[Effect of docanol on the status of hemostasis and fibrinolysis systems, as well as lipid spectrum in patients with ischemic heart disease depending on the initial level of fibrinolytic activity]. / Vliianie dokanola na sostoianie sistem gemostaza, fibrinoliza i lipidnyi spektr u bol'nykh ishemicheskoi bolezn'iu serdtsa v zavisimosti ot iskhodnogo urovnia fibrinoliticheskoi aktivnosti.

Forty patients with coronary heart disease (CHD) concurrent with hyperlipidemia were divided into 2 groups according to the baseline fibrinolytic activity. The group with the depressed fibrinolytic system displayed the highest atherogenicity index and levels of cholesterol, low and very low density lipoprotein cholesterol and half levels of high density lipoproteins. After 45-day ingestion of docanol, a new Russian food additive containing docosahexanoic and eicosapentaenoic acids there were positive changes in the lipid spectrum in the both groups. The fibrinolytic changes were heterodirectional: activator and plasma activities increased in the group of fibrinolytic depression while in the group of baseline normal fibrinolysis the activity of plasminogen activator fell.

[Fibrinolytic and thrombolytic properties of a plasminogen activator isolated from the culture broth of calf kidney cells]. / Fibrinoliticheskie i tromboliticheskie svoistva aktivatora plazminogena, vydelennogo iz kul'tural'noi zhidkosti kletok pochki teliat.

Plasminogen activator isolated from cultural liquid of calf renal cells is an enzyme having a fibrinolytic action in vitro and in vivo, provoking a demonstrable thrombolytic effect, which depends on the drug dose, thrombus size and animal's body weight.

[Plasminogen activator from a kidney cell culture]. / Aktivator plazminogena iz kul'tury kletok pochki.

Plasminogen activator (PA) isolated from kidney's cells culture (doses 10 to 5000 IE/kg) induced lysis of experimental thrombi. Lysis time decreased from 214 to 23 min after PA infusion in doses 10 to 700 IE/kg, further doses decrease from 700 to 5000IE/kg does not accelerate lysis time of thrombi. PA infusion in doses mentioned increases the activator activity of plasma and euglobulin lysis time, but does not change the fibrinolytic activity, antiplasmin content and fibrinogen concentration.