RESUMO
The cardioprotective effects of Ganoderma lucidum extract were examined in experiments with global ischemia (45 min) and reperfusion (30 min) of isolated and perfused rat heart. The course of preventive administration of the extract in a dose of 400 mg/kg for 15 days diminished necrotic death of cardiomyocytes and reduced reperfusion contracture. Ganoderma lucidum extract demonstrated antioxidant properties. The authors believe that the cardioprotective properties of Ganoderma lucidum extract are largely determined by its antioxidant properties.
Assuntos
Extratos Vegetais/química , Extratos Vegetais/farmacologia , Reishi/química , Animais , Antioxidantes/química , Antioxidantes/farmacologia , Antioxidantes/uso terapêutico , Sequestradores de Radicais Livres/metabolismo , Coração/efeitos dos fármacos , Masculino , Traumatismo por Reperfusão Miocárdica/tratamento farmacológico , Miócitos Cardíacos/citologia , Miócitos Cardíacos/efeitos dos fármacos , Extratos Vegetais/uso terapêutico , Ratos , Ratos WistarRESUMO
Nettle extract produced from leaves crushed to 40-70 nm fragments protects the stomach mucous membrane, and does it better than the extract derived from same leaves crushed to 1 mm fragments, on the models of peptic ulcers caused by acetylsalicylic acid, histamine, prednisolone, and immobilized stress. The antiulcer activity of the nettle extract from 40-70 nm fragments is comparable with the effect of buckthorn oil. Nettle extracts also hinder the excess acid secretion and diminish the acidity of stomach juice in experimental peptic ulcer caused by pylorus ligation.
Assuntos
Extratos Vegetais/uso terapêutico , Úlcera Gástrica/tratamento farmacológico , Urtica dioica/química , Animais , Suco Gástrico/metabolismo , Mucosa Gástrica/efeitos dos fármacos , Mucosa Gástrica/patologia , Mucosa Gástrica/fisiopatologia , Hippophae/química , Masculino , Fitoterapia , Folhas de Planta/química , Óleos de Plantas/uso terapêutico , Ratos , Úlcera Gástrica/patologiaRESUMO
A course of treatment (16 mg/kg orally during 5 days) by Aralia mandshurica or Rhodiola rosea extracts reduced the incidence of ischemic and reperfusion ventricular arrhythmias during 10-min ischemia and 10-min reperfusion. Extracts of Eleutherococcus senticosus, Leuzea carthamoides, and Panax ginseng did not change the incidence of ischemic and reperfusion arrhythmias. Chronic treatment by aralia, rhodiola, and eleutherococcus elevated the ventricular fibrillation threshold in rats with postinfarction cardiosclerosis. Ginseng and leuzea did not change this parameter in rats with postinfarction cardiosclerosis.
Assuntos
Antiarrítmicos/uso terapêutico , Arritmias Cardíacas/tratamento farmacológico , Traumatismo por Reperfusão Miocárdica/tratamento farmacológico , Extratos Vegetais/uso terapêutico , Animais , Antiarrítmicos/química , Aralia/química , Eleutherococcus/química , Leuzea/química , Panax/química , Extratos Vegetais/química , Ratos , Ratos Wistar , Rhodiola/química , Fibrilação Ventricular/tratamento farmacológicoRESUMO
The course administration (16 mg/kg per os for 5 days) of extracts of Panax ginseng or Rhodiola rosea induced a decrease in the infarction size/the area at risk (IS AAR) ratio during a 45-min local ischemia and a 2-hr reperfusion in artificially ventilated chloralose-anaesthetized rats. Single administration of ginseng or Rhodiola 24 h before ischemia did not affect the IS/AAR ratio. Chronic administration of Extracts of Eleutherococcus senticosus, Leuzea carthamoides and Aralia mandshurica had no effect on the IS/AAR ratio. Pretreatment with extract ofAralia mandshurica prevented appearance of ventricular arrhythmias during first 10 min coronary artery occlusion. Pretreatment with extract of Rhodiola rosea decreased the incidence of ventricular fibrillation during ischemia. Single administration of extracts of Panax ginseng or Rhodiola rosea in a dose of 16 mg/kg had no effect on the IS/AAR ratio. The authors conclude that extracts of ginseng or Rhodiola exhibit a powerful cardioprotective effect. Extract of Aralia exhibit a strong antiarrhythmic effect. Extracts of ginseng and Rhodiola do not mimic phenomena of ischemia preconditioning.
