[The normalizing effect of air ions on neuroticized rats with different typological behavioral characteristics]. / Normalizuiushchee vliianie aéroionov na nevrotizirovannykh krys s raznymi tipologicheskimi osobennostiami povedeniia.

The work was carried out in 98 white male rats weighting 200-250 g. Typological properties of behaviour were estimated by locomotor activity in the open field. Neurosis was induced by electro-pain irritation (15 min daily during 3 weeks), accompanied by the white noise (4 h daily). The rats were influenced by air ions generated by Chizhevsky air ionizer ("Elion-132") for 2 h daily during the period of neurotization. It was shown that the degree of some pathological changes in neurosis depended on typological properties of rats. Air ions were established to prevent completely development of physiological changes typical for the model of experimental neuroses, i.e., increase of arterial pressure, Hildebrandt index and gastric ulcer formation. Air ions significantly decreased the number of gastric mucous membrane erosions. Air ions normalized activity of respiratory enzymes (succinate dehydrogenase and NADH-dehydrogenase) in rat brain cells and activated their exploratory behaviour.

[Alteration of Ca2+, Mg2+-ATPase activity from rat hypothalamus and myocardium in development of the neurotic state]. / Izmeneniia aktivnosti Ca, Mg-zavisimoi ATf-azy v gipotalamuse i miokarde pri formirovanii nevroticheskogo sostoianiia u krys.

Simultaneous decrease of Ca2+, Mg2+-ATPase activity occurred in rat hypothalamus and myocardium during experimental neurosis. The decrease of the enzymatic activity was more distinct in hypothalamus than in myocardium. In hypothalamus the decreased enzymatic activity maintained within a week after completion of the excitation of the animals.

[Subcellular changes in the cortex of the motor analyzer and hippocampus of dogs with locally manifested neuroses]. / Subkletochnye izmeneniia v kore dvigatel'nogo analizatora i gippokampa sobak pri nevroze s lokal'nym proiavleniem.

In experiments on dogs with local neurosis-continuous flexion of the foreleg-changes were revealed in the beta-rhythm amplitude and the frequency of mean unit activity in the motor cortex, and the appearance and increased amplitude of the theta-rhythm in the hippocampus. Specific activity of Na+-K+-activated, and Mg2+-dependent ATPase decreases in subcortical fractions of the experimental animals' cerebral cortex by 55.0% in the synaptic membranes and 2 to 2.5 times in light and heavy synaptosomes, respectively. In similar fractions of the dorsal hippocampus, the activity of the enzyme decreases by 30.0% in the synaptic membranes and increases by 16.6% in the light synaptosomes and by 6.6% in the heavy ones.

[Transport ATP-ase activities in different brain structures during development of experimental neuroses in rats]. / Aktivnost' transportnykh ATF-az v razlichnykh mozgovykh obrazovaniiakh pri formirovanii éksperimental'nogo nevroza u krys.

Typical alterations in activity of transport ATPases were observed in crude mitochondrial fractions isolated from various rat brain parts after chronic stressor effects. In the acute period of stress reaction activity of Na+, K+-ATPase was increased in synaptosomes of frontal cortex, hypothalamus and hippocamp. The enzymatic activity normalized after chronic action of the stressor agents. But under these conditions the activity of Mg2+-ATPase was distinctly decreased in cortex, hypothalamus and in pons Varolii.