Selenium status in a group of schoolchildren from the region of Madrid, Spain.

BACKGROUND: To assess the selenium status of a group of schoolchildren from the Region of Madrid, Spain. METHODS: Study subjects comprised 483 children (216 boys and 267 girls) aged between 8 and 13 years. Selenium intake was determined using a 3-day food record. The foods consumed were transformed into energy and nutrients, and the selenium intake was compared with that recommended. Serum selenium levels were also recorded. RESULTS: Mean (SD) selenium intake [91.0 (25.2) µg day(-1) ] was above the recommended level in 99.4% of subjects; the main dietary sources were cereals, meats, fish and milk products. The serum selenium concentration [mean (SD) 71.1 (14.4) µg L(-1) ], however, was <60 µg L(-1) in 13.9% of subjects, and <45 µg L(-1) in 5.6%. The serum selenium concentration correlated with the selenium intake (r = 0.169; P < 0.05). Children with a serum selenium concentration of <75 µg L(-1) had significantly smaller selenium intakes than those with a serum concentration of ≥75 µg L(-1) . CONCLUSIONS: Although selenium intake was generally above that recommended, the serum selenium concentration of the children could be improved. This could be achieved by increasing the relative consumption of cereals and other selenium rich foods such as fish.

Comparative study of anthocyanin and volatile compounds content of four varieties of Mexican roselle (Hibiscus sabdariffa L.) by multivariable analysis.

Anthocyanins are a group of water-soluble pigments that provide red, purple or blue color to the leaves, flowers, and fruits. In addition, benefits have been attributed to hypertension and cardiovascular diseases. This study compared the content of total anthocyanins and volatile compounds in aqueous and ethanolic extracts of four varieties of Mexican roselle, with different levels of pigmentation. The multivariable analysis of categorical data demonstrated that ethanol was the best solvent for the extraction of both anthocyanins and volatile compounds. The concentration of anthocyanin in pigmented varieties ranged from 17.3 to 32.2 mg of cyanidin 3-glucoside/g dry weight, while volatile compounds analysis showed that geraniol was the main compound in extracts from the four varieties. The principal component analysis (PCA) allowed description of results with 77.38% of variance establishing a clear grouping for each variety in addition to similarities among some of these varieties. These results were validated by the confusion matrix obtained in the classification by the factorial discriminate analysis (FDA); it can be useful for roselle varieties classification. Small differences in anthocyanin and volatile compounds content could be detected, and it may be of interest for the food industry in order to classify a new individual into one of several groups using different variables at once.

Identificación intraoperatoria del área motora suplementaria en cirugía neurooncológica / Intraoperative identification of the supplementary

Objetivos. El objetivo principal del estudio es conseguirla identificación intraoperatoria de la función delárea motora suplementaria (AMS) implicada en tareasmotoras complejas. El objetivo secundario es valorar elpronóstico funcional tras la preservación quirúrgica deeste área.Método. Se han seleccionado 15 pacientes con tumorescerebrales localizados en área premotora. Todoslos pacientes fueron intervenidos despiertos. El córtexmotor primario fue identificado mediante estimulacióncerebral directa. Para identificar el AMS, el pacienterealizó una tarea motora de oposición de dedos conla mano contralateral a la lesión que se bloqueabamediante la estimulación eléctrica del córtex cerebralpremotor.Resultados. El AMS pudo ser identificada en todoslos pacientes mediante este método.La resección fue macroscópicamente completa en 13pacientes (86.6%) y subtotal en 2 (13.3%). La funciónencontrada en el AMS se ha podido preservar en 14pacientes (93,3%) (..) (AU)

Objectives. The main objective of the present workwas to identify, by means of intraoperative electricalstimulation, the supplementary motor area (SMA)region which is implicated in complex motor function.The functional prognostic relevance of the surgical preservationof this area was also analyzed.Method. Fifteen patients with tumors infiltrating thepremotor cortex were selected. All patients were operatedunder awake conditions. Primary motor cortexwas identified with intraoperative electrical stimulation(IES). To identify the SMA, patients were askedto do a finger opposition motor task with their handcontralateral to the lesion, that was blocked by electricallystimulating the premotor cerebral cortex.Results. SMA was identified in all patients with (..) (AU)

Vitamin D status in a group of Spanish schoolchildren.