Assuntos
Antiarrítmicos/farmacologia , Cardiotônicos/farmacologia , Contração Miocárdica/fisiologia , Infarto do Miocárdio/tratamento farmacológico , Extratos Vegetais/farmacologia , Animais , Antiarrítmicos/uso terapêutico , Aralia/química , Arritmias Cardíacas/tratamento farmacológico , Arritmias Cardíacas/fisiopatologia , Cardiotônicos/uso terapêutico , Eleutherococcus/química , Precondicionamento Isquêmico Miocárdico , Leuzea/química , Contração Miocárdica/efeitos dos fármacos , Infarto do Miocárdio/fisiopatologia , Panax , Fitoterapia , Extratos Vegetais/uso terapêutico , Ratos , Ratos Wistar , RhodiolaRESUMO
We have studied the new complex plant adaptogen preparation tonizid containing dry extracts of Aralia mandshurica, Panax ginseng, Rhodiola rosea, and Eleutherococcus senticosus. The course administration (5 days) of tonizid led to a decrease in the ratio of necrotic zone size/risk area during a 45-min local ischemia and a 2-hr reperfusion in artificially ventilated chloralose anaesthetized rats. This compound decreased the necrotic zone but did not change the size of the risk area. Tonizid also prevented an appearance of ventricular fibrillation during a 45-min coronary artery occlusion, but did not affect the incidence of ventricular arrhythmias during a brief ischemia and reperfusion. In a separate series of experiments, tonizid was administered during 5 days to rats with postinfarction cardiac sclerosis, which was formed 45 days after coronary artery occlusion. In this case, tonizid dose-dependently elevated the ventricular fibrillation threshold. The experiments in vitro were performed on a model of 35-min total ischemia and 30-min reperfusion of isolated rat heart using the Langendorff technique. The course administration of tonizid attenuated the reperfusion-induced decrease in the left ventricular pressure and the rate of contraction. However, tonizid did not prevent a reperfusion-induced reduction in the heart rate, a decrease in the rate of relaxation, and an increase in the final diastolic pressure. Tonizid decreased the creatine kinase levels in the venous effluent from isolated rat heart during reperfusion. At the same time, the plant adaptogen did not affect the incidence of ventricular arrhythmias and coronary flow. It is suggested that tonizid can be used as an adaptogen drug attenuating the contractility dysfunction and preventing an appearance of irreversible cardiomyocyte damage during ischemia and reperfusion. Tonizid exhibits cardioprotective and antifibrillatory properties during acute cardiac ischemia/reperfusion and postinfarction cardiac fibrosis.
Assuntos
Antiarrítmicos/uso terapêutico , Cardiotônicos/uso terapêutico , Contração Miocárdica/efeitos dos fármacos , Traumatismo por Reperfusão Miocárdica/prevenção & controle , Extratos Vegetais/uso terapêutico , Animais , Coração , Frequência Cardíaca/efeitos dos fármacos , Técnicas In Vitro , Traumatismo por Reperfusão Miocárdica/fisiopatologia , Miocárdio/patologia , Ratos , Ratos Wistar , Esclerose , Fibrilação Ventricular/prevenção & controleRESUMO
We used a model of total 45-min ischemia and 30-min reperfusion of isolated rat heart by the Langendorf technique. The course administration (15 days) of Gonoderma lucidum extract attenuated reperfusion contracture and decreased creatine kinase levels in the venous effluent from rat isolated heart during reperfusion. However, the extract did not prevent a reperfusion decrease in pressure developed by the left ventricle, reduction in the heart rate, contraction and relaxation rates. The extract had no effect on the incidence of ventricular arrhythmia. We believe that Ganoderma lucidum extract is a drug which attenuates diastolic dysfunction and prevents irreversible cardiomyocyte damage during ischemia and heart reperfusion.
