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1.
Langenbecks Arch Surg ; 409(1): 17, 2023 Dec 26.
Artículo en Inglés | MEDLINE | ID: mdl-38147122

RESUMEN

OBJECTIVE: To compare the effects of ampulla-guided realignment and conventional gallbladder triangle anatomy in difficult laparoscopic cholecystectomy (DLC). METHODS: From June 2021 to August 2022, data from 100 patients undergoing DLC at Nanjing Hospital of Traditional Chinese Medicine were analyzed retrospectively. Patients were divided into two groups: the experimental group (LC with the ampulla-guided realignment) and the control group (conventional LC with triangular gallbladder anatomy), with 50 patients per group. The intraoperative blood loss, operation time, postoperative drainage tube indwelling time, hospitalization time, bile duct injury rate, operation conversion rate, and incidence of postoperative complications were recorded and compared between the two groups. The pain response and daily activities of the patients in the two groups were evaluated 48 h after the operation. RESULTS: The amount of intraoperative blood loss, postoperative drainage tube indwelling time, hospital stay, operation conversion rate, pain degree at 24 and 48 h after operation, bile duct injury incidence, and total postoperative complication rate were shorter or lower in the experimental group than those in the control group (p < 0.05). The Barthel index scores of both groups were higher 48 h after the operation than before the operation, and the experimental group was higher than the control group (p < 0.05). CONCLUSION: The ampulla-guided alignment in DLC surgery was more beneficial in promoting postoperative recovery, reducing postoperative pain response, reducing the incidence of postoperative complications, and reducing bile duct injury.


Asunto(s)
Traumatismos Abdominales , Colecistectomía Laparoscópica , Vesícula Biliar , Humanos , Pérdida de Sangre Quirúrgica , Colecistectomía Laparoscópica/efectos adversos , Vesícula Biliar/cirugía , Dolor Postoperatorio/epidemiología , Complicaciones Posoperatorias/epidemiología , Estudios Retrospectivos
2.
J Vis Exp ; (201)2023 Nov 10.
Artículo en Inglés | MEDLINE | ID: mdl-38009746

RESUMEN

Acute gastrointestinal injury (AGI) is a significant factor contributing to increased mortality in patients receiving intensive care unit (ICU) care. Traditional Chinese medicine's acupuncture techniques offer an alternative approach to treating digestive disorders by controlling gastrointestinal secretion, improving gastrointestinal motility, and minimizing side effects. Transabdominal intestinal ultrasonography has proven effective in assessing gastrointestinal injury in critically ill patients. This study aims to evaluate the therapeutic effect of acupuncture in AGI patients using ultrasound. The main steps of the study include the syndrome-based selection of appropriate acupuncture points, including Hegu (LI4), Zhongwan (CV 12), Tianshu (ST 25), Zusanli (ST 36), Shangjuxu (ST 37), and Xiajuxu (ST 39), followed by a 30 min Deqi acupuncture session once a day for 1 week. The treatment's effectiveness is assessed by an experienced physician using abdominal gastrointestinal ultrasonography. This article provides a detailed account of how to standardize the use of acupuncture in treating gastrointestinal dysfunction in critically ill patients.


Asunto(s)
Traumatismos Abdominales , Terapia por Acupuntura , Humanos , Enfermedad Crítica , Tracto Gastrointestinal/diagnóstico por imagen , Abdomen , Puntos de Acupuntura
3.
J Trauma Acute Care Surg ; 95(1): 55-61, 2023 07 01.
Artículo en Inglés | MEDLINE | ID: mdl-36872522

RESUMEN

INTRODUCTION: Injuries to the liver and small bowel are common in multiple injuries. While there are currently a variety of accepted damage-control techniques to expeditiously manage such injuries, morbidity and mortality remain high. Pectin polymers have previously been shown to effectively seal visceral organ injuries ex vivo through physiochemical entanglement with the glycocalyx. We sought to compare the standard of care for the management of penetrating liver and small bowel injuries with a pectin-based bioadhesive patch in a live animal model. METHODS: Fifteen adult male swine underwent a laparotomy with standardized laceration to the liver. Animals were randomized to one of three treatment arms: packing with laparotomy pads (n = 5), suture repair (n = 5), or pectin patch repair (n = 5). Following 2 hours of observation, fluid was evacuated from the abdominal cavity and weighed. Next, a full-thickness small bowel injury was created, and animals were randomized to either a sutured repair (n = 7) or pectin patch repair (n = 8). The segment of bowel was then pressurized with saline, and the burst pressure was recorded. RESULTS: All animals survived the protocol to completion. There were no clinically significant differences between groups regarding baseline vitals or laboratory studies. On one-way analysis of variance, there was a statistically significant difference between groups regarding blood loss after liver repair (26 mL suture vs. 33 mL pectin vs. 142 mL packing, p < 0.01). On post hoc analysis, there was no statistically significant difference between suture and pectin ( p = 0.9). After repair, small bowel burst pressures were similar between pectin and suture repair (234 vs. 224 mm Hg, p = 0.7). CONCLUSION: Pectin-based bioadhesive patches performed similarly to the standard of care for the management of liver lacerations and full-thickness bowel injuries. Further testing is warranted to assess the biodurability of a pectin patch repair, as it may offer a simple option to effectively temporize traumatic intra-abdominal injuries.


