Adulto , Contorneado Corporal/efectos adversos , Femenino , Humanos , Magnetoterapia/efectos adversos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Terapia por Radiofrecuencia/efectos adversos , Resultado del TratamientoRESUMEN
BACKGROUND: Skin rejuvenation can be achieved with minimally invasive treatments using energy-based devices that feature reduced side effects and downtime. Post-treatment care is key to minimize any potential side effects and skin reactions such as erythema, dryness, or dyschromia. OBJECTIVE: The objective of this study was to evaluate the efficacy and patient satisfaction of a novel carboxytherapy gel mask compared with petroleum-based lanolin-containing ointment to accelerate wound healing facial post-nanofractional radiofrequency treatment. METHODS AND MATERIALS: Ten subjects were enrolled in this pilot, prospective, randomized, single-blind study and randomized into two arms. One arm received one nanofractional radiofrequency treatment with ointment right after and four consecutive days of ointment applications twice a day, while the second arm followed this regimen with a carboxytherapy gel mask application right after and four consecutive days after treatment. Investigator, safety, and patient assessments were conducted at 24 hours and one-week post treatment. Safety was monitored throughout. The primary endpoint was defined as the degree of investigator global assessment (IGA) in photodamage, pigmentation, and wrinkles using standardized photographs. Secondary endpoints included investigator-rated degree of erythema, edema, crusting, exudation, percentage healing, improvement of skin quality, and patient satisfaction. RESULTS: Nine patients completed the study. There was improvement of one degree in IGA for photodamage, pigmentation and wrinkles in all patients using the carboxytherapy gel mask at the one-week follow up. Blinded investigator ratings showed significant improvement of dryness, erythema, edema, crusting, and percentage healing at the 24-hour follow up, with all patients remaining the same a week post treatment. All patients in the carboxytherapy group were satisfied with the treatment and had no adverse effects. Three patients in the petroleum-based lanolin-containing group experienced mild edema and acne breakout that resolved two weeks after treatment. CONCLUSION: Carboxytherapy delivered via a gel mask after skin rejuvenation procedures is a safe and effective strategy to improve clinical outcomes and reduce post-treatment side effects. J Drugs Dermatol. 20(4):461-465. doi:10.36849/JDD.5856.
Asunto(s)
Dióxido de Carbono/administración & dosificación , Técnicas Cosméticas/efectos adversos , Eritema/tratamiento farmacológico , Terapia por Radiofrecuencia/efectos adversos , Rejuvenecimiento , Administración Cutánea , Adulto , Eritema/diagnóstico , Eritema/etiología , Cara , Femenino , Geles , Humanos , Lanolina/administración & dosificación , Persona de Mediana Edad , Pomadas/administración & dosificación , Pomadas/química , Satisfacción del Paciente , Petróleo , Fotograbar , Proyectos Piloto , Estudios Prospectivos , Hipofraccionamiento de la Dosis de Radiación , Terapia por Radiofrecuencia/métodos , Índice de Severidad de la Enfermedad , Método Simple Ciego , Piel/diagnóstico por imagen , Piel/efectos de los fármacos , Piel/efectos de la radiación , Envejecimiento de la Piel/efectos de la radiación , Resultado del TratamientoRESUMEN
BACKGROUND: Many studies have evaluated radiofrequency microneedling (RFMN) in various dermatologic conditions. However, the efficacy and safety of RFMN, and how it compares with other energy-based devices in a clinician's armamentarium, remains unclear. OBJECTIVE: To review higher-quality evidence supporting RFMN and the dermatologic conditions which it can be used in. MATERIALS AND METHODS: A search was conducted in MEDLINE and EMBASE from inception to May 13, 2020, using the terms: "radiofrequency microneedling" OR "fractional radiofrequency" OR "radiofrequency needling" OR "radiofrequency percutaneous collagen induction." Only randomized, split body or blinded studies with original data on humans were included. Non-English or non-dermatology-related studies were excluded. RESULTS: Forty-two higher-quality studies were included after applying the inclusion and exclusion criteria. There were 14 studies for skin rejuvenation, 7 for acne scars, 6 for acne vulgaris, 5 each for striae and axillary hyperhidrosis, 2 for melasma, and 1 each for rosacea, cellulite, and androgenetic alopecia. CONCLUSION: Radiofrequency microneedling is an effective intervention that can be used repeatedly and safely in combination with other treatment modalities and in individuals with darker skin phototypes. Radiofrequency microneedling-induced dermal remodeling and neocollagenesis are slow and progressive but continue to improve even 6 months after treatment.
