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1.
J Immigr Minor Health ; 26(3): 527-538, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38334856

RESUMEN

We conducted an analysis to identify factors influencing the use of traditional complementary and alternative medicine (TCAM), with a particular emphasis on ethnic variations. Using the 2015 Asian American Quality of Life survey (N = 2,609), logistic regression analyses were performed, considering acculturation, health status, healthcare accessibility/utilization, and socio-demographic factors. Ethnicity, specifically being Chinese or Korean Americans, having chronic medical conditions, experiencing unmet healthcare needs, and having regular check-ups were significant predictors of TCAM use among Asian Americans as a whole. However, when we delved into sub-ethnic groups, different patterns were found. Among Vietnamese and Filipino Americans, having unmet healthcare needs emerged as the most prominent predictor of TCAM use. Furthermore, acculturation level and English proficiency were significant in predicting Vietnamese and Filipino Americans' TCAM use, with the direction varying by sub-ethnicity. Being old emerged as a predictor of TCAM use for Chinese, Indian, Korean, and 'other' Americans. Our findings underscore the importance of adopting an ethnically sensitive approach when addressing the healthcare needs of diverse Asian American populations.


Asunto(s)
Aculturación , Asiático , Terapias Complementarias , Humanos , Asiático/estadística & datos numéricos , Femenino , Masculino , Terapias Complementarias/estadística & datos numéricos , Persona de Mediana Edad , Adulto , Anciano , Estados Unidos , Factores Socioeconómicos , Estado de Salud , Accesibilidad a los Servicios de Salud , Factores de Edad , Aceptación de la Atención de Salud/etnología , Factores Sociodemográficos , Adulto Joven , Vietnam/etnología , Filipinas/etnología , Calidad de Vida , Etnicidad/estadística & datos numéricos
2.
BMC Biotechnol ; 23(1): 36, 2023 09 08.
Artículo en Inglés | MEDLINE | ID: mdl-37684623

RESUMEN

BACKGROUND: Lamotrigine is an effective antiseizure medication that can be used in the management of focal and generalized epilepsies in pediatric patients. This study was conducted to quantify and compare the solubility of lamotrigine in age-specific biorelevant media that simulated the fasted and fed conditions of the gastric and intestinal environments in pediatrics and adults. Another aim was to predict how traditional, re-formulated, modified, and new oral formulations would behave in the gastric and intestinal environments across different age groups. METHODS: Solubility studies of lamotrigine were conducted in 16 different age-specific biorelevant media over the pH range and temperature specified by the current biopharmaceutical classification system-based criteria. The age-specific biorelevant media simulated the environments in the stomach and proximal gastrointestinal tract in both fasted and fed conditions of adults and pediatric sub-populations. The solubility of lamotrigine was determined using a pre-validated HPLC-UV method. RESULTS: Lamotrigine showed low solubility in the 16 age-specific biorelevant media as indicated by a dose number of > 1. There were significant age-specific variabilities in the solubility of lamotrigine in the different age-specific biorelevant media. Pediatric/adult solubility ratios of lamotrigine fell outside the 80-125% range in 6 (50.0%) and were borderline in 3 (25.0%) out of the 12 compared media. These ratios indicated that the solubility of lamotrigine showed considerable differences in 9 out of the 12 (75.0%) of the compared media. CONCLUSION: Future studies are still needed to generate more pediatric biopharmaceutical data to help understand the performances of oral dosage forms in pediatric sub-populations.


Asunto(s)
Productos Biológicos , Estómago , Adulto , Humanos , Niño , Lamotrigina , Solubilidad , Factores de Edad
3.
Medicine (Baltimore) ; 102(34): e34723, 2023 Aug 25.
Artículo en Inglés | MEDLINE | ID: mdl-37653748

RESUMEN

The immune system is affected by psychosocial stimuli and plays a major role in the development of various diseases. Psychoneuroimmunology (PNI)-based interventions may positively influence the disease course; however, the impact of PNI research findings on clinical practice differs depending on the medical specialties involved. A comprehensive overview of the use of PNI research findings in clinical practice is currently lacking. This exploratory study aimed to provide insight into the dissemination of PNI research findings and their practical applications among clinical practitioners. Data was collected from 50 physicians using an ad hoc online questionnaire. We invited participants to take part in our online survey via an article in the DocCheck Newsletter, a German-language newsletter for physicians. Bivariate nonparametric correlation analysis (Spearman correlation) were used to explore the relationship between independent variables (age, sex, medical specialty, professional experience, and clinical environment) and dependent variables (six questionnaire items concerned with awareness, relevance, and utilization of PNI concepts). While 46% of respondents believed that PNI research findings were relevant to patient treatment, only 22% used PNI-based interventions as part of their therapeutic regimen. Furthermore, 90% of participants could not refer their patients to therapists offering PNI-based interventions. Moderately positive correlations were identified between the increasing age (rs = .48, P < .001) and increasing amount of professional experience (rs = .34, P = .02) of study participants and awareness of the theoretical foundations of PNI research. Although there is some awareness of PNI among medical practitioners, there appears to be a clear barrier inhibiting the implementation of research findings in current treatment practices. Therefore, it is necessary to examine the impact of increasing age and professional experience on the utilization of PNI-based interventions in patient care.