Asunto(s)
Cavidad Abdominal , Traumatismos Abdominales , Traumatismo Múltiple , Animales , Masculino , Traumatismos Abdominales/cirugía , Intestino Delgado/cirugía , Intestino Delgado/lesiones , Traumatismo Múltiple/terapia , Pectinas , Porcinos
4.
Dis Markers ; 2022: 2970257, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-36193496

RESUMEN

Objective: To assess the treatment efficacy of laparoscopic totally extraperitoneal repair for inguinal hernia. Methods: Between November 2018 and May 2020, 130 patients with inguinal hernias diagnosed and treated in our hospital were randomly recruited and assigned to receive either tension-free hernia repair (control group) or laparoscopic totally extraperitoneal repair (study group) at the random method. All patients received routine care including external traditional Chinese medicine (TCM) application. Outcome measures included surgical indices, numeric rating scale (NRS) scores, infections, and postoperative complications. Results: Laparoscopic surgery is associated with a shorter operation duration, time-lapse before postoperative off-bed activity, and hospital stay, as well as less intraoperative hemorrhage volume compared to tension-free hernia repair in the control group. Patients in the study group had considerably lower NRS ratings after therapy than those in the control group. (P < 0.05). After treatment, the levels of blood cell count (WBC), C-reactive protein (CRP), and procalcitonin (PCT) in the study group were lower than those in the control group (P < 0.05). In the control group, there were 0 cases of hematoma, 3 cases of subcutaneous effusion, 4 cases of urinary retention, 5 cases of scrotal effusion, and 1 case of bladder injury. In the study group, there were 0 cases of hematoma, 1 case of subcutaneous fluid, 1 case of urinary retention, 0 cases of scrotal fluid, and 0 cases of bladder injury. Laparoscopic surgery resulted in a lower incidence of postoperative complications versus traditional surgery (P <0.05). Conclusion: Laparoscopic totally extraperitoneal repair for inguinal hernia improves the intraoperative indices, mitigates postoperative pain, and reduces the risks of infections and complications, with the advantages of short operation duration, less hemorrhage volume, and shorter hospital stay. It shows great potential for clinical promotion.


Asunto(s)
Traumatismos Abdominales , Hernia Inguinal , Laparoscopía , Retención Urinaria , Traumatismos Abdominales/cirugía , Proteína C-Reactiva , Hematoma/cirugía , Hernia Inguinal/cirugía , Humanos , Laparoscopía/métodos , Complicaciones Posoperatorias , Polipéptido alfa Relacionado con Calcitonina , Estudios Retrospectivos , Resultado del Tratamiento , Retención Urinaria/cirugía
5.
Emerg Radiol ; 29(5): 895-901, 2022 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-35829928

RESUMEN

PURPOSE: There are limited data comparing the severity of traumatic adrenal injury (TAI) and the need for interventions, such as transfusions, hospitalization, or incidence of adrenal insufficiency (AI) and other clinical outcomes. The aim of this study was to analyze the relationship between the grade of TAI and the need for subsequent intervention and clinical outcomes following the injury. METHODS: After obtaining Institutional Review Board approval, our trauma registry was queried for patients with TAI between 2009 and 2017. Contrast-enhanced computed tomography (CT) examinations of the abdomen and pelvis were evaluated by a board-certified radiologist with subspecialty expertise in abdominal and trauma imaging, and adrenal injuries were classified as either low grade (American Association for the Surgery of Trauma (AAST) grade I-III) or high grade (AAST grade IV-V). Patients without initial contrast-enhanced CT imaging and those with indeterminate imaging findings on initial CT were excluded. RESULTS: A total of 129 patients with 149 TAI were included. Eight-six patients demonstrated low-grade injuries and 43 high grade. Age, gender, and Injury Severity Score (ISS) were not statistically different between the groups. There was an increased number of major vascular injuries in the low-grade vs. high-grade group (23% vs. 5%, p < 0.01). No patient required transfusions or laparotomy for control of adrenal hemorrhage. There was no statistical difference in hospital length of stay (LOS), ventilator days, or mortality. Low-grade adrenal injuries were, however, associated with shorter ICU LOS (10 days vs. 16 days, p = 0.03). CONCLUSION: The need for interventions and clinical outcomes between the low-grade and high-grade groups was similar. These results suggest that, regardless of the TAI grade, treatment should be based on a holistic clinical assessment and less focused on specific interventions directed at addressing the adrenal injury.


