Efecto de un preparado lácteo con isoflavonas de la soja sobre la calidad de vida y el metabolismo óseo en mujeres posmenopáusicas: estudio aleatorizado / Effect of milk product with soy isoflavones on quality of life and bone metabolism in postmenopausal Spanish women: randomized trial

Fundamento y objetivo: Analizar los efectos de la intervención nutricional con un producto lácteo enriquecido con isoflavonas de soja sobre la calidad de vida y el metabolismo óseo en mujeres posmenopáusicas españolas. Pacientes y método: Estudio aleatorizado, controlado y doble ciego. Un total de 99 mujeres posmenopáusicas fueron distribuidas en el grupo S (n=48) con consumo de un producto lácteo enriquecido con isoflavonas de soja (50mg/día) y en el grupo C (n=51) con consumo de un producto lácteo control durante 12 meses. Se evaluaron parámetros de calidad de vida (escala Cervantes), marcadores de metabolismo óseo y masa ósea estimada mediante ultrasonografía de calcáneo (QUS).Resultados: En conjunto, hubo una mejoría en los dominios menopausia (p=0,015) y sintomatología vasomotora (p<0,001). En el grupo S destacó la valoración de la sintomatología vasomotora (p=0,001) y se diferenció positivamente respecto al grupo C en salud (p=0,019), sexo (p=0,021) y pareja (p=0,002). Se produjo un descenso de fosfatasa ácida tartrato resistente (p<0,001) y osteoprotegerina (p=0,007) y un aumento de los valores de 25-OH-vitamina D (p<0,001), sin diferencias entre grupos. En la evaluación del QUS, se observó un incremento de la densidad mineral ósea estimada en el grupo S (p=0,040), mientras que en el grupo C no se observaron diferencias significativas. Conclusiones: El consumo diario de estos productos lácteos aumenta los niveles de 25-OH-vitamina D y supone un descenso de algunos marcadores del metabolismo óseo. La suplementación adicional con isoflavonas de soja parece mejorar la calidad de vida y la masa ósea en mujeres posmenopáusicas españolas (AU)

Background and objective: To analyze the effects of nutritional intervention with a milk product enriched with soy isoflavones on quality of life and bone metabolism in postmenopausal Spanish women.Patients and method: We performed a double-blind controlled randomized trial in ninety-nine postmenopausal women. Group S women (n=48) were randomized to consume milk product enriched with soy isoflavone (50mg/day) while group C (n=51) consumed product control for 12 months. Parameters of quality of life (Cervantes scale), markers of bone metabolism and bone mass estimated by ultrasound of the calcaneus (QUS) were evaluated. Results: Overall, there was an improvement in the domains menopause (P=.015) and vasomotor symptoms (P<.001). S group emphasized the assessment of vasomotor symptoms (P=.001) and differed positively from group C in health (P=.019), sex (P=.021) and partner (P=.002). Serum levels TRAP (P<.001) and OPG (P=.007) decreased and concentrations of 25-OH-vitamin D increased (P<.001) without differences between groups. In the assessment of QUS, there was an increase in estimated bone mineral density in group S (P=.040), whereas in group C there were no significant differences. Conclusions: Daily consumption of these milk products increases levels of 25-OH-vitamin D and decreases bone metabolism markers. Additional supplementation with soy isoflavones seems to improve quality of life and bone mass in Spanish postmenopausal women

[Effect of milk product with soy isoflavones on quality of life and bone metabolism in postmenopausal Spanish women: randomized trial]. / Efecto de un preparado lácteo con isoflavonas de la soja sobre la calidad de vida y el metabolismo óseo en mujeres posmenopáusicas: estudio aleatorizado.

BACKGROUND AND OBJECTIVE: To analyze the effects of nutritional intervention with a milk product enriched with soy isoflavones on quality of life and bone metabolism in postmenopausal Spanish women. PATIENTS AND METHOD: We performed a double-blind controlled randomized trial in ninety-nine postmenopausal women. Group S women (n=48) were randomized to consume milk product enriched with soy isoflavone (50 mg/day) while group C (n=51) consumed product control for 12 months. Parameters of quality of life (Cervantes scale), markers of bone metabolism and bone mass estimated by ultrasound of the calcaneus (QUS) were evaluated. RESULTS: Overall, there was an improvement in the domains menopause (P=.015) and vasomotor symptoms (P<.001). S group emphasized the assessment of vasomotor symptoms (P=.001) and differed positively from group C in health (P=.019), sex (P=.021) and partner (P=.002). Serum levels TRAP (P<.001) and OPG (P=.007) decreased and concentrations of 25-OH-vitamin D increased (P<.001) without differences between groups. In the assessment of QUS, there was an increase in estimated bone mineral density in group S (P=.040), whereas in group C there were no significant differences. CONCLUSIONS: Daily consumption of these milk products increases levels of 25-OH-vitamin D and decreases bone metabolism markers. Additional supplementation with soy isoflavones seems to improve quality of life and bone mass in Spanish postmenopausal women.