Asunto(s)
Psiconeuroinmunología , Medicina Psicosomática , Psiconeuroinmunología/estadística & datos numéricos , Humanos , Encuestas y Cuestionarios , Masculino , Femenino , Adulto Joven , Adulto , Persona de Mediana Edad , Anciano , Factores de Edad , Medicina Psicosomática/estadística & datos numéricos , Médicos , Alemania
4.
Haemophilia ; 29(5): 1359-1365, 2023 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-37639381

RESUMEN

INTRODUCTION: Joint health is one of the most important factors contributing to a healthy life in patients with haemophilia. Recent study revealed that starting early prophylaxis was not enough to prevent joint disease in most paediatric patients with haemophilia. AIM: In this study, we aimed to determine the age-specific incidence of acute joint disease during childhood at single haemophilia treatment centre (HTC). METHOD: The joint health in 48 patients was evaluated based on consecutive US testing for 5 years at annual multidisciplinary comprehensive care. RESULTS: During the study period, 23 patients (47.9%) had no joint disease since the initial examination, whereas 13 patients (27.0%) showed development from negative to positive findings. The incidence of joint disease increased with age: 0% in preschool, 5.3% in elementary school, 14.3% in junior high school and 35% beyond high school age. Among the 13 patients who developed joint disease, two experienced acquired synovitis that resolved during the follow-up period. Statistical analysis revealed that the patients who routinely underwent follow-up by the HTC exhibited a significantly lower incidence of joint disease than did those followed up at other institutions (p < .001). CONCLUSION: These results indicated that close check-up, including routine joint examination using US as well as frequent assessment of pharmacokinetic profile at the HTC, might play an important role in avoiding joint disease among paediatric patients with haemophilia.


Asunto(s)
Hemofilia A , Artropatías , Sinovitis , Humanos , Niño , Preescolar , Hemofilia A/complicaciones , Hemofilia A/epidemiología , Incidencia , Artropatías/complicaciones , Artropatías/epidemiología , Factores de Edad
5.
Distúrb. comun ; 35(2): 55472, 02/08/2023.
Artículo en Inglés, Portugués | LILACS | ID: biblio-1444735

RESUMEN

Objetivo: verificar se a idade das crianças com Trissomia do 21 e o tempo de uso por dia da placa palatina de memória influenciam a adaptação da criança à placa, as mudanças miofuncionais orofaciais percebidas pelos pais e a satisfação da família, após quatro meses de tratamento. Métodos: participaram do estudo14 pais ou responsáveis legais de crianças com Trissomia do 21, com idades de 3 a 20 meses. O tratamento com a placa palatina de memória foi realizado durante quatro meses. A adaptação da criança à placa, as mudanças miofuncionais orofaciais percebidas pelos pais e a satisfação das famílias em relação ao tratamento foram investigadas por meio de questionário elaborado pelos autores da pesquisa e respondido pelas mães após quatro meses de tratamento. Resultados: a média de idade das crianças que participaram do estudo foi 10 meses e o desvio-padrão de 4,9 meses. O resultado do questionário indicou associação entre idade e postura de lábios relatada pelos pais com o uso da placa palatina de memória, sendo que todas as crianças menores de 10 meses mantiveram o selamento labial, de acordo com os pais, durante o uso da placa; bem como entre idade e satisfação com o tratamento, sendo que as mães das crianças menores mostraram-se mais satisfeitas. Conclusão: os resultados do estudo indicam que houve associação entre idade e postura de lábios relatada pelos pais com o uso da placa, bem como entre idade e satisfação com o tratamento e sugerem que o tratamento precoce com a placa palatina de memória beneficia as crianças com Trissomia do 21. (AU)


Purpose: to verify if the age of children with Trisomy 21 and the time of use per day of the stimulating palatal plate influence the child's adaptation to the plate, the orofacial myofunctional changes perceived by the parents, and the family's satisfaction, after four months of treatment. Methods: 14 parents or legal guardians of children with Trisomy 21, aged between 3 and 20 months, participated in the study. Treatment with the stimulating palatal plate was carried out for four months. The child's adaptation to the plate, the orofacial myofunctional changes perceived by the parents, and the families' satisfaction with the treatment were investigated through a questionnaire prepared by the research authors and answered by the mothers after four months of treatment. Results: The mean age of the children who participated in the study was 10 months and the standard deviation was 4.9 months. The results of the questionnaire indicated an association between age and lip posture, reported by parents, during the use of the stimulating palatal plate, and all children under 10 months maintained lip closure, according to the parents, during the use of the plate. Age was also associated with satisfaction with the service, as the mothers of younger children were more satisfied. Conclusion: The study results indicate an association between age and lip posture, reported by the parents, during the use of the plate, and between age and satisfaction with the service. Thus, it suggests that early treatment with the stimulating palatal plate benefits children with Trisomy 21. (AU)


