1.
Bioorg Med Chem Lett
; 20(19): 5753-6, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20805031
RESUMO
Starting from an HTS derived hit 1, application of biostructural data facilitated rapid optimization to lead 22, a novel AMPA receptor modulator. This is the first demonstration of how structure based drug design can be exploited in an optimization program for a glutamate receptor.