AIM: The aim was to determine the vitamin D status of a group of Spanish schoolchildren in order to help in the design of campaigns to prevent vitamin D deficiency in this subpopulation. METHODS: This was a cross-sectional observational study, carried out in schools in Madrid (Spain), during 2007-2008. The study enrolled 102 schoolchildren (aged 9-13 years). Vitamin D intake was monitored using a three-day food record. All foods consumed were converted into energy and nutrients and the vitamin D intake compared to that recommended. The children's serum 25-OH-cholecalciferol (25[OH]D) concentrations were also recorded. RESULTS: Vitamin D intake (2.83±3.27 mg/day) was below that recommended in 86.9% of the children, and the serum 25(OH)D concentration (49.6±15.9 nmol/L) below 50 nmol/L (moderate deficit) in 51% of the children; in 8% it was below 30 nmol/L (severe deficit). The children who showed a coverage of at least 67% of the recommended intake of vitamin D (Group HD) consumed more dairy products, fish, fruit and vegetables than those whose intakes covered <67% of the recommended intake (Group LD). The HD children had higher serum 25(OH)D concentrations than the LD children; in addition, fewer cases of deficit were seen among them. CONCLUSION: The vitamin D status of the studied children was likely to improve, and could be ameliorated via a relatively increased consumption of dairy products, fish, cereals, fruits and vegetables, by including foods fortified in vitamin D if necessary, and by increased ­ but safe ­ exposure to the sun.

[Body weight perception and dieting behaviour in Spanish population]. / Percepción del peso corporal y medidas adoptadas para su control en población española.

INTRODUCTION: A high percentage of the population initiate or keep diets to lose weight independently of suffering or not overweight/obesity. Nevertheless, exists a great unknowledge on the more convenient guidelines to achieve this aim. OBJECTIVE: To analyze weight perception and types of behavior to control the corporal weight in Spanish adults in order to be able to start the campaigns most adapted to provide a correct nutritional information to the population. METHODS: 2,168 subjects (18 +/- 50 years) of 5 Spanish provinces were studied. Anthropometric and information about the worry about corporal weight data was obtained. RESULTS: 65.6% of subjects declare a desire to lose weight and 44.9% have followed diets with this purpose in some moment (especially in female population). 63.9% of subjects increase physical activity to control weight, 23.9% consumes dietetic products or medicinal herbs and 48.0% compensate the excesses when they try to lose weight. Sweets (24.5%), fats (15.4%), pastries (11.4%) and bread (11.4%) are avoided and fruits and vegetables consumption is increased (specially by women) when try to lose weight. CONCLUSIONS: Weight loss practices use to be inadequate due to the desire to lose weight quickly and to the unknowledge about the most adecuate diet to achieve this aim. It is necessary to avoid this type of practices and to improve the knowledge on nutrition in the population.

Percepción del peso corporal y medidas adoptadas para su control en población española / Body weight perception and dieting behaviour in Spanish population

Introducción: Existe un elevado porcentaje de personas que padeciendo o no sobrepeso/obesidad, inician o mantienen dietas encaminadas a conseguir un adelgazamiento. Sin embargo, existe un gran desconocimiento sobre las pautas que resultan más convenientes para conseguir este objetivo. Objetivos: Analizar la percepción del peso y los tipos de comportamiento realizados para controlar el peso corporal en adultos españoles con el fin de poder poner en marcha las campañas más adecuadas para proporcionar a la población una correcta información nutricional. Métodos: Se estudió a 2.168 sujetos (18-50 años) de 5 provincias españolas. Se recogieron datos antropométricos e información sobre la preocupación por el peso corporal. Resultados: un 65,6% de la población desea perder peso y un 44,9% ha seguido dietas con este fin en algún momento, siendo mayor en el caso de las mujeres. Cuando se intenta controlar el peso un 63,9% de la población aumenta su actividad física, un 23,9% toma productos dietéticos o plantas medicinales y un 48,0% compensa los excesos. Además se evita el consumo de alimentos como los dulces (24,5%), la grasa (15,4%), los bollos (11,4%) o el pan (11,4%) y, sobre todo en población femenina, se aumenta el consumo de frutas y verduras. Conclusiones: Las medidas adoptadas para perder peso suelen ser poco adecuadas debido al deseo de adelgazar a toda costa y a la falta de conocimientos sobre cual es la dieta más adecuada para este fin. Es necesario evitar este tipo de prácticas y mejorar los conocimientos de la población en materia de nutrición (AU)

