1.
Eur J Med Chem
; 42(9): 1176-83, 2007 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17418453
RESUMO
The synthesis of a new series of 1beta-methylcarbapenems having cyclic sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. A particular compound (IIIi) having 2-methyl-[1,2,6]thiadiazinan-1,1-dioxide moiety showed the most potent antibacterial activity.