RESUMO
We report a procedure to prepare highly monodisperse copper telluride nanocubes, nanoplates, and nanorods. The procedure is based on the reaction of a copper salt with trioctylphosphine telluride in the presence of lithium bis(trimethylsilyl)amide and oleylamine. CuTe nanocrystals display a strong near-infrared optical absorption associated with localized surface plasmon resonances. We exploit this plasmon resonance for the design of surface-enhanced Raman scattering sensors for unconventional optical probes. Furthermore, we also report here our preliminary analysis of the use of CuTe nanocrystals as cytotoxic and photothermal agents.
Assuntos
Cobre/química , Citotoxinas/química , Nanopartículas/química , Telúrio/química , Células 3T3 , Animais , Sobrevivência Celular/efeitos dos fármacos , Cobre/toxicidade , Citotoxinas/toxicidade , Hipertermia Induzida , Camundongos , Modelos Moleculares , Nanopartículas/toxicidade , Nanopartículas/ultraestrutura , Fotoquimioterapia , Análise Espectral Raman , Ressonância de Plasmônio de Superfície , Telúrio/toxicidadeRESUMO
Herein we present a direct label-free ultra-fast method for the identification and classification of the active members of a combinatorial library directly on the solid support used for their synthesis. The method is based on the appropriate functionalization of polyethylene glycol grafted polystyrene (TentaGel®) microbeads with Au@Ag nanoparticles, the use of these materials directly as solid-phase supports for the synthesis of combinatorial libraries of peptides and the subsequent SERS analysis for identification of each peptide on each bead.
Assuntos
Peptídeos/química , Técnicas de Química Combinatória , Avaliação Pré-Clínica de Medicamentos , Ouro/química , Nanopartículas Metálicas/química , Biblioteca de Peptídeos , Peptídeos/síntese química , Poliestirenos/química , Prata/química , Análise Espectral RamanRESUMO
We report on the fabrication of a novel material with the ability to remain in solution even under the very demanding conditions required for structural and dynamic characterization of biomacromolecule assays. This stability is provided by the increase in surface area of a low density material (aluminium) natively coated with a very hydrophilic surface composed of aluminium oxide (Al(2)O(3)) and metallic silver nanoparticles. Additionally, due to the dense collection of active hot spots on their surface, this material offers higher levels of SERS intensity as compared with the same free and aggregated silver nanoparticles.