Asunto(s)
Traumatismos Abdominales , Heridas no Penetrantes , Traumatismos Abdominales/diagnóstico por imagen , Traumatismos Abdominales/terapia , Humanos , Puntaje de Gravedad del Traumatismo , Tiempo de Internación , Estudios Retrospectivos , Heridas no Penetrantes/diagnóstico por imagen , Heridas no Penetrantes/terapia
7.
Med Sci Sports Exerc ; 54(2): 206-210, 2022 02 01.
Artículo en Inglés | MEDLINE | ID: mdl-34559722

RESUMEN

INTRODUCTION: Core muscle injuries (CMI) are common in every sport. To minimize lost playing time, providers apply various nonsurgical treatments, including platelet-rich plasma, corticosteroids, ultrasound (US)-guided percutaneous tenotomy, and prolotherapy. Limited data exist with regard to their effectiveness. We chose to review a cohort of consecutive professional and collegiate athletes who sustained CMI at various points within their seasons and underwent a combination of US-guided percutaneous needle "tenotomy" and corticosteroid injections to complete the remainder of their seasons. METHODS: Twenty-five consecutive collegiate or professional athletes with CMI involving the rectus abdominis-adductor aponeurotic plate were included in this retrospective study. Athletes with concomitant symptomatic hip femoroacetabular impingement were included in the study. The primary outcome measure was whether athletes completed their seasons. Secondary measures were weeks played after the procedures (delay until surgery), need for repeat procedures, and outcomes after eventual surgery. Postoperative performance was assessed via interviews at 6 wk and 6 months postoperatively. RESULTS: Twenty-one of 25 (84%) athletes completed their seasons. On average, athletes returned to play 3 d (range, 1-9 d) after the procedures. Surgical repair was delayed a mean of 18 wk (range, 2-44 wk). Seven athletes had concomitant symptomatic femoroacetabular impingement and six underwent combined hip arthroscopy and core muscle repairs. Among 17 patients who eventually had core muscle surgery alone (no hip surgery), 82% (14 of 17) reported performing at their preinjury level at 6 wk. At 6 months, 96% of postop athletes (22 of 23) reported performing at their preinjury level. CONCLUSIONS: Temporizing CMI with US-guided percutaneous tenotomy and corticosteroid injections is effective in allowing continued sport participation among high-level athletes and does not negatively affect postoperative outcomes.


Asunto(s)
Traumatismos Abdominales/terapia , Corticoesteroides/administración & dosificación , Antiinflamatorios/administración & dosificación , Traumatismos en Atletas/terapia , Recto del Abdomen/lesiones , Tenotomía/métodos , Ultrasonografía Intervencional/métodos , Traumatismos Abdominales/diagnóstico por imagen , Corticoesteroides/uso terapéutico , Adulto , Antiinflamatorios/uso terapéutico , Traumatismos en Atletas/diagnóstico por imagen , Rendimiento Atlético , Terapia Combinada , Femenino , Estudios de Seguimiento , Humanos , Inyecciones Intramusculares , Masculino , Estudios Retrospectivos , Volver al Deporte , Tiempo de Tratamiento , Resultado del Tratamiento , Adulto Joven
8.
Am J Surg ; 223(5): 988-992, 2022 05.
Artículo en Inglés | MEDLINE | ID: mdl-34657721

RESUMEN

BACKGROUND: Autotransfusion (AT) in trauma laparotomy is limited by concern that enteric contamination (EC) increases complications, including infections. Our goal was to determine if AT use increases complications in trauma patients undergoing laparotomy with EC. METHODS: Trauma patients undergoing laparotomy from October 2011-November 2020 were reviewed. Patients were excluded if they did not receive blood in the operating room, did not have a full thickness hollow viscus injury, or died <24 h from admission. AT and non-AT patients were matched. Outcomes were compared. RESULTS: 185 patients were included, 60 received AT, and 46 pairs were matched. After matching, demographics were similar. No differences were noted in septic complications (33 vs 41%, p = 0.39), overall complications (59% vs 54%, p = 0.67), or mortality (13 vs 6%, p = 0.29). CONCLUSIONS: AT use in contaminated trauma laparotomy fields was not associated with a higher rate of complications.


Asunto(s)
Traumatismos Abdominales , Laparotomía , Traumatismos Abdominales/complicaciones , Traumatismos Abdominales/cirugía , Transfusión de Sangre Autóloga , Humanos , Laparotomía/efectos adversos , Estudios Retrospectivos , Vísceras
9.
Med Sci Monit ; 26: e921039, 2020 May 12.
Artículo en Inglés | MEDLINE | ID: mdl-32394977

RESUMEN

BACKGROUND At certain frequencies, abdominal naprapathy effectively alleviates functional dyspepsia with spleen deficiency. The present study explored the effects of various frequencies of abdominal naprapathy on gastrointestinal mucosal cells in spleen-deficient rabbits. MATERIAL AND METHODS The model of spleen deficiency was established by the method of bitter cold and catharsis. The rabbits were treated with various frequencies (50 - 100 and 201 - 250 vibrations/min) of abdominal naprapathy.  RESULTS In model rabbits, gastrointestinal mucosal thickness was changed, mucosal epithelial cells were necrotic significantly, a large number of inflammatory cells were infiltrated, and duodenal villus were destroyed. The gastrointestinal mucosal cells had different degrees of regeneration and remodeling under various frequencies of abdominal naprapathy intervention. Among them, the abdominal naprapathy with manipulation frequency of 101 - 150 times/min showed the best effect. CONCLUSIONS The abdominal naprapathy, especially with frequency of 101~150 times/min, repairs gastrointestinal mucosal injury of spleen-deficiency rabbits.