Introduction: A high percentage of the population initiate or keep diets to lose weight independently of suffering or not overweight/obesity. Nevertheless, exists a great unknowledge on the more convenient guidelines to achieve this aim. Objective: To analyze weight perception and types of behavior to control the corporal weight in Spanish adults in order to be able to start the campaigns most adapted to provide a correct nutritional information to the population. Methods: 2,168 subjects (18 ± 50 years) of 5 Spanish provinces were studied. Anthropometric and information about the worry about corporal weight data was obtained. Results: 65.6% of subjects declare a desire to lose weight and 44.9% have followed diets with this purpose in some moment (especially in female population). 63.9% of subjects increase physical activity to control weight, 23.9% consumes dietetic products or medicinal herbs and 48.0% compensate the excesses when they try to lose weight. Sweets (24.5%), fats (15.4%), pastries (11.4%) and bread (11.4%) are avoided and fruits and vegetables consumption is increased (specially by women) when try to lose weight. Conclusions: Weight loss practices use to be inadequate due to the desire to lose weight quickly and to the unknowledge about the most adecuate diet to achieve this aim. It is necessary to avoid this type of practices and to improve the knowledge on nutrition in the population (AU)

Toxicodermia por Rhizoma coptidis / Toxicoderma due to Rhizoma coptidis

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Changes in folate status in overweight/obese women following two different weight control programmes based on an increased consumption of vegetables or fortified breakfast cereals.

The modification of folate status was analysed in a group of sixty-seven overweight/obese women of childbearing age (20-35 years). Subjects were randomly assigned to one of two slightly hypocaloric diets: diet V (increased consumption of vegetables) or diet C (increased consumption of breakfast cereals). Dietetic, anthropometric and biochemical data were collected at the start of the study and again at 2 and 6 weeks. At 6 weeks a weight loss of 2.0 (sd 1.3) kg was achieved in V subjects and of 2.8 (sd 1.4) kg in C subjects (P < 0.05). At the start of the study, 64.2 % of all subjects had a folate intake of < 67 % of the recommended intake; this fell to just 3 % (7.14 % of V subjects and 0 % of C subjects) by week 6. Significant increases were only seen in C subjects in serum folate concentrations (both at 2 and 6 weeks), accompanied by a significant reduction in serum homocysteine (at week 6). Some 62.1 % of all subjects had serum folate concentrations of > or = 13.6 nmol/l (associated with a very low risk of neural tube defects) at the start of the study, while 87.0 % (85.2 % of V subjects and 88.9 % of C subjects) had concentrations of > or = 13.6 nmol/l at 6 weeks (P < 0.01). Increasing the relative consumption of vegetables/cereals in the context of a slightly hypocaloric diet may therefore be a good way to lose body weight. Breakfast cereals may be of special help with respect to folate status and serum homocysteine levels in overweight/obese young women following energy restriction diets.

Abnormalities in the bone mineral metabolism in HIV-infected patients.

OBJECTIVE: To evaluate bone mineral metabolism in HIV infected and asymptomatic patients receiving highly active antiretroviral therapy (HAART) containing protease inhibitors (PI) and naïve patients. METHODS: We studied 30 asymptomatic HIV infected male patients, 13 in the naive group and 17 in the IP group, both without differences in demographics characteristics. We excluded women and patients with any known factor associated to osteopenia. We did a nutritional questionnaire, a DEXA scan in lumbar spine and femur, a study of CD4 lymphocytes, viral load and an analysis of bone formation and resorption markers in all patients. We compared vitamin D and PTH levels with a control group of healthy male volunteers age-pareated. For the statistical analysis we used the SPSS program. RESULTS: Osteopenia was present in 17/30 (57%), 8/13 (61.5%) in the naïve group and 9/17 (53%) in the PI group (not significant differences). We found a vitamin D deficiency in 86% of patients, with mean serum levels that was found to be significantly lower than those from a healthy control group (p=0.04). Testosterone level was significantly related to bone mineral density in lumbar spine (p

Anestesia con crema EMLA: una aplicación interesante en cirugía plástica / Anesthesia con EMLA cream: a promising application for plastic surgery

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Effects of oral phosphorus supplementation on mineral metabolism of renal transplant recipients.

