RESUMO
No disponible
Assuntos
Humanos , Doenças do Nervo Óptico/epidemiologia , Doenças do Nervo Óptico/prevenção & controle , DNA Mitocondrial/genética , Fitoestrógenos/uso terapêutico , Terapia Genética , Benzoquinonas/uso terapêutico , Células Ganglionares da Retina , Células Ganglionares da Retina/patologia , Qualidade de VidaRESUMO
OBJECTIVE: To ascertain the efficacy of idebenone and multivitamin treatment in Leber's hereditary optic neuropathy (LHON). METHOD: Two patients diagnosed of unilateral LHON were treated with megadoses of idebenone, vitamin C and riboflavin for one year. They were examined clinically before, during and after treatment. RESULTS: No improvement of visual function was observed. Despite the idebenone treatment, in both cases the second eye became involved. CONCLUSIONS: Despite previous reports of visual recovery with idebenone in patients with LHON, our experience shows that an effective treatment for Leber's disease remains to be found.
Assuntos
Antioxidantes/uso terapêutico , Ácido Ascórbico/uso terapêutico , Benzoquinonas/uso terapêutico , Atrofia Óptica Hereditária de Leber/tratamento farmacológico , Riboflavina/uso terapêutico , Complexo Vitamínico B/uso terapêutico , Vitaminas/uso terapêutico , Adulto , Feminino , Humanos , Masculino , Falha de Tratamento , Ubiquinona/análogos & derivadosRESUMO
Objetivo: Determinar la eficacia del tratamiento con idebenona y multivitamínico en la neuropatía óptica hereditaria de Leber (NOHL). Método: Dos pacientes diagnosticados de NOHL, fueron tratados con idebenona, vitamina C y riboflavina durante un año. Ambos fueron evaluados clínicamente antes, durante y después del tratamiento. Resultado: Ninguno de los dos pacientes experimentó mejoría visual y ambos sufrieron afectación en el segundo ojo. Conclusiones: A pesar de casos publicados en la literatura de recuperación visual con idebenona en pacientes con NOHL, nuestra experiencia indica que este tratamiento no es efectivo para la enfermedad de Leber
Objective: To ascertain the efficacy of idebenone and multivitamin treatment in Lebers hereditary optic neuropathy (LHON). Method: Two patients diagnosed of unilateral LHON were treated with megadoses of idebenone, vitamin C and riboflavin for one year. They were examined clinically before, during and after treatment. Results: No improvement of visual function was observed. Despite the idebenone treatment, in both cases the second eye became involved. Conclusions: Despite previous reports of visual recovery with idebenone in patients with LHON, our experience shows that an effective treatment for Lebers disease remains to be found