Objetivo: verificar si la edad de los niños con Trisomía 21 y el tiempo de uso por día de la placa palatina de memoria influyen en la adaptación del niño a la placa, los cambios miofuncionales orofaciales percibidos por los padres y la satisfacción de la familia, después de cuatro meses de tratamiento. Métodos: Participaron en el estudio 14 padres o tutores legales de niños con trisomía 21, con edades comprendidas entre los 3 y los 20 meses. El tratamiento con la placa de memoria palatina se llevó a cabo durante cuatro meses. La adaptación del niño al plato, los cambios miofuncionales orofaciales percibidos por los padres y la satisfacción de las familias con el tratamiento fueron investigados a través de un cuestionario elaborado por los autores y respondido por las madres, después de cuatro meses de tratamiento. Resultados: La edad media de los niños que participaron en el estudio fue de 10 meses y la desviación estándar fue de 4,9. El resultado del cuestionario indicó una asociación entre la edad y la postura de los labios, reportada por los padres, con el uso de la placa de memoria palatina, y todos los niños menores de 10 meses mantuvieron el sello de los labios, según los padres, durante el uso de la placa de memoria palatina, así como entre la edad y la satisfacción con el servicio. Las madres de niños más pequeños estaban más satisfechas. Conclusión: Los resultados del estudio indican que hubo asociación entre la edad y la postura de los labios, reportada por los padres, con el uso de la placa, así como entre la edad y la satisfacción con el servicio, y sugieren que el tratamiento temprano con la placa de memoria palatina beneficia a los niños con trisomía 21. (AU)


Asunto(s)
Humanos , Masculino , Femenino , Lactante , Técnica de Expansión Palatina , Factores de Edad , Satisfacción del Paciente , Estudios Transversales , Encuestas y Cuestionarios , Síndrome de Down , Terapia Miofuncional , Anomalías de la Boca/rehabilitación
6.
J Cardiol ; 82(6): 455-459, 2023 12.
Artículo en Inglés | MEDLINE | ID: mdl-37459964

RESUMEN

BACKGROUND: n-3 polyunsaturated fatty acids (PUFAs) reduce the risk of ischemic heart disease. However, there are few reports of a relationship between n-3 PUFAs and coronary spastic angina (CSA). This study aimed to assess the age-dependent role of serum levels of fatty acid in patients with CSA. METHODS AND RESULTS: We enrolled 406 patients who underwent ergonovine tolerance test (ETT) during coronary angiography for evaluation of CSA. All ETT-positive subjects were diagnosed as having CSA. We categorized the patients by age and results of ETT as follows: (1) young (age ≤ 65 years) CSA-positive (n = 32), (2) young CSA-negative (n = 134), (3) elderly (age > 66 years) CSA-positive (n = 36), and (4) elderly CSA-negative (n = 204) groups. We evaluated the serum levels of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid, and dihomo-gamma-linolenic acid. In the young groups, the serum levels of EPA (64.3 ±â€¯37.7 µg/mL vs. 49.4 ±â€¯28.8 µg/mL, p = 0.015) and DHA (135.7 ±â€¯47.6 µg/mL vs. 117.4 ±â€¯37.6 µg/mL, p = 0.020) were significantly higher in the CSA-positive group than in the CSA-negative group, respectively. However, this was not the case with elderly groups. In the multivariate analysis in young groups, the serum levels of EPA (p = 0.028) and DHA (p = 0.049) were independently associated with the presence of CSA, respectively. CONCLUSION: Our results suggested that the higher serum levels of EPA and/or DHA might be involved in the pathophysiology of CSA in the young population but not in the elderly population.


Asunto(s)
Angina de Pecho , Vasoespasmo Coronario , Pueblos del Este de Asia , Ácidos Grasos Insaturados , Anciano , Humanos , Ácidos Docosahexaenoicos/sangre , Ácido Eicosapentaenoico/sangre , Ácidos Grasos , Ácidos Grasos Omega-3/sangre , Ácidos Grasos Insaturados/sangre , Angina de Pecho/etiología , Vasoespasmo Coronario/sangre , Vasoespasmo Coronario/inducido químicamente , Vasoespasmo Coronario/diagnóstico por imagen , Factores de Edad , Ergonovina/efectos adversos , Vasoconstrictores/efectos adversos , Angiografía Coronaria , Persona de Mediana Edad
7.
Rev. Hosp. Ital. B. Aires (2004) ; 43(2): 72-78, jun. 2023. tab
Artículo en Español | LILACS, UNISALUD, BINACIS | ID: biblio-1510623

RESUMEN

Introducción: el judo es un deporte de combate cuya clasificación competitiva depende del peso corporal, lo cual está destinado a promover competencias parejas y equitativas en cuanto a capacidades físicas se refiere. El avance de las ciencias del entrenamiento y de la nutrición deportiva generó una mejora de la composición corporal en los deportistas, redundando en un aumento de los valores de masa muscular y en una disminución de la masa adiposa. El objetivo del estudio fue estimar la composición corporal de las personas que practican Judo participantes del campeonato nacional argentino del año 2021. Materiales y métodos: se realizó un estudio transversal descriptivo a los/as participantes del campeonato nacional de judo del año 2021. Fueron evaluados un total de 183 judocas (51 mujeres y 132 varones), según el protocolo de medición de la ISAK. Para la determinación de la composición corporal se utilizó el método de fraccionamiento anatómico de cinco componentes de Kerry Ross. Resultados: el promedio de las judocas fue de 30,5% para la masa adiposa y de 44,5% para la masa muscular; no se encontraron diferencias estadísticamente significativas en los distintos grupos de edad. Los varones obtuvieron un valor promedio de 22,4% para la masa adiposa y 49,1%para la masa muscular; en este caso se encontraron diferencias significativas entre los distintos grupos de edad, tanto para la masa adiposa como para la muscular y la masa ósea. Discusión: se necesitan más estudios con grupos estratificados en función de la división de peso corporal para poder establecer patrones de referencia específicos para el trabajo en ciencias del ejercicio y la nutrición. Conclusión: la optimización de la composición corporal de las personas que practican Judo redunda positivamente en la mejora de las capacidades físicas específicas. Los datos presentados constituyen una referencia específica de utilidad para la evaluación y seguimiento de las personas que practican Judo. La estratificación por grupos etarios y división de peso corporal permitirá delimitar mejor aún los valores de cada categoría de edad. Se considera relevante vincular la composición corporal con las pruebas físicas y los resultados deportivos, a fin de establecer un mejor perfil del judoca argentino. (AU)