BACKGROUND: Persistent hyperparathyroidism (HPT) is frequently observed in kidney transplant recipients. Hypophosphataemia is a common biochemical consequence of HPT. Theoretically, oral phosphorus administration may induce negative effects on the control of HPT, though this point has never been demonstrated in kidney-transplant recipients. This study was designed to evaluate the effects of oral phosphorus supplementation on the mineral metabolism of successful kidney transplant recipients. METHODS: Thirty-two kidney transplant recipients with serum creatinine < 2 mg/dl and serum phosphate levels <3.5 mg/dl were included in the study. After a washout period in which oral phosphorus supplementation was discontinued, the following parameters were determined (F0 period): serum calcium, phosphate, alkaline phosphatase, uric acid, bicarbonate, PTH, 1,25-dihydroxyvitamin D3 (1,25 (OH)(2)D) and 25-hydroxyvitamin D3 (25OHD). Creatinine clearance, calcium, and phosphate excretion were determined from a 24-h urine sample. The same determinations were repeated (F1 period) after all patients received 1.5 g of oral phosphorus for 15 days. For data analysis, patients were divided into two subgroups (optimal and suboptimal) according to allograft function (Ccr>or < 70 ml/min/1.73 m2). RESULTS: In the F0 period, only nine of 32 patients had PTH levels within the normal range (<65 pg/ml). The mean concentrations of PTH, 1,25(OH)(2)D and 25OHD were 132+/-97pg/ml, 40.5+16pg/ml and 12.5+/-8.2 ng/ml respectively. Phosphorus supplementation led to significant reductions in serum calcium and 1,25(OH)(2)D concentrations, as well as in urinary calcium excretion in the whole group. On the contrary, serum phosphate, PTH, and urinary phosphate excretion increased significantly. The percentage increase in PTH concentrations after phosphorus supplementation were similar in patients with optimal and suboptimal allograft function (33 vs 36%). The reduction of 1,25 (OH)(2)D concentrations after phosphorus supplementation was observed mainly in the subgroup with optimal allograft function (21% reduction with respect to baseline values), while the mean 1,25(OH)(2)D concentrations in patients with suboptimal allograft function scarcely changed (1.4% increase). Changes in 1,25(OH)(2)D concentrations after phosphorus supplementation, expressed as a percentage of the initial concentrations, correlated positively with the percentage changes in PTH concentrations for the whole group, as well as for each subgroup. The best determinants for the percentage and the absolute increase in PTH concentration after phosphorus supplementation was the final serum phosphate concentration (F=4.84, r=0.37, P=0.035) and the increase in serum phosphate (F=7.69, r=0.45, P= 0.009) respectively. CONCLUSIONS: Oral phosphorus supplementation led to a significant increase in the PTH concentration of kidney transplant recipients. The mean 1,25(OH)(2)D concentration decreased mainly in recipients with optimal allograft function. The counterbalance effect of PTH on 1,25(OH)(2)D production may account for the relative preservation of 1,25(OH)2D levels in recipients with suboptimal allograft function.

Effect of the mode of calcitriol administration on PTH-ionized calcium relationship in uraemic patients with secondary hyperparathyroidism.

To assess the effect of the different modes of calcitriol administration on PTH-ionized calcium relationship we conducted a prospective clinical trial in 33 patients on chronic haemodialysis with secondary hyperparathyroidism (four times upper normal limit intact PTH) who were randomly assigned, with stratification to PTH levels, to receive daily oral, intermittent oral, or intermittent intravenous calcitriol at the same dose of 0.045 micrograms/kg/weekly. PTH-iCa curves were generated by inducing hypo- or hypercalcaemia in sequential haemodialysis 1 week apart, before and after 10 weeks on treatment. All patients were dialysed against a dialysate calcium concentration of 2.5 mEq/l throughout the study period. After drop-outs, 26 patients completed the study: 11 on intravenous calcitriol (mean basal PTH +/- SD: 666 +/- 280 pg/ml), eight on intermittent oral calcitriol (mean basal PTH: 831 +/- 361), and seven on daily oral calcitriol (mean basal PTH: 719 +/- 280). Serum ionized calcium and phosphorus significantly increased in intravenous and daily oral groups after calcitriol treatment, but not in the intermittent oral group. Basal PTH did not significantly change in the three groups after 10 weeks on treatment. Maximal PTH significantly decreased in intravenous group (1449 +/- 660 versus 1122 +/- 691 pg/ml, P = 0.0085) and at the limit of statistical significance in the intermittent oral group (1701 +/- 774 versus 1445 +/- 634, P = 0.12), but it did not change in the daily oral group. Minimal PTH did not modify in the three groups. In all three groups, a shift to the right in the PTH-iCa relationships were observed, with significant changes in the set point of calcium.(ABSTRACT TRUNCATED AT 250 WORDS)