Assuntos
Cardiotônicos/farmacologia , Diástole/efeitos dos fármacos , Medicamentos de Ervas Chinesas/farmacologia , Traumatismo por Reperfusão Miocárdica/prevenção & controle , Miócitos Cardíacos/efeitos dos fármacos , Reishi/química , Animais , Cardiotônicos/administração & dosagem , Cardiotônicos/uso terapêutico , Medicamentos de Ervas Chinesas/administração & dosagem , Medicamentos de Ervas Chinesas/uso terapêutico , Técnicas In Vitro , Masculino , Traumatismo por Reperfusão Miocárdica/patologia , Miócitos Cardíacos/patologia , Necrose , Ratos , Ratos WistarRESUMO
A course administration of the complex plant adaptogenic drug tonizid was ascertained to increase murine exercise tolerance. In addition, the drug increased murine survival during hypobaric hypoxia (at an altitude of 10,500 m upon 20-min exposure). A model of total 35-min ischemia and that of 30-min reperfusion of the rat isolated heart were used by the Langendorff technique. The course administration of tonizid attenuated a reperfusion decrease in the left ventricular pressure and in the rate of contraction. However, tonizid did not prevent a reperfusion reduction in heart rate, a decrease in the rate of relaxation and an elevation of end diastolic pressure. Tonizid lowered the level of creatine kinase in the venous effluent from the isolated rat heart during reperfusion. At the same time, the plant adaptogen exerted no effect on the incidence of ventricular arrhythmias and coronary flow. It has been suggested that tonizid is an adaptogenic drug that attenuates contractile dysfunction and prevents irreversible cardiomyocytic damage during ischemia and reperfusion of the isolated heart.
Assuntos
Contração Miocárdica/efeitos dos fármacos , Isquemia Miocárdica/tratamento farmacológico , Traumatismo por Reperfusão Miocárdica/prevenção & controle , Miócitos Cardíacos/patologia , Extratos Vegetais/farmacologia , Adaptação Fisiológica , Animais , Pressão Sanguínea/efeitos dos fármacos , ATPases Transportadoras de Cálcio/efeitos dos fármacos , ATPases Transportadoras de Cálcio/metabolismo , Cardiotônicos/farmacologia , Avaliação Pré-Clínica de Medicamentos/métodos , Frequência Cardíaca/efeitos dos fármacos , Técnicas In Vitro , Masculino , Camundongos , Isquemia Miocárdica/patologia , Miócitos Cardíacos/efeitos dos fármacos , Piracetam/farmacologia , Ratos , Ratos WistarRESUMO
The course of treatment with combined adaptogenic plant preparation Tonizid improved mouse survival under conditions of hypobaric hypoxia and reduced the necrotic zone/risk zone ratio during ischemia and reperfusion in rats under conditions of artificial ventilation. The test preparation decreased the size of the necrotic zone, but had no effect on the size of the risk zone. Tonizid prevented ventricular fibrillation during coronary occlusion and exhibited antihypoxic, cardioprotective, and antifibrillation properties.
Assuntos
Antiarrítmicos/uso terapêutico , Cardiotônicos/uso terapêutico , Hipóxia/tratamento farmacológico , Miocárdio/patologia , Fitoterapia/métodos , Preparações de Plantas/uso terapêutico , Traumatismo por Reperfusão/tratamento farmacológico , Rhodiola/química , Animais , Antiarrítmicos/farmacologia , Cardiotônicos/farmacologia , Masculino , Camundongos , Necrose/tratamento farmacológico , Preparações de Plantas/farmacologiaRESUMO
Maxar and legalon--hepatoprotectors containing polyphenols--exhibit a therapeutic effect with respect to the experimental Reye's syndrome induced in rats by intraperitoneal injections of 4-pentenoic acid. Maxar restores the activity of enzymes of the hepatic origin, normalizes the content of bilirubin, glucose, phenols, and malonic aldehyde in the blood serum, stimulates the production of ketone bodies and ammonia detoxication, and improves the histologic structures of liver and cortex. Legalon also decreases the structural-metabolic disorders accompanying the Reye's syndrome, but to as lower ewxtent.