Introduction: judo is a combat sport whose competitive classification depends on body weight, intended to promote even and equitable compe-titions in terms of physical abilities. Advances in the sciences of training and sports nutrition have led to an improvement in the body composition of athletes, resulting in an increase in muscle mass and a decrease in adipose mass. This study aimed to estimate the body composition of judo fighters participating in the 2021 Argentine National Championship. Materials and methods: we conducted a descriptive cross-sectional study of participants of the 2021 national judo championship. We evaluated 183 judokas (51 women and 132 men) applying the ISAK measurement protocol. We used the Kerry Ross five-component fractional anatomic method to determine body composition. Results: the average for female judo players was 30.5% for adipose mass and 44.5% for muscle mass; we found no statistically significant diffe-rences in the different age groups. The average value for males was 22.4% for adipose mass and 49.1% for muscle mass; in this case, we found significant differences between the different age groups for adipose mass and muscle and bone mass. Discussion: there is a need for more studies with stratified groups according to body weight division to establish specific reference standards for the work in exercise science and nutrition. Conclusion: the optimization of the body composition of female and male judo players has a positive effect on the improvement of specific physical capacities. The data presented constitute a relevant reference for the evaluation and follow-up of judokas. The stratification by age groups and body weight division will allow a better delimitation of the values of each age category. Linking body composition with physical tests and results is considered relevant to obtain a better profile of the Argentinian judo player. (AU)


Asunto(s)
Humanos , Masculino , Femenino , Adolescente , Adulto , Adulto Joven , Composición Corporal , Antropometría , Artes Marciales/estadística & datos numéricos , Atletas/estadística & datos numéricos , Argentina , Peso Corporal , Tejido Adiposo , Factores de Edad , Músculos
8.
J Pak Med Assoc ; 73(Suppl 2)(2): S109-S112, 2023 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-37096716

RESUMEN

Objectives: To investigate factors associated with hypertension in women of childbearing age. Method: The correlational, cross-sectional study was done in Madiun, East Java, Indonesia, in August 2021 after approval from the Faculty of Nursing, Universitas Airlangga, Surabaya, Indonesia. The sample comprised women of childbearing age who were married and not pregnant. Data was collected using questionnaires, while blood pressure, height and weight of the subjects were measured and noted. Data were analysed using Spearman Rho test. RESULTS: Of the 311 subjects with mean age 32.06±7.10 years, 184(59.2%) were housewives; 153(49.2%) had studied up to the Senior High School level; 166(53.38%) were overweight; 157(50.48%) had family history of hypertension; 99 (31.83%) were exposed to cigarette 1-2 hours a day; 141(45.34%) were using hormonal contraception for >2 years; 94(30.23%) had low physical activity; 148 (47.59%) had high sodium consumption; and 139(44.69%) consumed coffee 2-3 cup/day. Hypertension prevalence was 123(39.55%). BMI (r=0.750), family history (r=0.763), exposure to cigarette smoke (r=0.755), physical activity level (r=-0.806), and sodium (r=0.505) were significantly associated with hypertension (p<0.05). Hormonal contraception (r=0.271) and coffee consumption (r= 0.127) had a weak association with hypertension incidence (p>0.05). CONCLUSIONS: Risk of hypertension in women increased for those with high body mass index, family history, high exposure to cigarette smoke, and high sodium intake.


Asunto(s)
Café , Hipertensión , Humanos , Embarazo , Femenino , Adulto Joven , Adulto , Estudios Transversales , Sobrepeso/epidemiología , Índice de Masa Corporal , Hipertensión/epidemiología , Sodio , Factores de Edad , Factores de Riesgo
9.
Percept Mot Skills ; 130(3): 1168-1184, 2023 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-36992665

RESUMEN

This study was conducted to determine whether the relative age effect (RAE) is present in different age groups, weight categories, sexes, and across different time frames in international-level judo competition. A total of 9451 judo athletes competing at the Olympic Games and/or World Championships in the Cadet, Junior and/or Senior age groups between 1993 and 2020 were considered. Athletes' birthdate distributions were grouped in four quartiles (Q1: January-March; Q2: April-June; Q3: July-September; Q4: October-December) and compared to a day-corrected theoretical distribution using Chi-squared analysis. Poisson regression was also used to evaluate the ability to explain weekly birth count. RAE was more prevalent in males than females (p < .05), and for Cadets and Juniors compared to Seniors (p < .05). Heavyweight and middleweight categories presented RAEs in Senior and Junior males, while for females it was present in Cadet heavyweights (p < .05). RAE was more prevalent in recent years (2009-2021) for Senior male judo athletes (p < .05). Poisson analysis illustrated some nuanced information, including RAE detection during an earlier time frame, not readily apparent with the traditional analysis.