Asunto(s)
Traumatismos Abdominales/terapia , Tracto Gastrointestinal/fisiopatología , Medicina Tradicional China/métodos , Abdomen/patología , Animales , China , Modelos Animales de Enfermedad , Duodeno/metabolismo , Dispepsia/terapia , Femenino , Mucosa Intestinal/metabolismo , Masculino , Conejos , Bazo , Stents/tendencias
10.
PLoS One ; 15(3): e0229898, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32142529

RESUMEN

OBJECTIVES: To test the feasibility of a randomized controlled study design comparing epidural analgesia (EDA) with continuous wound infiltration (CWI) in respect to postoperative complications and mobility to design a future multicentre randomized controlled trial. DESIGN, SETTING, PARTICIPANTS: CWI has been developed to address drawbacks of EDA. Previous studies have established the equivalent analgesic potential of CWI compared to EDA. This is a single centre, non-blinded pilot randomized controlled trial at a tertiary surgical centre. Patients undergoing elective non-colorectal surgery via a midline laparotomy were randomized to EDA or CWI. Endpoints included recruitment, feasibility of assessing postoperative mobility with a pedometer and morbidity. No primary endpoint was defined and all analyses were explorative. INTERVENTIONS: CWI with local anaesthetics (experimental group) vs. thoracic EDA (control). RESULTS: Of 846 patients screened within 14 months, 71 were randomized and 62 (31 per group) included in the intention-to-treat analysis. Mobility was assessed in 44 of 62 patients and revealed no differences within the first 3 postoperative days. Overall morbidity did not differ between the two groups (measured via the comprehensive complication index). Median pain scores at rest were comparable between the two groups, while EDA was superior in pain treatment during movement on the first, but not on the second and third postoperative day. Duration of preoperative induction of anaesthesia was shorter with CWI than with EDA. Of 17 serious adverse events, 3 were potentially related to EDA, while none was related to CWI. CONCLUSION: This trial confirmed the feasibility of a randomized trial design to compare CWI and EDA regarding morbidity. Improvements in the education and training of team members are necessary to improve recruitment. TRIAL REGISTRATION: DRKS00008023.


Asunto(s)
Traumatismos Abdominales/cirugía , Analgesia Epidural/métodos , Anestesia Local/métodos , Anestésicos Locales/administración & dosificación , Traumatismos Abdominales/tratamiento farmacológico , Traumatismos Abdominales/fisiopatología , Analgesia Epidural/efectos adversos , Anestesia Local/efectos adversos , Procedimientos Quirúrgicos Electivos/normas , Femenino , Humanos , Laparotomía/normas , Masculino , Persona de Mediana Edad , Manejo del Dolor/métodos , Dimensión del Dolor/métodos , Dolor Postoperatorio/fisiopatología , Dolor Postoperatorio/prevención & control , Proyectos Piloto , Complicaciones Posoperatorias/fisiopatología , Complicaciones Posoperatorias/prevención & control , Periodo Posoperatorio
11.
Ann Glob Health ; 86(1): 19, 2020 02 25.
Artículo en Inglés | MEDLINE | ID: mdl-32140429

RESUMEN

Background: Perioperative mortality rate (POMR) has been identified as an important measure of access to safe surgical and anesthesia care in global surgery. There has been limited study on this measure in rural Ghana. In order to identify areas for future quality improvement efforts, we aimed to assess the epidemiology of exploratory laparotomy and to investigate POMR as a benchmark quality measure. Methods: Surgical records were reviewed at a regional referral hospital in Eastern Region, Ghana to identify cases of exploratory laparotomy from July 2017 through June 2018. Patient demographics, health information, and outcomes data were collected. Logistic regression was used to identify predictors of perioperative mortality. Findings: The study included operations for 286 adult and 60 pediatric patients. Only 60% of patients were covered by National Health Insurance (NHI). The overall POMR was 11.5% (12.6% adults; 6.7% pediatric). Sixty percent of mortalities were referrals from outside hospitals and the mortality rate for referrals was 13.5%. Odds of mortality was 13 times greater with perforated peptic ulcer disease (OR = 13.1, p = 0.025) and 12 times greater with trauma (OR = 11.7, p = 0.042) when compared to the most common operation. Female sex (OR = 0.3, p = 0.016) and NHI (OR = 0.4, p = 0.031) were protective variables. Individuals 60 years and older (OR = 3.3, p = 0.016) had higher mortality. Conclusion: POMR can be an important outcome and quality indicator for rural populations. Interventions aimed at decreasing emergent hernia repair, preventing perforation of peptic ulcer disease, improving rural infrastructure for response to major trauma, and increasing NHI coverage may improve POMR in rural Ghana.


