The effect of arthroscopic surgery and intraarticular drug injection to the antioxidation system and lipid peroxidation at osteoarthritis of knee.

OBJECTIVE: To elucidate the effects of arthroscopy and intraarticular hyaluronan therapies on antioxidant enzyme activity and lipid peroxidation. METHODS: This study was conducted between January and May 2005, at the Department of Orthopedics and Traumatology, Suleyman Demirel University, Isparta, Turkey. A total of 60 patients with knee pain who were diagnosed as knee osteoarthritis according to the American College of Rheumatology (ACR) criteria were included in this study and randomly and equally divided into 4 groups. Intraarticular Hylan G-F 20 treatment was given to group 1 for 3 weeks. Intraarticular Hylan G-F 20 treatment plus oral vitamin E were administered to group 2 for 3 weeks. Only arthroscopy treatment was applied to the control group (group 3). Intraarticular Na-hyaluronate treatment was given to group 4 for 5 weeks. Blood and synovial fluid samples were taken from all the patients for biochemical analysis, and the following parameters were measured: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and malondialdehyde (MDA). RESULTS: There was no significant difference in blood SOD, CAT, GPx levels, and synovial SOD and GPx levels in groups treated with hyaluronan, when compared with the controls. However, there was a significant change in MDA levels in synovial fluid samples of group 1, group 2, and group 4, when compared with the controls. CONCLUSION: In knee osteoarthritis, intraarticular hyaluronan therapy following arthroscopy may diminish lipid peroxidation in synovial fluid.

A regression equation to predict true maximal oxygen consumption of taekwondo athletes using a field test.

OBJECTIVE: The purpose of the present study was to examine the validity of using a 20 meter multistage shuttle run test to estimate maximal oxygen uptake. METHODS: Twenty-two elite taekwondo athletes (11 male, 11 female, members of the Turkish young national team), participated in the study. The respiratory gas exchange parameters were measured using portable gas analysis system while shuttle run test was carried out. All tests were performed last August 2004, in the gymnasium of Suleyman Demirel University, Isparta, Turkey. RESULTS: Analysis of the test scores showed a mean score on gas analysis of 51.79 ml/kg/min and a mean score of 43.59 ml/kg/min on the shuttle run test. On average, the scores predicted by the shuttle run test were 16% lower than those for the gas analysis score. The correlation between the tests was significant at a level of r = 0.810. CONCLUSION: Maximal oxygen consumption (VO2 max) can be predicted from shuttle run test scores, but not as indicated with the test package. In order to obtain the true score one must apply a regression equation.