1.
Biochim Biophys Acta
; 1371(1): 11-6, 1998 Apr 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-9565651
RESUMO
The ribosome inactivating plant proteins (RIPs) ricin and viscumin but not Ricinus communis agglutinin are able induce vesicle-vesicle fusion. A model is suggested in which the toxicity of the RIPs is partially determined by their fusogenicity. Herein, fusion is hypothesized to allow the RIPs to leak across endocytic vesicles to approve their access to cytoplasmic ribosomes.