Asunto(s)
Traumatismos Abdominales/cirugía , Apendicitis/cirugía , Mortalidad Hospitalaria , Obstrucción Intestinal/cirugía , Intususcepción/cirugía , Laparotomía , Úlcera Péptica Perforada/cirugía , Periodo Perioperatorio/mortalidad , Población Rural , Traumatismos Abdominales/epidemiología , Adolescente , Adulto , Apendicitis/epidemiología , Niño , Preescolar , Femenino , Ghana/epidemiología , Humanos , Ileítis/epidemiología , Ileítis/cirugía , Obstrucción Intestinal/epidemiología , Intususcepción/epidemiología , Tiempo de Internación , Modelos Logísticos , Masculino , Persona de Mediana Edad , Programas Nacionales de Salud/estadística & datos numéricos , Readmisión del Paciente , Transferencia de Pacientes/estadística & datos numéricos , Úlcera Péptica Perforada/epidemiología , Factores Protectores , Indicadores de Calidad de la Atención de Salud , Derivación y Consulta/estadística & datos numéricos , Reoperación , Estudios Retrospectivos , Factores de Riesgo , Factores Sexuales , Infección de la Herida Quirúrgica/epidemiología , Fiebre Tifoidea/epidemiología , Fiebre Tifoidea/cirugía , Heridas y Lesiones/epidemiología , Heridas y Lesiones/cirugía
12.
J Wound Care ; 29(2): 94-99, 2020 Feb 02.
Artículo en Inglés | MEDLINE | ID: mdl-32058849

RESUMEN

OBJECTIVE: Children are at high risk of injuries and wounds. The application of medical grade honey is a promising approach to improving the healing of wounds of various origin and severity. However, the use of medical grade honey in young paediatric patients remains limited. The aim of this study is to show the safety, efficacy and usefulness of medical grade honey in abdominal wounds, of different causes, in paediatric patients. METHOD: This was a prospective, observational case series evaluating five young infants with abdominal wounds at the General Hospital in Thessaloniki. All wounds were treated in the same manner with daily medical grade honey applied to the wound area and closely monitored. RESULTS: All treated wounds rapidly presented granulation tissue formation and underwent re-epithelialisation. Peripheral oedema and inflammation decreased upon initial application. Necrotic tissue was effectively debrided when present. Slough was removed and no signs of infection were detected, irrespective of initial wound presentations. Scar formation was minimal and the full range of motion was preserved in all cases. CONCLUSION: Based on this case study, medical grade honey is safe and effective in treating different abdominal wounds, including infected or dehisced wounds as well as burns. The easy application and broad applicability make medical grade honey recommendable as a first-line treatment in paediatric patients.


Asunto(s)
Traumatismos Abdominales/terapia , Apiterapia/métodos , Quemaduras/terapia , Miel , Repitelización , Dehiscencia de la Herida Operatoria/terapia , Infección de la Herida Quirúrgica/terapia , Apendicectomía , Apendicitis/cirugía , Ácido Ascórbico/uso terapéutico , Infecciones por Bacteroides/terapia , Quemaduras Químicas/terapia , Niño , Preescolar , Fármacos Dermatológicos/uso terapéutico , Farmacorresistencia Bacteriana Múltiple , Edema , Femenino , Gastrostomía , Grecia , Humanos , Lactante , Recién Nacido , Inflamación , Infecciones por Klebsiella/terapia , Lanolina/uso terapéutico , Masculino , Neuroblastoma/cirugía , Aceites Volátiles/uso terapéutico , Pomadas , Estudios Prospectivos , Neoplasias Retroperitoneales/cirugía , Vitamina E/uso terapéutico , Vitaminas/uso terapéutico , Óxido de Zinc/uso terapéutico
13.
Asian J Surg ; 42(1): 148-154, 2019 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-30585169

RESUMEN

BACKGROUND/OBJECTIVE: Despite extensive published research, the surgical approach to penetrating abdominal trauma patients is still under debate. Computed tomography-guided tractography (CTT) is an imaging modality in which water soluble iodinated contrast medium is administered into the site of the injury in the CT unit. The aim of this study was to determine the diagnostic accuracy of the CTT. METHODS: A retrospective evaluation was made of patients admitted to the Emergency Department with penetrating abdominal trauma and who underwent CTT. Contrast enhanced abdominal CT and CTT reports, surgical findings and clinical results were examined. RESULTS: Evaluation was made of a total of 101 patients comprising 89 males (88.1%) and 12 females (11.9%). CTT was determined to have 92.8% sensitivity, 93.6% specificity, 97% positive predictive value, and 85.5% negative predictive value. In 27 patients (26.7%) where the CTT indicated passage through the peritoneum, no parenchymal organ injury was present. Only one patient (2.9%) without peritoneal penetration on CTT had organ injury at exploration. No procedure-related morbidities developed. CONCLUSION: CTT is a safe imaging modality for the evaluation of hemodynamically stable patients. Compared to other imaging modalities, there is clearer demonstration of whether or not the peritoneum is intact. However penetration on CTT does not exactly correlate with organ injury.