Asunto(s)
Técnicas Cosméticas , Punción Seca/métodos , Terapia por Radiofrecuencia/métodos , Acné Vulgar/terapia , Cicatriz/terapia , Colágeno/biosíntesis , Punción Seca/efectos adversos , Punción Seca/instrumentación , Humanos , Hiperhidrosis/terapia , Agujas/efectos adversos , Terapia por Radiofrecuencia/efectos adversos , Terapia por Radiofrecuencia/instrumentación , Rejuvenecimiento , Piel/metabolismo , Piel/efectos de la radiación , Envejecimiento de la Piel/efectos de la radiación , Pigmentación de la Piel , Resultado del TratamientoRESUMEN
BACKGROUND: Fractional microneedle radiofrequency (FMRF) systems are popular options for treating acne scars. However, treatment efficacy when used in combination with traditional ablative fractional laser (AFL) and the safety profile with concomitant use of isotretinoin remain unknown. OBJECTIVE: The aim of this study was to assess the safety and efficacy of an early intervention combination treatment protocol for inflammatory acne and acne scars. MATERIALS AND METHODS: The electronic records of 71 patients with inflammatory acne and acne scars were included in this retrospective observational study. Data were collected for all patients who received combination FMRF and AFL. Within the study group, 43 patients were receiving low-dose isotretinoin or had completed isotretinoin within the past 3 weeks. RESULTS: The mean Scar Global Assessment score significantly decreased after 3 sessions of combination treatment (n = 71). Patients with inflammatory acne showed a significant decrease in the number of inflammatory lesions (n = 30). Patients with concomitant low-dose isotretinoin use reported a further decrease in Scar Global Assessment score (n = 43). There were no reported persistent side effects, including prolonged inflammatory reaction or scarring. CONCLUSION: Combination treatment with FMRF and AFL is an effective and well-tolerated treatment modality for acne scars and inflammatory acne.
Asunto(s)
Acné Vulgar/terapia , Cicatriz/terapia , Punción Seca/métodos , Isotretinoína/administración & dosificación , Terapia por Láser/métodos , Terapia por Radiofrecuencia/efectos adversos , Acné Vulgar/complicaciones , Acné Vulgar/diagnóstico , Administración Oral , Adulto , Cicatriz/diagnóstico , Cicatriz/etiología , Terapia Combinada/efectos adversos , Terapia Combinada/métodos , Relación Dosis-Respuesta a Droga , Punción Seca/efectos adversos , Punción Seca/instrumentación , Femenino , Estudios de Seguimiento , Humanos , Terapia por Láser/efectos adversos , Láseres de Gas/uso terapéutico , Masculino , Agujas/efectos adversos , Ondas de Radio/efectos adversos , Terapia por Radiofrecuencia/instrumentación , Terapia por Radiofrecuencia/métodos , Estudios Retrospectivos , Índice de Severidad de la Enfermedad , Resultado del Tratamiento , Adulto JovenRESUMEN
BACKGROUND: Laser and energy-based devices may be used for many cutaneous indications, including facial resurfacing, improving skin conditions, and reducing signs of photoaging. Currently, no consensus papers or guidelines exist concerning peri-operative agents and specifically their use for laser skin resurfacing and their potential/possible role in prevention or treatment of side effects. AIM: To explore current practice using laser and energy devices, a survey was developed to identify the trends in pre- and postprocedural treatment measures. METHODS: The survey was sent out digitally to 300 randomly selected US dermatologist and plastic surgeon physicians practicing medical esthetics using laser and other energy devices treatment for facial rejuvenation. The survey gathered information on demographics, types of devices used in the clinic and pre-/postprocedural measures for facial laser, and other energy-based devices treatment. RESULTS: The survey was active from June 15, to July 15, 2018, and fifty-eight dermatologists and plastic surgeons completed the survey (19.3% response rate, 58/300). The results showed inconsistency in skin preparation strategies and postprocedure wound care. The majority of survey participants (55/58 [96%]) reported prophylactic oral antiviral use pre- and post-treatment; however, there was inconsistency about when to start and when to stop the use. A similar inconsistency existed in the recommended period of post-treatment sun protection before and after treatment. CONCLUSION: The results of the survey confirmed the lack of consistency in the types and duration of pre- and postprocedural measures-emphasizing the need for evidence-based recommendations to optimize outcomes, prevent infection, enhance comfort, and reduce downtime.