Asunto(s)
Rendimiento Atlético , Artes Marciales , Femenino , Humanos , Masculino , Factores de Edad , Atletas
10.
J Phys Act Health ; 20(3): 239-249, 2023 03 01.
Artículo en Inglés | MEDLINE | ID: mdl-36746154

RESUMEN

BACKGROUND: Tai Ji Quan (TJQ) has broad appeal to people of all ages and backgrounds. This study aimed to examine a variety of individual and environmental factors in the dissemination of TJQ to diverse practicing communities in China. METHODS: A mixed-methods approach was utilized in the research design. Quantitative data were collected via an online survey using a national sample (N = 737), whereas qualitative data came from focus groups and in-depth interviews. Analysis was performed along the RE-AIM dimensions of reach, efficacy, adoption, implementation, and maintenance. RESULTS: We divided TJQ experience into 4 distinct categories (nonlearners, current learners, quitters, and retainers) and observed significant patterns of variation along lines of occupation groups and age cohorts. A significant male/female difference was detected in TJQ experience among college students but not the general public, and having practicing family members was an important predictor of personal TJQ history. Varied TJQ experience has a significant impact on perceptions of TJQ's miscellaneous values as well as level of satisfaction with its health outcomes. CONCLUSIONS: Both individual (personal) and environmental (settings) factors are important in shaping personal decisions in TJQ engagement. An ecological approach coordinating individual factors and settings resources is essential in promoting TJQ to the general population.


Asunto(s)
Estudiantes , Taichi Chuan , Femenino , Humanos , Masculino , Factores de Edad , China/epidemiología , Ambiente , Ejercicio Físico/estadística & datos numéricos , Internet , Características de la Residencia/estadística & datos numéricos , Factores Sexuales , Estudiantes/estadística & datos numéricos , Encuestas y Cuestionarios , Taichi Chuan/métodos , Taichi Chuan/estadística & datos numéricos
11.
Low Urin Tract Symptoms ; 15(2): 38-49, 2023 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-36507559

RESUMEN

OBJECTIVES: To investigate the age-specific effect of transurethral holmium laser enucleation of the prostate (HoLEP) on overactive bladder (OAB). METHODS: A total of 186 consecutive patients who underwent HoLEP were included. They were divided into three groups: patients aged less than 65 years, between 65 and 74, and 75 or older. The OAB symptom score as well as other relevant variables of lower urinary tract symptoms and function were assessed before and 1, 3, 6, and 12 months after surgery. Age-specific prevalence of OAB, the proportion of resolution of OAB, and de novo OAB were evaluated. RESULTS: The mean age of patients was 70.7 years, and the mean total prostate volume was 75.8 ml. The mean OAB symptom scores before surgery of patients aged less than 65 years, between 65 and 74, and 75 or older were 6.0, 5.2, and 5.7, respectively. At 12 months after surgery, the scores for the respective groups had significantly decreased to 2.1, 2.5, and 3.5. The prevalence of OAB based on the score in the respective groups was 45.8%, 56.9%, and 54.0% (p = .6391) preoperatively and 9.1%, 11.3%, and 15.8% at 12 months after the surgery (p = .7613). Of those with preoperative OAB, 75.0%, 79.2%, and 75.0% of the respective groups showed resolution of OAB at 12 months postoperatively (p = .9427). CONCLUSIONS: In candidates for surgical deobstruction of benign prostatic hyperplasia, HoLEP has potential to improve OAB symptoms regardless of age.


Asunto(s)
Terapia por Láser , Láseres de Estado Sólido , Hiperplasia Prostática , Resección Transuretral de la Próstata , Vejiga Urinaria Hiperactiva , Masculino , Humanos , Anciano , Próstata/cirugía , Hiperplasia Prostática/cirugía , Factores de Edad , Resultado del Tratamiento
12.
Curr Pediatr Rev ; 19(4): 388-394, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36411551

RESUMEN

All neonates experience a downtrend in their hematocrit values immediately following the birth through normal falls in erythropoietin (Epo) production, transition to adult hemoglobin, and hemodilution with somatic growth. However, this drop is more pronounced in critically ill and preterm neonates and can lead to potentially pathologic anemia that impairs tissue oxygen delivery. In this review, we highlight the mechanisms underlying physiologic anemia and anemia of prematurity and briefly review the evidence for the treatment of anemia in the neonatal population, including the use of red blood cell transfusions, erythropoietic stimulating agents, and iron supplementation.