Asunto(s)
Traumatismos Abdominales/diagnóstico por imagen , Imagen de Difusión Tensora/métodos , Tomografía Computarizada por Rayos X/métodos , Traumatismos Abdominales/cirugía , Adulto , Medios de Contraste/administración & dosificación , Femenino , Humanos , Yodo/administración & dosificación , Laparotomía , Masculino , Persona de Mediana Edad , Peritoneo/diagnóstico por imagen , Valor Predictivo de las Pruebas , Psicoterapia Breve , Estudios Retrospectivos , Sensibilidad y Especificidad , Agua , Adulto Joven
15.
JPEN J Parenter Enteral Nutr ; 41(1_suppl): 20S-23S, 2017 11.
Artículo en Inglés | MEDLINE | ID: mdl-29161210

RESUMEN

Long-term parenteral nutrition (PN) may be complicated by PN-associated liver disease (PNALD), and some studies suggest an association between the use of soy-based fat emulsions and PNALD development. Patients' liver function typically improves and PNALD resolves after reducing or stopping a soy-based fat emulsion, and thus lipid minimization has been the primary strategy for managing PNALD in many intestinal rehabilitation programs. However, fat emulsions often cannot be stopped entirely, leading some patients to develop PNALD even after lipid reduction strategies have been implemented. Smoflipid emulsion (Kabi-Fresenius, Bad Homburg, Germany), a balanced mixture of soybean oil, medium-chain triglycerides (MCTs), olive oil, and fish oil, was recently approved by the Food and Drug Administration for use in the United States as an equivalent alternative to Intralipid (Baxter Healthcare Corporation, Deerfield, IL). In several pediatric studies, patients who received Smoflipid had significantly lower serum bilirubin levels than those who received Intralipid. In this case report, we present a patient who developed severe PNALD with subsequent resolution after 20 weeks on Smoflipid.


Asunto(s)
Emulsiones Grasas Intravenosas/uso terapéutico , Enfermedades Intestinales/terapia , Intestinos/lesiones , Intestinos/trasplante , Nutrición Parenteral/efectos adversos , Traumatismos Abdominales/cirugía , Traumatismos Abdominales/terapia , Bilirrubina/sangre , Emulsiones Grasas Intravenosas/administración & dosificación , Emulsiones Grasas Intravenosas/química , Aceites de Pescado/administración & dosificación , Humanos , Enfermedades Intestinales/rehabilitación , Hepatopatías/etiología , Masculino , Aceite de Oliva/administración & dosificación , Complicaciones Posoperatorias/terapia , Aceite de Soja/administración & dosificación , Aceite de Soja/efectos adversos , Triglicéridos/administración & dosificación , Heridas por Arma de Fuego/cirugía , Adulto Joven
16.
J Pediatr Surg ; 52(5): 826-831, 2017 May.
Artículo en Inglés | MEDLINE | ID: mdl-28188036

RESUMEN

PURPOSE: An accelerated clinical care pathway for solid organ abdominal injuries was implemented at a level one pediatric trauma center. The impact on resource utilization and demonstration of protocol safety was assessed. METHODS: Data were collected retrospectively on patients admitted with blunt abdominal solid organ injuries from 2012 to 2015. Patients were subdivided into pre- and post-protocol groups. Length of hospital stay (LOS) and failure of non-operative treatment were the primary outcomes of interest. RESULTS: 138 patients with solid organ injury were studied: 73 pre- (2012-2014) and 65 post-protocol (2014-2015). There were no significant differences in age, gender, injury severity score (ISS), injury grade, or mechanism (p>0.05). LOS was shorter post-protocol (mean 5.6 vs. 3.4days; median 5 .0 vs. 3.0days; p=0.0002), resulting in average savings of $5966 per patient. Patients in the protocol group mobilized faster (p<0.0001) and experienced fewer blood draws (p=0.02). On multivariate analysis, protocol group (p<0.001) and ISS (p<0.001) were independently associated with LOS. There were no differences between groups in the need for operation, embolization, or transfusion. CONCLUSION: An accelerated care pathway is safe and effective in the management of pediatric solid organ injuries with early mobilization, less blood draws, and decreased LOS without significant morbidity and mortality. LEVEL OF EVIDENCE: Therapeutic, cost effectiveness, level III.


