[Effect of rifampicin, lincomycin and staphylococcal vaccine on the beta-lysin activity of the blood serum of animals infected with Staphylococcus]. / Vliianie rifampitsina, linkomitsina i stafilokokkovoi vaktsiny na aktivnost' beta-lizinov v syvorotke krovi zhivotnykh, infitsirovannykh stafilokokkom.

Changes in activity of beta-lysins in blood serum were studied in the time course on albino mice infected with staphylococci and treated with rifampicin, lincomycin and inactivated staphylococcal vaccine administered in combination or alone. It was shown that staphylococcal infection lowered activity of the serum beta-lysins in the animals and therapeutic use of inactivated staphylococcal vaccine stimulated beta-lysin activity. Therapeutic use of rifampicin or lincomycin under the same conditions lowered activity of beta-lysins. The inhibitory effect of rifampicin was less pronounced. Combined use of the antibiotics and the vaccine promoted an increase in activity of beta-lysins as compared to the use of the antibiotics alone.

[Effect of antibiotic therapy and vaccine therapy on the phagocytic reaction in mice infected with Staphylococcus]. / Vliianie antibiotikoterapii i vaktsinoterapii na fagotsitarnuiu reaktsiiu u myshei, infitsirovannykh stafilokokkom.

The time course of changes in the activity, intensity and completeness of phagocytosis with leukocytes of the peritoneal exudate was studied on mice with experimental staphylococcal infection treated with rifampicin, lincomycin and inactivated staphylococcal vaccine used alone or in combination. It was shown that immunization of the animals with inactivated staphylococcal vaccine promoted stimulation of the phagocytic defense. Rifampicin and lincomycin applied therapeutically induced a decrease in the activity, intensity and completeness of phagocytosis. It should be noted that rifampicin had a less pronounced inhibitory effect than lincomycin. The combined use of vaccine and antibiotics with therapeutic purposes promoted an increase in phagocytosis as compared to the use of the antibiotics alone. The combined therapy sometimes resulted in completeness of phagocytosis making it reach the control values (the 10th and 15th days, rifampicin and vaccine). It should be noted that a more pronounced stimulation of the activity, intensity and completeness of the phagocytosis was observed with the use of the combination of rifampicin and the vaccine.

[Effect of antibiotic and vaccine therapies on the succinate dehydrogenase and phosphatase activity of liver cells of mice infected with Staphylococcus]. / Vliianie antibiotikoterapii i vaktsinoterapii na aktivnost' suktsinatdegidrogenazy i fosfatazy v kletkakh pecheni u myshei, infitsirovannykh stafilokokkom.

Changes in the activity of succinate dehydrogenase (SDH), total and acid phosphatase (TP and AP) were studied in treatment of laboratory animals with rifampicin, lincomycin and with inactivated staphylococcal vaccine used alone or in combinations. It was shown that immunization of the animals with inactivated staphylococcal vaccine under conditions of experimental staphylococcal infection promoted stimulation of the enzyme activity. Rifampicin and lincomycin used for the treatment of such animals lowered the activity of the enzymes. The suppressing effect of the antibiotics increased with an increase in the period of their use. It should be noted that the inhibitory effect of rifampicin on the activity of SDH, TP and AP was less pronounced than that of lincomycin. The combined use of the vaccine and antibiotics for the treatment of the animals promoted an increase in the enzyme activity as compared to the use of the antibiotics alone. Sometimes the activity of SDH, TP and AP reached the control levels in such animals or the levels observed in the animals treated with the vaccine alone. Stimulation of the enzyme activity was more pronounced when the vaccine was used in combination with rifampicin.