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Pak J Pharm Sci ; 33(2(Supplementary)): 839-845, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32863260

RESUMO

In the present study, we synthesized silver (Ag) nanoparticles using aqueous extracts of clove (Syzygium aromaticum) (SAE). This synthesis of green silver nanoparticles (AgNP) was a novel and effectual tool against the Newcastle Viral Disease (NDV). Syzygium aromaticum extract was used as reducing and stabilizing agent for synthesis of silver nanoparticles. AgNP were characterized using diversity of biophysical methods inclusive of Fourier transform infrared spectroscopy (FTIR), UV-VIS spectroscopy and Transmission electron microscopy (TEM) for morphology and size. Furthermore, XRD analysis confirmed the crystalline nature of the particles. In current investigations, the antiviral activity of clove buds silver nanoparticles was inspected in-vitro and in-ovo. Embryonated chicken eggs were used to perform the cytotoxicity assay of the clove extract silver nanoparticles (CESN). CESN showed in vitro antiviral activity against NDV in embryonated eggs.


Assuntos
Antivirais/farmacologia , Nanopartículas Metálicas/administração & dosagem , Extratos Vegetais/farmacologia , Prata/farmacologia , Syzygium/química , Animais , Galinhas , Química Verde/métodos , Doença de Newcastle/tratamento farmacológico , Vírus da Doença de Newcastle/efeitos dos fármacos , Espectroscopia de Infravermelho com Transformada de Fourier/métodos , Água/química
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