Asunto(s)
Traumatismos Abdominales/terapia , Vías Clínicas , Heridas no Penetrantes/terapia , Traumatismos Abdominales/diagnóstico , Traumatismos Abdominales/economía , Adolescente , Alberta , Niño , Preescolar , Análisis Costo-Beneficio/estadística & datos numéricos , Vías Clínicas/economía , Femenino , Costos de Hospital/estadística & datos numéricos , Humanos , Lactante , Recién Nacido , Puntaje de Gravedad del Traumatismo , Tiempo de Internación/estadística & datos numéricos , Masculino , Análisis Multivariante , Programas Nacionales de Salud/economía , Seguridad del Paciente/estadística & datos numéricos , Estudios Retrospectivos , Centros Traumatológicos , Resultado del Tratamiento , Heridas no Penetrantes/diagnóstico , Heridas no Penetrantes/economía
17.
J Trauma Acute Care Surg ; 82(3): 557-565, 2017 03.
Artículo en Inglés | MEDLINE | ID: mdl-28030490

RESUMEN

BACKGROUND: Acinetobacter baumannii has emerged as an increasingly important and successful opportunistic human pathogen due to its ability to withstand harsh environmental conditions, its characteristic virulence factors, and quick adaptability to stress. METHODS: We developed a clinically relevant murine model of A. baumannii traumatic wound infection to determine the effect of local wound environment on A. baumannii virulence. Mice underwent rectus muscle crush injury combined with ischemia created by epigastric vessel ligation, followed by A. baumannii inoculation. Reiterative experiments were performed using (1) a mutant deficient in the production of the siderophore acinetobactin, or (2) iron supplementation of the wound milieu. Mice were euthanized 7 days later, and rectus muscle analyzed for signs of clinical infection, HIF1α accumulation, bacterial abundance, and colony morphotype. To determine the effect of wound milieu on bacterial virulence, Galleria mellonella infection model was used. RESULTS: The combination of rectus muscle injury with ischemia and A. baumannii inoculation resulted in 100% incidence of clinical wound infection that was significantly higher compared with other groups (n = 15/group, p < 0.0001). The highest level of wound infection was accompanied by the highest level of A. baumannii colonization (p < 0.0001) and the highest degree of HIF1α accumulation (p < 0.05). A. baumannii strains isolated from injured/ischemic muscle with clinical infection displayed a rough morphotype and a higher degree of virulence as judged by G. mellonella killing assay as compared with smooth morphotype colonies isolated from injured muscle without clinical infection (100% vs. 60%, n = 30 Log-Rank test, p = 0.0422). Iron supplementation prevented wound infection (n = 30, p < 0.0001) and decreased HIF1α (p = 0.039643). Similar results of decrease in wound infection and HIF1α were obtained when A. baumannii wild type was replaced with its derivative mutant [INCREMENT]BasD deficient in acinetobactin production. CONCLUSION: The ability of A. baumannii to cause infections in traumatized wound relies on its ability to scavenge iron and can be prevented by iron supplementation to the wound milieu.


Asunto(s)
Infecciones por Acinetobacter/tratamiento farmacológico , Acinetobacter baumannii/patogenicidad , Hierro/farmacología , Infección de Heridas/tratamiento farmacológico , Infección de Heridas/microbiología , Traumatismos Abdominales/tratamiento farmacológico , Traumatismos Abdominales/microbiología , Animales , Western Blotting , Modelos Animales de Enfermedad , Ratones , Ratones Endogámicos C57BL , Mariposas Nocturnas , Recto del Abdomen/irrigación sanguínea , Recto del Abdomen/lesiones , Virulencia , Factores de Virulencia
18.
Gut Liver ; 11(1): 156-163, 2017 Jan 15.
Artículo en Inglés | MEDLINE | ID: mdl-27646597

RESUMEN

BACKGROUND/AIMS: This study investigated the protection provided by gabexate mesylate thermo-sensitive in-situ gel (GMTI) against grade III pancreatic trauma in rats. METHODS: A grade III pancreatic trauma model with main pancreatic duct dividing was established, and the pancreas anatomical diagram, ascites, and serum biochemical indices, including amylase, lipase, C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α), were examined. The pancreas was sliced and stained with hematoxylin eosin and subjected to terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining. RESULTS: Ascites, serum amylase, lipase, CRP, IL-6, and TNF-α levels were significantly increased in the pancreas trauma (PT) groups with prolonged trauma time and were significantly decreased after GMTI treatment. The morphological structure of the pancreas was loose, the acinus was significantly damaged, the nuclei were irregular and hyperchromatic, and there was inflammatory cell invasion in the PT group compared to the control. After GMTI treatment, the morphological structure of the pancreas was restored, and the damaged acinus and inflammatory cell invasion were decreased compared to the PT group. Moreover, the cell apoptosis index was significantly increased in the PT group and restored to the same levels as the control group after GMTI treatment. CONCLUSIONS: GMTI, a novel formulation and drug delivery method, exhibited specific effective protection against PT with acute pancreatitis therapy and has potential value as a minimally invasive adjuvant therapy for PT with acute pancreatitis.