Asunto(s)
Terapia por Luz de Baja Intensidad/efectos adversos , Regeneración de la Piel con Plasma/efectos adversos , Cuidados Posoperatorios/estadística & datos numéricos , Complicaciones Posoperatorias/terapia , Cuidados Preoperatorios/estadística & datos numéricos , Terapia por Radiofrecuencia/efectos adversos , Consenso , Dermatólogos/estadística & datos numéricos , Cara , Humanos , Terapia por Luz de Baja Intensidad/normas , Terapia por Luz de Baja Intensidad/estadística & datos numéricos , Regeneración de la Piel con Plasma/normas , Regeneración de la Piel con Plasma/estadística & datos numéricos , Cuidados Posoperatorios/métodos , Cuidados Posoperatorios/normas , Complicaciones Posoperatorias/etiología , Guías de Práctica Clínica como Asunto , Cuidados Preoperatorios/métodos , Cuidados Preoperatorios/normas , Terapia por Radiofrecuencia/normas , Terapia por Radiofrecuencia/estadística & datos numéricos , Rejuvenecimiento , Piel/inmunología , Piel/efectos de la radiación , Envejecimiento de la Piel/fisiología , Envejecimiento de la Piel/efectos de la radiación , Cirujanos/estadística & datos numéricos , Encuestas y Cuestionarios/estadística & datos numéricos , Resultado del Tratamiento , Cicatrización de HeridasRESUMEN
BACKGROUND: There is a tremendous demand for dermal rejuvenation with minimal invasiveness and patient downtime. AIMS: In this study, we evaluated the performance of nonfractional monopolar radiofrequency for the improvement of photoaged skin texture and wrinkles. METHODS: In total, 32 6-week-old female hairless mice were randomized into four groups of eight mice each: (a) healthy control, (b) UVB-exposed, (c) UVB + microneedling, and (d) UVB + microneedle RF. After applying each treatment modality, skin surface was globally investigated and histologically evaluated senile skin change. Immunohistochemistry was tested with the primary antibody to collagen type I and III. RESULTS: After UVB exposure, the Ra value was significantly increased, leading to clinical development of wrinkles with xerotic scales. Depth and number of wrinkles showed gradual improvement in RF-treated mice. The mean Ra value of the RF-treated group decreased significantly. The RF-treated group showed decreased epidermal thickness, suppression of dermal inflammatory cell infiltration, and increased density of collagen fibers and amount of elastic fibers. CONCLUSIONS: Microneedle RF treatment alleviates photoaged skin texture and wrinkles in this mouse model. To the best of our knowledge, our results provide the first evidence that a nonfractional monopolar microneedle radiofrequency device may contribute to the treatment of UV-damaged skin.
Asunto(s)
Técnicas Cosméticas/efectos adversos , Punción Seca/métodos , Terapia por Radiofrecuencia/métodos , Envejecimiento de la Piel/efectos de la radiación , Piel/patología , Animales , Modelos Animales de Enfermedad , Punción Seca/efectos adversos , Punción Seca/instrumentación , Epidermis/patología , Epidermis/efectos de la radiación , Femenino , Humanos , Ratones , Ratones Pelados , Agujas/efectos adversos , Terapia por Radiofrecuencia/efectos adversos , Terapia por Radiofrecuencia/instrumentación , Rejuvenecimiento , Piel/efectos de la radiación , Envejecimiento de la Piel/patología , Rayos Ultravioleta/efectos adversosRESUMEN
BACKGROUND: Acne scars lead to social and psychological problems for patients, and they should be treated effectively. Ablative and nonablative lasers have been used for the treatment of acne scars in recent years. AIMS: The aim of this study was to evaluate the effectivity of combined FCL and FmRF treatment for acne scars retrospectively. METHODS: A total of 72 patients with acne scars who received FCL + FmRF treatment between 2014 and 2016 were included in this study. Photographs of patients before treatment and 1 month following the last treatment session were scored by two blinded researchers, according to the ECCA acne scar scoring method. Patients were contacted via telephone after 1 month following the last treatment and asked to evaluate their satisfaction with the treatment outcome using a 5-point Likert-type scale. RESULTS: A significant decrease was noted in ECCA scores after the treatment along with temporary side effects. Change from pretreatment scores was significantly higher in patients very satisfied vs satisfied with treatment. The number of treatment sessions was positively correlated with treatment-related change in ECCA scores. CONCLUSIONS: In conclusion, our findings revealed association of FCL + FmRF treatment with significantly improved ECCA scores, mild pain experience, and low rate of side effects in patients with acne scars, despite usage of high-energy FLC dose and five sessions of treatment on average. More remarkable improvement in ECCA scores during treatment seems to be associated with higher patient satisfaction and to be more likely in patients with darker skin types.
