1.
Bioorg Med Chem Lett
; 11(17): 2291-3, 2001 Sep 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11527717
RESUMO
Six 3-substituted 3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone derivatives (3-8) were synthesized from 3-methyl DCK (2). 3-Hydroxymethyl DCK (6) exhibited potent anti-HIV activity in H9 lymphocytes with EC(50) and TI values of 1.87 x 10(-4) microM and 1.89 x 10(5), respectively. These values are similar to those of DCK and better than those of AZT in the same assay.