Asunto(s)
Amilasas/efectos de los fármacos , Apoptosis/efectos de los fármacos , Proteína C-Reactiva/efectos de los fármacos , Gabexato/farmacología , Lipasa/efectos de los fármacos , Páncreas/efectos de los fármacos , Factor de Necrosis Tumoral alfa/efectos de los fármacos , Traumatismos Abdominales/complicaciones , Amilasas/metabolismo , Animales , Ascitis/etiología , Proteína C-Reactiva/metabolismo , Edema/etiología , Edema/metabolismo , Edema/patología , Geles/farmacología , Etiquetado Corte-Fin in Situ , Interleucina-6/metabolismo , Lipasa/metabolismo , Masculino , Páncreas/lesiones , Páncreas/metabolismo , Páncreas/patología , Ratas , Ratas Sprague-Dawley , Factor de Necrosis Tumoral alfa/metabolismo
19.
Burns ; 42(7): 1588-1592, 2016 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-27156790

RESUMEN

INTRODUCTION: Moxibustion, a traditional Chinese treatment that uses dried Artemisia argyi, is a common cause of burns treated in Korean hospitals. We aimed to examine the characteristics of moxibustion-induced burns. METHODS: This retrospective study examined the records of 59 patients who were treated for moxibustion-induced burns (April 2014-October 2015). All patients completed a questionnaire regarding their general characteristics and moxibustion use. RESULTS: The patients included 16 men and 43 women (average age: 49.1 years, 68 burn sites). Superficial second-degree burns were present at 21 sites, deep second- or third-degree burns at 44 sites, and unknown burns at 3 sites. The most common sites were the lower extremities, abdomen, and upper extremities. The most common practitioners were the patients (27/59, 45.7%) and Oriental medicine practitioners (23/59, 38.9%). The most common locations were the patient's home, Oriental medicine clinic, and moxibustion clinic. The most common reason for moxibustion was pain. Only the burn site was significantly associated with burn depth, and non-abdominal sites were 9.37-fold more likely to involve deep burns (vs. abdominal sites). CONCLUSION: Korean patients routinely undergo moxibustion, and care must be taken when using moxibustion at non-abdominal sites, due to the risk of deep burns.


Asunto(s)
Traumatismos Abdominales/epidemiología , Traumatismos del Brazo/epidemiología , Quemaduras/epidemiología , Traumatismos de la Pierna/epidemiología , Moxibustión/efectos adversos , Traumatismos Abdominales/etiología , Adulto , Anciano , Traumatismos del Brazo/etiología , Quemaduras/etiología , Niño , Femenino , Humanos , Traumatismos de la Pierna/etiología , Masculino , Persona de Mediana Edad , Manejo del Dolor , República de Corea/epidemiología , Estudios Retrospectivos , Encuestas y Cuestionarios , Índices de Gravedad del Trauma
20.
J Laparoendosc Adv Surg Tech A ; 26(1): 27-31, 2016 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-26650436

RESUMEN

BACKGROUND: In many trauma centers there is an ongoing controversy over the way of managing patients with penetrating abdominal injuries. This study was constructed to evaluate the role of diagnostic laparoscopy performed with local anesthesia for the management of penetrating abdominal injury. PATIENTS AND METHODS: Thirty hemodynamically stable patients with a penetrating stab wound in the anterior abdominal wall were included in this study after consent was obtained. Laparoscopic explorations were done with the patient having local anesthesia. If there was bleeding or intestinal content in the peritoneal cavity or visible injury to any abdominal organ, the procedure was converted to open exploration. If the peritoneal cavities showed no fluid and there was no injury to the abdominal viscera, the patient was followed up for the next 72 hours. Continuous variables were expressed as mean and standard deviation values. Categorical variables were expressed as frequencies and percentages. Student's t test was used to assess the statistical significance of the difference between the two study groups' means. Fisher's exact test was used to examine the relationship between categorical variables. A significance level of P < .05 was used in all tests. All statistical procedures were carried out using SPSS version 20 for Windows software (IBM, Armonk, NY). RESULTS: From the total of 30 patients who underwent laparoscopic exploration, 13 patients (43.3%) needed open exploration: 11 cases had intrabdominal organ injuries that needed laparotomy, 1 case had intraperitoneal blood collection where the only source of blood was the anterior abdominal wall wound, and 1 case had acute abdominal pain after 48 hours of negative laparoscopic exploration, in which an intestinal tear was found upon re-exploration. For the other 17 (56.7%) cases, 3 cases had no peritoneal penetration, whereas 14 cases had peritoneal penetration without any internal organ injuries, and these patients were followed up and discharged after 2-3 days. CONCLUSIONS: Laparoscopy performed with the patient having local anesthesia is an accurate diagnostic tool in the management of patients with an equivocal penetrating stab wound in the abdominal wall and can reduce the number of patients with negative open exploration.


Asunto(s)
Traumatismos Abdominales/diagnóstico , Laparoscopía/métodos , Heridas Penetrantes/diagnóstico , Traumatismos Abdominales/fisiopatología , Traumatismos Abdominales/cirugía , Adulto , Anestesia Local , Femenino , Estudios de Seguimiento , Hemodinámica , Humanos , Masculino , Persona de Mediana Edad , Heridas Penetrantes/fisiopatología , Heridas Penetrantes/cirugía
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