RESUMO
Iron, zinc and vitamin A status was assessed in 309 plantation workers during pregnancy and in a sub-sample of 108 subjects at 20 to 36 weeks postpartum and the birth weights of their newborn were noted. A significant positive correlation was noted between haemoglobin concentration at 10-26 weeks of gestation of anaemic mothers (n = 180) and birth weights of their new born. Depleted iron stores (serum ferritin < 12 micrograms/l) were noted in 33.3% of subjects at 10-26 weeks of gestation. There was no significant change in serum ferritin concentration at > 32 weeks of gestation. Iron deficiency persisted at 20-36 weeks postpartum. Marginal vitamin A deficiency was also noted, as, 46.2% and 15.6% of the subjects respectively, had low serum vitamin A levels in pregnancy and postpartum. Low serum zinc levels were noted only in pregnancy. Iron supplementation during pregnancy was only effective in preventing further deterioration in iron status and it should be continued for about 12 weeks after delivery.
Assuntos
Agricultura , Micronutrientes , Estado Nutricional , Saúde Ocupacional , Período Pós-Parto , Gravidez , Adolescente , Adulto , Feminino , Humanos , Ferro/sangue , Sri Lanka , Vitamina A/sangue , Zinco/sangueRESUMO
Intervention measures against anemia available to plantation workers during pregnancy include fortified food supplements (thriposha) and iron-folate supplements containing 60 mg elemental Fe. The effectiveness of these intervention measures was studied in 195 subjects whose iron and nutritional status were assessed at < 24 and > 32 wk of gestation. Taking thriposha conferred no significant benefit on maternal nutritional status, probably because sufficient amounts were not consumed. An increase in the duration of iron-folate supplementation to > 17 wk caused a significant positive change (P < 0.01) in hemoglobin, whereas an increase in the dose frequency had no significant benefit. Anthelminthic therapy in addition to iron-folate supplements caused a significant positive change in hemoglobin (P < 0.001) and serum ferritin (P < 0.005) compared with no supplementation. Thus, anthelminthic therapy significantly increased the beneficial effects of iron supplementation on hemoglobin concentration and iron status.
Assuntos
Anemia/prevenção & controle , Anti-Helmínticos/uso terapêutico , Ácido Fólico/uso terapêutico , Ferro/uso terapêutico , Complicações na Gravidez/prevenção & controle , Adolescente , Adulto , Anemia/etiologia , Índice de Massa Corporal , Combinação de Medicamentos , Quimioterapia Combinada , Feminino , Ácido Fólico/administração & dosagem , Ácido Fólico/efeitos adversos , Seguimentos , Alimentos Fortificados , Hemoglobinas/análise , Humanos , Ferro/administração & dosagem , Ferro/efeitos adversos , Estado Nutricional , Gravidez , Complicações na Gravidez/etiologia , Complicações Parasitárias na Gravidez/tratamento farmacológico , Protoporfirinas/sangue , Sri LankaRESUMO
The administration of large doses of corticosterone to normal adult male rats resulted in a rapid loss of vitamin A from the plasma, liver, adrenals and thymus. Of the organs studied, the thymus appeared to be the most sensitive to treatment. The steroid-mediated depression of plasma and tissue contents of vitamin A was reversed when animals were treated with corticosterone in combination with vitamin A.