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Acné Vulgar/complicaciones , Cicatriz/terapia , Láseres de Gas/uso terapéutico , Terapia por Luz de Baja Intensidad/métodos , Terapia por Radiofrecuencia/métodos , Adulto , Cicatriz/etiología , Terapia Combinada/efectos adversos , Terapia Combinada/métodos , Femenino , Humanos , Terapia por Luz de Baja Intensidad/efectos adversos , Terapia por Luz de Baja Intensidad/instrumentación , Masculino , Agujas/efectos adversos , Dimensión del Dolor , Dolor Asociado a Procedimientos Médicos/diagnóstico , Dolor Asociado a Procedimientos Médicos/etiología , Satisfacción del Paciente , Terapia por Radiofrecuencia/efectos adversos , Terapia por Radiofrecuencia/instrumentación , Estudios Retrospectivos , Resultado del Tratamiento , Adulto JovenRESUMEN
BACKGROUND: While a considerable number of cases with papulopustular rosacea (PPR) are resistant to conventional medications, therapeutic regimens are not currently established. Pulsed dye laser (PDL) and fractional microneedling radiofrequency (FMR) have previously demonstrated satisfactory results for anti-angiogenesis, anti-inflammation, and dermal remodeling. AIMS: To evaluate the efficacy and safety of novel combination regimen with low-dose oral isotretinoin, PDL, and FMR in the treatment of recalcitrant PPR. PATIENTS AND METHODS: A retrospective study was undertaken for recalcitrant PPR patients to evaluate the clinical course of novel combination regimen. Twenty-five PPR patients who had failed in previous first-line therapies were enrolled. They were treated with three sessions of PDL and FMR consecutively at 4-week intervals, maintaining daily oral administration of 10 mg isotretinoin for 8 weeks. Objective assessments, erythema index measurement, and patients' subjective satisfaction were evaluated at each visit and 16 weeks after the final treatment. RESULTS: At the final follow-up visit, the number of papules and pustules decreased by 71%, and erythema index by 54% compared with baseline (P < 0.05 for both). Physician's global assessment based on rosacea severity score and patients' subjective assessments paralleled with these results. No serious side effect was observed during whole study periods. CONCLUSION: This novel combination regimen demonstrated satisfactory efficacy with reasonable safety profiles for the treatment of recalcitrant PPR.
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Isotretinoína/administración & dosificación , Láseres de Colorantes/uso terapéutico , Terapia por Luz de Baja Intensidad/instrumentación , Terapia por Radiofrecuencia/instrumentación , Rosácea/terapia , Administración Oral , Adulto , Terapia Combinada/efectos adversos , Terapia Combinada/instrumentación , Terapia Combinada/métodos , Relación Dosis-Respuesta a Droga , Femenino , Estudios de Seguimiento , Humanos , Isotretinoína/efectos adversos , Láseres de Colorantes/efectos adversos , Terapia por Luz de Baja Intensidad/efectos adversos , Masculino , Persona de Mediana Edad , Agujas/efectos adversos , Satisfacción del Paciente , Terapia por Radiofrecuencia/efectos adversos , Estudios Retrospectivos , Rosácea/diagnóstico , Índice de Severidad de la Enfermedad , Resultado del TratamientoRESUMEN
The past decade has experienced a surge in the frequency of nonsurgical procedures, including injectables, skin rejuvenation, and nonsurgical fat reduction. Nonsurgical fat reduction methods include cryolipolysis (Coolsculpting), ultrasound (Vaser Shape), laser (Liposonix), and radiofrequency (Vanquish). These methods generally produce good results, with cryolipolysis gaining much popularity over the past few years. Multiple reports of paradoxical adipose hyperplasia have been reported with Coolsculpting, with an incidence of 0.025% to 1%. This entity has never been reported with other methods of nonsurgical fat reduction, including noninvasive radiofrequency (Vanquish). We present a case of paradoxical adipose hyperplasia in a 57-year-old male following treatment with noninvasive radiofrequency (Vanquish) to the abdomen. He was treated with power-assisted liposuction to the abdomen and flanks. This is the first case in the literature of paradoxical adipose hyperplasia in a patient treated with this form of noninvasive fat reduction.