Asunto(s)
Anemia Neonatal , Eritropoyetina , Hematínicos , Recién Nacido , Humanos , Recién Nacido de Bajo Peso , Factores de Edad , Recien Nacido Prematuro , Eritropoyetina/uso terapéutico , Anemia Neonatal/diagnóstico , Anemia Neonatal/terapia
13.
Span J Psychol ; 25: e26, 2022 Oct 10.
Artículo en Inglés | MEDLINE | ID: mdl-36210368

RESUMEN

We investigated the interrelations between chronological age, theory of mind (ToM), Yield (as a measure of individual suggestibility), memory and acceptance of experimental suggestion in a sample of children between 3 and 7 years old (N = 106). One week after participants interacted with 'a Teacher', they were asked to recall activities carried out with the Teacher (direct experience) and the contents of a story read to them by the Teacher (indirect experience). Data were examined with an analysis of developmental trajectories, which allows establishing the predictor value of socio-cognitive developmental factors regardless of participants' chronological age. It also estimates predictor values in interaction with the age and determines whether age is the best predictor for performance. As in previous research, results showed that chronological age was the main predictor of memory performance, both for direct experience (i.e., activities performed) and indirect experience (i.e., contents of the story). However, ToM and Yield, together with participants' ages, modulated their acceptance of the external suggestions received (presented only once, one week after the event). A turning point was observed at age 4.6. Below this age, the greater the mentalist skills (higher ToM), the lower was the vulnerability to external suggestion. Still, children below this age characterized individually as being suggestible (Yield medium or high) were more vulnerable to suggestion the younger they were. Thus, developmental socio-cognitive factors might modulate young children's vulnerability to external suggestions, even if received only once.


Asunto(s)
Teoría de la Mente , Factores de Edad , Niño , Preescolar , Cognición , Humanos , Recién Nacido , Recuerdo Mental , Sugestión
14.
J Speech Lang Hear Res ; 65(11): 4404-4416, 2022 11 17.
Artículo en Inglés | MEDLINE | ID: mdl-36251884

RESUMEN

PURPOSE: Studies of speech and text interruption indicate that the interruption rate influences the perceptual information available, from whole words at slow rates to subphonemic cues at faster interruptions rates. In young adults, the benefit obtained from text supplementation of speech may depend on the type of perceptual information available in either modality. Age commonly reduces temporal aspects of information processing, which may influence the benefit older adults obtain from text-supplemented speech across interruption rates. METHOD: Older adults were tested unimodally and multimodally with spoken and printed sentences that were interrupted by silence or white space at various rates. RESULTS: Results demonstrate U-shaped performance-rate functions for all modality conditions, with minimal performance around interruption rates of 2-4 Hz. Comparison to previous studies with younger adults indicates overall poorer recognition for interrupted materials by the older adults. However, as a group, older adults can integrate information between the two modalities to a similar degree as younger adults. Individual differences in multimodal integration were noted. CONCLUSION: Overall, these results indicate that older adults, while demonstrating poorer overall performance in comparison to younger adults, successfully combine distributed partial information across speech and text modalities to facilitate sentence recognition.


Asunto(s)
Percepción del Habla , Habla , Adulto Joven , Humanos , Anciano , Reconocimiento en Psicología , Factores de Edad , Suplementos Dietéticos
15.
JAMA Netw Open ; 5(5): e229706, 2022 05 02.
Artículo en Inglés | MEDLINE | ID: mdl-35499828

RESUMEN

Importance: The recommendations for the age and frequency that women at average risk for breast cancer should undergo breast cancer mammography screening have been a matter of emotional, political, and scientific debate over the past decades. Multiple national organizations provide recommendations for breast cancer screening age and frequency. US Centers for Disease Control and Prevention (CDC) funding for state comprehensive cancer control (CCC) planning requires compliance with stated objectives for attaining goals. US Preventive Services Task Force (USPSTF) recommendations on cancer prevention and control are currently used to require coverage of prevention services. Objectives: To evaluate the consistency of state CCC plan objectives compared with the most current (2016) USPSTF recommendations for the age and frequency that individuals should undergo mammography screening and to make recommendations for improvement of state CCC plans. Design, Setting, and Participants: This cross-sectional study used a descriptive, point-in-time evaluation and was conducted from November 1, 2019, to June 30, 2021. In November 2019, the most recent CCC plans from 50 US states and the District of Columbia were downloaded from the CDC website. The recommended ages at which to begin and end mammography examinations and the frequency of mammography examinations were extracted from plan objectives. Main Outcomes and Measures: The recommendations found in CCC plan objectives regarding the ages at which to begin and end mammography examinations and the frequency of mammography examinations for women with average risk for breast cancer were compared with USPSTF recommendations. Results: Of the 51 CCC plans, 16 (31%) were consistent with all USPSTF recommendations for age and frequency that women at average risk should undergo mammography. Twenty-six plans (51%) were partially consistent with recommendations, and 9 plans (18%) were not consistent with any of the 3 guideline components. Conclusions and Relevance: Compared with the USPSTF recommendation, state CCC plans are not homogenous regarding the age and frequency that women at average risk for breast cancer should undergo mammography. This variation is partially due to differences in state-specific planning considerations and discretion, variations in recommendations among national organizations, and publication of plans prior to the most current USPSTF recommendation (2016). Specifying the concept that high-risk populations need different age and frequency of screening recommendations than the general population may reduce heterogeneity among plans.


