1.
Bioorg Med Chem Lett
; 13(4): 665-8, 2003 Feb 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12639554
RESUMO
Optimisation of the left-hand-side aryl moiety of a file compound screening hit against Staphylococcus aureus methionyl tRNA synthetase led to the identification of a series of potent nanomolar inhibitors. The best compounds showed excellent antibacterial activity against staphylococcal and enterococcal pathogens, including strains resistant to clinical antibiotics.