RESUMO
In this work, gum acacia (GA)/poly(sodium acrylate) semi-interpenetrating polymer networks (Semi-IPN) have been fabricated via free radical initiated aqueous polymerization of monomer sodium acrylate (SA) in the presence of dissolved Gum acacia (GA), using N,N'-methylenebisacrylamide (MB) as cross-linker and potassium persulphate (KPS) as initiator. The semi-IPNs, synthesized, were characterized by various techniques such as X-ray diffraction (XRD), thermo gravimetric analysis (TGA) and Fourier transform infrared (FTIR) spectroscopy. The dynamic water uptake behavior of semi-IPNs was investigated and the data were interpreted by various kinetic models. The equilibrium swelling data were used to evaluate various network parameters. The semi-IPNs were used as template for the in situ preparation of silver nanoparticles using extract of Syzygium aromaticum (clove). The formation of silver nanoparticles was confirmed by surface plasmon resonance (SPR), XRD and transmission electron microscopy (TEM). Finally, the antibacterial activity of GA/poly(SA)/silver nanocomposites was tested against E. coli.
Assuntos
Acrilatos/síntese química , Antibacterianos/síntese química , Goma Arábica/química , Hidrogéis/síntese química , Nanopartículas Metálicas/química , Nitrato de Prata/química , Acrilatos/farmacologia , Adsorção , Antibacterianos/farmacologia , Óleo de Cravo/química , Testes de Sensibilidade a Antimicrobianos por Disco-Difusão , Escherichia coli/efeitos dos fármacos , Química Verde , Hidrogéis/farmacologia , Teste de Materiais , Nanocompostos/química , Polimerização , Difração de Raios XRESUMO
In recent past magnetic nanoparticles have been explored for a number of biomedical applications due to their superparamagnetic moment with high magnetic saturation value. For these biomedical applications, magnetic nanoparticles require being monodispersed so that the individual nanoparticle has almost identical physico-chemical properties for biodistribution, bioelimination and contrast imaging potential. Further, the surface functionalization/modification of magnetic nanoparticles ultimately facilitate the protein or DNA separation, detection and magnetic resonance imaging contrast, drug delivery and hyperthermia applications. The essential goal of this review is to evaluate the recent advances of magnetic nanoparticles for tumor, brain targeting and hyperthermia applications.
Assuntos
Sistemas de Liberação de Medicamentos/instrumentação , Sistemas de Liberação de Medicamentos/métodos , Nanotecnologia/instrumentação , Nanotecnologia/métodos , Neoplasias/tratamento farmacológico , Animais , Humanos , Hipertermia Induzida , Magnetismo , Camundongos , Modelos Químicos , Nanopartículas/química , RatosRESUMO
The ethanolic extracts, various fractions and two pure compounds isolated from the plant N. arbortris were tested against Encephalomyocarditis Virus (EMCV) and Semliki Forest Virus (SFV). Pronounced in vitro virus inhibitory activity was observed with the ethanolic and n-butanol fractions as well as with the pure compounds arbortristoside A and arbortristoside C. In addition, ethanolic extracts and n-butanol fraction protected EMCV infected mice to the extent of 40 and 60% respectively against SFV at a daily dose of 125 mg/kg body weight.
Assuntos
Vírus da Encefalomiocardite/efeitos dos fármacos , Oleaceae , Sementes , Vírus da Floresta de Semliki/efeitos dos fármacos , 1-Butanol/administração & dosagem , 1-Butanol/farmacologia , Administração Oral , Infecções por Alphavirus/tratamento farmacológico , Infecções por Alphavirus/mortalidade , Animais , Infecções por Cardiovirus/tratamento farmacológico , Infecções por Cardiovirus/mortalidade , Chlorocebus aethiops , Relação Dose-Resposta a Droga , Glicosídeos/administração & dosagem , Glicosídeos/farmacologia , Injeções Intraperitoneais , Iridoides/administração & dosagem , Iridoides/farmacologia , Camundongos , Fitoterapia/métodos , Extratos Vegetais/farmacologia , Células VeroRESUMO
Seventy three marine plant extracts were tested in vitro in chick embryo fibroblast cell culture and their anti-vaccinia virus activity was evaluated in terms of reduction in number of plaques by the extracts. Only seven extracts were found to show the activity. Sargassum wightii, a seaweed had the highest activity, reducing 65 per cent of plaques formed by vaccinia virus.