Asunto(s)
Neoplasias de la Mama , Mamografía , Factores de Edad , Neoplasias de la Mama/diagnóstico por imagen , Neoplasias de la Mama/prevención & control , Estudios Transversales , Detección Precoz del Cáncer , Femenino , Humanos
16.
Comput Math Methods Med ; 2022: 3921021, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35586674

RESUMEN

Objective: To explore the effect of moxibustion instrument combined with ultrashort wave on pain and oxidative stress in elderly patients with knee osteoarthritis (KOA). Method: 84 elderly patients with knee osteoarthritis treated in our hospital from May 2020 to June 2021 were randomly divided into observation group (n = 42) and control group (n = 42). The observation group was treated with moxibustion instrument combined with ultrashort wave, while the control group was treated with moxibustion instrument. The clinical efficacy of the two groups was compared, and the pain of the two groups was evaluated by visual analogue scale (VAS). Lysholm knee joint score scale and osteoarthritis index (WOMAC) scale of Western Ontario and McMaster University were used to evaluate the knee joint function of the two groups, and the levels of interleukin-1ß (IL-1ß), tumor necrosis factor α (TNF-α), serum superoxide dismutase (SOD), serum malondialdehyde (MDA), serum miR-155, and NLRP3 were detected in the two groups, and the comprehensive quality of life assessment questionnaire-74 was used, and the adverse reactions were compared between the two groups. Results: The total effective rate of observation group (90.48%) was higher than that of control group (69.05%) (P < 0.05). After treatment, VAS, Lysholm knee joint, WOMAC, quality of life scores, IL-1ß, TNF-α, SOD, MDA, miR-155, and NLRP3 in the observation group were better than those in the control group, and the differences were statistically significant (P < 0.05). There were no obvious adverse reactions in both groups. Conclusion. Moxibustion instrument combined with ultrashort wave can effectively improve knee joint pain, knee joint function, inflammatory reaction, oxidative stress reaction, and quality of life in elderly KOA patients, and the therapeutic effect is good.


Asunto(s)
Moxibustión , Osteoartritis de la Rodilla , Terapia por Ultrasonido , Factores de Edad , Anciano , Humanos , Articulación de la Rodilla , MicroARNs , Proteína con Dominio Pirina 3 de la Familia NLR , Osteoartritis de la Rodilla/metabolismo , Osteoartritis de la Rodilla/terapia , Estrés Oxidativo , Dolor/etiología , Manejo del Dolor , Calidad de Vida , Superóxido Dismutasa/metabolismo , Resultado del Tratamiento , Factor de Necrosis Tumoral alfa/metabolismo
17.
Neuropsychopharmacology ; 47(11): 1901-1912, 2022 10.
Artículo en Inglés | MEDLINE | ID: mdl-35396500

RESUMEN

Atypical responses to sensory stimuli are considered as a core aspect and early life marker of autism spectrum disorders (ASD). Although recent findings performed in mouse ASD genetic models report sensory deficits, these were explored exclusively during juvenile or adult period. Whether sensory dysfunctions might be present at the early life stage and rescued by therapeutic strategy are fairly uninvestigated. Here we found that under cool environment neonatal mice lacking the autism-associated gene Magel2 present pup calls hypo-reactivity and are retrieved with delay by their wild-type dam. This neonatal atypical sensory reactivity to cool stimuli was not associated with autonomic thermoregulatory alteration but with a deficit of the oxytocinergic system. Indeed, we show in control neonates that pharmacogenetic inactivation of hypothalamic oxytocin neurons mimicked atypical thermosensory reactivity found in Magel2 mutants. Furthermore, pharmacological intranasal administration of oxytocin to Magel2 neonates was able to rescue both the atypical thermosensory response and the maternal pup retrieval. This preclinical study establishes for the first-time early life impairments in thermosensory integration and suggest a therapeutic potential benefit of intranasal oxytocin treatment on neonatal atypical sensory reactivity for autism.


Asunto(s)
Trastorno Autístico , Hipoestesia , Conducta Materna , Oxitocina , Proteínas , Administración Intranasal , Factores de Edad , Animales , Antígenos de Neoplasias/genética , Antígenos de Neoplasias/metabolismo , Trastorno del Espectro Autista/complicaciones , Trastorno Autístico/complicaciones , Trastorno Autístico/genética , Trastorno Autístico/metabolismo , Fármacos del Sistema Nervioso Central/administración & dosificación , Fármacos del Sistema Nervioso Central/metabolismo , Femenino , Hipoestesia/etiología , Hipoestesia/genética , Hipoestesia/metabolismo , Hipotálamo/efectos de los fármacos , Hipotálamo/metabolismo , Conducta Materna/fisiología , Ratones , Oxitocina/administración & dosificación , Oxitocina/metabolismo , Proteínas/genética , Proteínas/metabolismo , Conducta Social
18.
PLoS One ; 17(2): e0264703, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35213672