Asunto(s)
Contorneado Corporal/efectos adversos , Lipectomía , Terapia por Radiofrecuencia/efectos adversos , Grasa Subcutánea Abdominal/patología , Contorneado Corporal/métodos , Criocirugía/efectos adversos , Tratamiento con Ondas de Choque Extracorpóreas/efectos adversos , Humanos , Hiperplasia/etiología , Hiperplasia/terapia , Terapia por Luz de Baja Intensidad/efectos adversos , Masculino , Persona de Mediana Edad , Grasa Subcutánea Abdominal/efectos de la radiación , Resultado del TratamientoRESUMEN
BACKGROUND: Acne scarring occurs at a young age and causes distress for many patients. Various treatment modalities have been tried. OBJECTIVE: This study investigated the efficacy of combination therapy with topical poly-lactic acid and microneedle fractional radiofrequency (MFRF) for acne scars. MATERIALS AND METHODS: Patients with acne scars on both the cheeks were included. Poly-lactic acid was applied to the acne scars on one side of the face before MFRF treatment. The other side of the face was treated with MFRF and normal saline. Patients received 3 treatment sessions and were evaluated based on visual assessment and patient satisfaction. After the last treatment, objective scar assessment of scar smoothness, size, brightness, and overall improvement was performed. RESULTS: Both acne scar assessment scores and patient satisfaction were better with combination therapy (p = .036 and p = .009, respectively) than with monotherapy. Combination therapy resulted in significantly better efficacy for scar smoothness (p < .001), scar size (p = .003), and overall improvement (p < .001), but not for brightness (p = .151). CONCLUSION: Combination therapy resulted in significantly better clinical outcomes, including better scar smoothness and smaller scar size. Therefore, we believe this combination therapy is a safe and effective treatment for acne scars.
Asunto(s)
Acné Vulgar/complicaciones , Cicatriz/terapia , Rellenos Dérmicos/administración & dosificación , Punción Seca/métodos , Poliésteres/administración & dosificación , Terapia por Radiofrecuencia/métodos , Administración Cutánea , Adulto , Cicatriz/diagnóstico , Cicatriz/etiología , Terapia Combinada/efectos adversos , Terapia Combinada/instrumentación , Terapia Combinada/métodos , Punción Seca/efectos adversos , Punción Seca/instrumentación , Femenino , Humanos , Masculino , Persona de Mediana Edad , Agujas/efectos adversos , Satisfacción del Paciente , Terapia por Radiofrecuencia/efectos adversos , Terapia por Radiofrecuencia/instrumentación , Índice de Severidad de la Enfermedad , Resultado del Tratamiento , Adulto JovenAsunto(s)
Técnicas Cosméticas/efectos adversos , Punción Seca/efectos adversos , Parestesia/etiología , Terapia por Radiofrecuencia/efectos adversos , Plexo Cervical/lesiones , Plexo Cervical/efectos de la radiación , Terapia Combinada/efectos adversos , Terapia Combinada/métodos , Técnicas Cosméticas/instrumentación , Punción Seca/instrumentación , Punción Seca/métodos , Femenino , Humanos , Persona de Mediana Edad , Agujas/efectos adversos , Parestesia/diagnóstico , Ondas de Radio/efectos adversos , Terapia por Radiofrecuencia/instrumentación , Terapia por Radiofrecuencia/métodos , Envejecimiento de la PielRESUMEN
BACKGROUND: Osteomyelitis was determined in two patients following radiofrequency turbinoplasty. This is a rare complication of the procedure, and we have found no other case reports concerning osteomyelitis as a specific complication of radiofrequency turbinoplasty. CASE PRESENTATION: Two patients underwent radiofrequency turbinoplasty. Postoperatively they presented with clinical features such as a faecal smell in the nose, crusting and local necrosis of the inferior turbinates, which led to the clinical and histological diagnosis of osteomyelitis. The infections were polymicrobial, as verified by bacterial growth in the nasal biopsies. They were treated with surgical debridement, local and systemic antibiotics and nasal saline irrigation. INTERPRETATION: The patients underwent surgery that involved the use of more insertion channels than recommended by the distributor of the surgical equipment, and local anaesthesia included adrenaline. These two factors may well have caused or increased the likelihood of developing osteomyelitis. One patient has an open nose giving rise to no concern after treatment; the other patient has developed empty nose syndrome on the right side. We report these cases in order to raise and aid awareness regarding this possible complication of radiofrequency turbinoplasty.
