[The anticytolytic activity of ubiquinone-10 in a liver lesion from chlorinated hydrocarbons]. / Antitsitoliticheskaia aktivnost' ubikhinona-10 pri porazhenii pecheni khlorirovannymi uglevodorodami.

Antioxidative activity of ubiquinone-10, exceeding the level of that of vitamin E more than five times and anticytolytic activity of vitamin E and particularly of ubiquinone-10 manifested in decreasing activities of blood serum alanine aminotransferase and histidineammoniumlyase, which might be determined only during toxic liver damage, have been demonstrated. The activity of histidineammoniumlyase was considerably decreased under the effect of vitamin E and particularly in the presence of ubiquinone-10. Decreasing of activity of blood serum enzyme markers of cytolysis of hepatocytes is connected with the hepatocytes biomembrane stabilizing effect of antioxidants which was confirmed by the electron microscope investigation method. The evidence of safety of intact cellular and subcellular membranes and activation of compensative and regenerative processes in hepatocytes was also represented.

The spectrum of poisonings in Hong Kong: an overview.

Poisoning is an important health problem in Hong Kong. In 1990 alone, 6500 patients were treated in Hong Kong hospitals and there were 245 deaths. Two hospital-based studies indicated that exposures to poisons were intentional in the majority (96%) of adult cases, with hypnotics/sedatives (34%), household products (16%) and analgesics (14%) being most often used. Apart from drugs and chemicals, accidental poisoning may occur after the ingestion of Chinese medicines or vegetables contaminated with methamidophos. The former may contain highly toxic aconitine or podophyllin, declared and undeclared western drugs such as phenylbutazone and aminopyrine, and heavy metals. It is important that there be a continuing effort to collect information on the factors leading to and the pattern of poisonings in Hong Kong and other Southeast Asian countries. This is particularly valuable for childhood poisoning so that appropriate preventive measures can be taken.

[Experimental antioxidant therapy in toxic liver damage from CCl4 and chloxyl]. / Eksperimental'naia terapiia antioksidantami pri toksicheskom povrezhdenii pecheni CCl4 i khloksilom.

The authors studied the pharmacotherapeutic efficacy of antioxidants vitamin E, sodium selenite, and their combination in damage to rat liver by CCl4 and the anthelmintic agent chloxyl. Changes of the intensity of peroxidation of biological membrane lipids, the activity of enzymes-markers of hepatocyte cytolysis--alanine aminotransferase and aspartate aminotransferase--in blood serum, and changes in the structure of the liver were studied. Antioxidants and their combination blocked lipid peroxidation, reduced the activity of alanine aminotransferase and aspartate aminotransferase in blood serum considerably, and caused a protective effect on the structure of rat liver in its damage by CCl4 and chloxyl.

[Possibility of studying morphofunctional characteristics of interglandular relations within the neuroendocrine system based on multifactorial analysis by the spline method]. / O vozmozhnosti morfofunktsional'noi kharakteristiki mezhzhelezistykh vzaimootnoshenii neiroendokrinnoi sistemy na osnove izucheniia mnozhestvennykh zavisimostei splain- metodom.

The possibility of morphofunctional characteristics of interglandular relations in the neuroendocrine system is shown by the study of non-linear multiple dependencies, by means of splines, of the effects of aromatic hydrocarbons. The method can be recommended for a total systems approach to the study of functional-morphological alterations of the adaptation processes and homeostasis normalization.