RESUMEN

PURPOSE: To evaluate the progression of early age-related macular degeneration to neovascular age-related macular degeneration (nAMD), and identify the abnormal fundus autofluorescence (FAF) patterns and markers of choroidal neovascularization (CNV) in fellow eyes of patients with unilateral nAMD. METHODS: Sixty-six patients with unilateral nAMD who developed abnormal FAF in the fellow eyes were enrolled in this multicenter, prospective, observational study, and followed-up for 5 years. FAF images on Heidelberg Retina Angiogram Digital Angiography System (HRA) or HRA2 were classified into eight patterns based on the International Fundus Autofluorescence Classification Group system. The patients in which the fellow eyes progressed to advanced nAMD, including those who did not develop nAMD, were assessed based on the following factors: baseline FAF patterns, age, sex, visual acuity, drusen, retinal pigmentation, baseline retinal sensitivity, family history, smoking, supplement intake, hypertension, body mass index, and hematological parameters. RESULTS: Of the 66 patients, 20 dropped out of the study. Of the remaining 46 patients, 14 (30.42%, male: 9, female: 5) progressed to nAMD during the 5-year follow-up. The most common (50% eyes) FAF pattern in the fellow eyes was the patchy pattern. According to the univariate analysis, CNV development was significantly associated with age, supplement intake, and low-density lipoprotein levels (p<0.05). Multivariable analysis revealed that patients who showed non-compliance with the supplement intake were more likely to develop nAMD (p<0.05). No significant association was found between the patchy pattern and CNV development (p = 0.86). CONCLUSION: The fellow eyes (with abnormal FAF) of patients with unilateral nAMD may progress from early to advanced nAMD. However, no FAF pattern was found that predicted progression in nAMD.


Asunto(s)
Neovascularización Coroidal/etiología , Ojo/diagnóstico por imagen , Degeneración Macular/patología , Imagen Óptica , Factores de Edad , Anciano , Anciano de 80 o más Años , Suplementos Dietéticos/efectos adversos , Femenino , Estudios de Seguimiento , Humanos , Japón , Lipoproteínas LDL/sangre , Masculino , Análisis Multivariante , Estudios Prospectivos
19.
Molecules ; 27(4)2022 Feb 16.
Artículo en Inglés | MEDLINE | ID: mdl-35209127

RESUMEN

Globally, many developing countries are facing silent epidemics of nutritional deficiencies in human beings and animals. The lack of diversity in diet, i.e., cereal-based crops deficient in mineral nutrients is an additional threat to nutritional quality. The present review accounts for the significance of biofortification as a process to enhance the productivity of crops and also an agricultural solution to address the issues of nutritional security. In this endeavor, different innovative and specific biofortification approaches have been discussed for nutrient enrichment of field crops including cereals, pulses, oilseeds and fodder crops. The agronomic approach increases the micronutrient density in crops with soil and foliar application of fertilizers including amendments. The biofortification through conventional breeding approach includes the selection of efficient genotypes, practicing crossing of plants with desirable nutritional traits without sacrificing agricultural and economic productivity. However, the transgenic/biotechnological approach involves the synthesis of transgenes for micronutrient re-translocation between tissues to enhance their bioavailability. Soil microorganisms enhance nutrient content in the rhizosphere through diverse mechanisms such as synthesis, mobilization, transformations and siderophore production which accumulate more minerals in plants. Different sources of micronutrients viz. mineral solutions, chelates and nanoparticles play a pivotal role in the process of biofortification as it regulates the absorption rates and mechanisms in plants. Apart from the quality parameters, biofortification also improved the crop yield to alleviate hidden hunger thus proving to be a sustainable and cost-effective approach. Thus, this review article conveys a message for researchers about the adequate potential of biofortification to increase crop productivity and nourish the crop with additional nutrient content to provide food security and nutritional quality to humans and livestock.


Asunto(s)
Biofortificación/métodos , Productos Agrícolas/química , Micronutrientes/análisis , Factores de Edad , Agricultura , Animales , Biotecnología , Fertilizantes , Seguridad Alimentaria , Alimentos Fortificados , Salud Global , Tecnología Química Verde , Humanos , Desnutrición/epidemiología , Desnutrición/etiología , Minerales/análisis , Minerales/química , Nanotecnología , Valor Nutritivo , Fitomejoramiento , Suelo/química
20.
Yakugaku Zasshi ; 142(2): 123-128, 2022.
Artículo en Japonés | MEDLINE | ID: mdl-35110447

RESUMEN

In this study, we conducted a survey and interviews of young athletes to clarify the actual conditions of medication use and nutritional management (supplement use, etc.) with the aim of enhancing their health support. In addition, a second questionnaire was conducted for pharmacists working at medical institutions to clarify the actual situation of anti-doping (AD) activities by pharmacists, and examined the issues they face to support the health of athletes in the future. The results of the athletes' surveys revealed that the roles of pharmacists in AD activities was not recognized by athletes. In particular, the dissemination of AD education by pharmacists is considered to be critical. In future AD education, it will be necessary not only to provide knowledge of prohibited drugs, but also to provide self-medication support tailored to the individual needs of athletes, such as knowledge of nutrition and health. The results of the pharmacist survey revealed that athletes are treated by pharmacists on a daily basis, but for pharmacists, there are difficulties regarding how to provide information on AD, and it is necessary to enhance AD education at schools of pharmacy as well as in lifelong education seminars. Considering the pharmacists' AD activities as part of health support for athletes, it is considered more effective to collaborate with other health professionals such as sports doctors or nutritionists because it requires a wide range of knowledge such as nutrition.


Asunto(s)
Atletas/psicología , Atención Integral de Salud/métodos , Doping en los Deportes/prevención & control , Educación en Salud/métodos , Farmacéuticos , Rol Profesional , Sistemas de Apoyo Psicosocial , Factores de Edad , Suplementos Dietéticos , Ingestión de Alimentos , Humanos , Conocimiento , Encuestas y Cuestionarios
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