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Osteomielitis/etiología , Terapia por Radiofrecuencia , Rinoplastia , Cornetes Nasales/cirugía , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Osteomielitis/tratamiento farmacológico , Osteomielitis/microbiología , Osteomielitis/cirugía , Complicaciones Posoperatorias/tratamiento farmacológico , Complicaciones Posoperatorias/etiología , Complicaciones Posoperatorias/microbiología , Complicaciones Posoperatorias/cirugía , Terapia por Radiofrecuencia/efectos adversos , Terapia por Radiofrecuencia/métodos , Rinoplastia/efectos adversos , Rinoplastia/métodosRESUMEN
The present gold standard of the treatment of cutaneous leishmaniasis (CL) is pentavalent antimonials either sodium stibogluconate (Pentostam) or meglumine antimoniate (Glucantime), These drugs are quite toxic. They are given by injection and usually administered intramuscularly or intravenously for three weeks or intralesionally for seven or more weeks. That is why the successful introduction of radiofrequency-induced heat therapy using a Thermomed™ 1.8 instrument administered in a single application, with minimal toxic effects, is so important for the treatment of CL.
Asunto(s)
Calor/uso terapéutico , Leishmaniasis Cutánea/terapia , Terapia por Radiofrecuencia/métodos , Adolescente , Adulto , Anciano , Animales , Antiprotozoarios/uso terapéutico , Niño , Preescolar , Citocinas/biosíntesis , Femenino , Humanos , Inyecciones Intramusculares/efectos adversos , Masculino , Antimoniato de Meglumina/efectos adversos , Antimoniato de Meglumina/uso terapéutico , Antimoniato de Meglumina/toxicidad , Persona de Mediana Edad , Pentostatina/efectos adversos , Pentostatina/uso terapéutico , Pentostatina/toxicidad , Terapia por Radiofrecuencia/efectos adversos , Terapia por Radiofrecuencia/instrumentación , Adulto JovenRESUMEN
BACKGROUND: Convective radiofrequency water vapor thermal therapy with the Rezum system is a relatively new treatment for benign prostatic hyperplasia (BPH). We present results from a single surgeon in an office setting. METHODS: A retrospective review of 129 patients from a single surgeon who underwent the Rezum procedure was performed. All patients were at least 4 months out from treatment. International prostate symptom scores (IPSS), maximum flow rates (Qmax), residual urine volumes, medication usage, and adverse events were monitored. Data were analyzed at baseline, 15-45 days, 46-90 days, and 91-180 days after treatment. A scripted patient questionnaire was attempted over the phone to all patients. It was administered by a resident and medical student who do not work in the provider's office. RESULTS: Maximal effects were noted at the 91-180 day interval. IPSS improved from a baseline of 18.3 to 6.9 and Qmax from 10.5 to 16.8 mL/s. Improvements were independent of starting symptom score, median lobe treatment, and prostate size. There was a 17% prostate volume reduction based on TRUS and 14% based on PSA. The most common adverse events were urinary tract infections (17%) and transient urinary retention (14%). In total 90% of patients were able to come off their BPH medications and 86% of patients would recommend the procedure to a friend. CONCLUSIONS: Rezum radiofrequency water vapor thermal therapy offers a minimally invasive option for BPH management with moderate improvement in symptoms and flow rate. The results appear to be independent of prostate size or presence of a median lobe, and have now been replicated in a single office setting.