[The comparative efficacy of emoxipine and sodium oxybutyrate in experimental myocardial ischemia]. / Sravnitel'naia éffektivnost' émoksipina i oksibutirata natriia pri eksperimental'noi ishemii miokarda.

The efficacy of emoxypine (2-ethyl-6-methyl-3-hydroxypyridine chlorohydrate) versus sodium hydroxybutyrate in total and local ischemia followed by reperfusion was studied in the experiments on rat isolated hearts. Emoxypine in a dose of 1 nM in total ischemia was shown to have a protective action, by decreasing reperfusion contracture. In local ischemia, emoxypine, unlike sodium hydroxybutyrate, did not favour greater restoration of the amplitude of isolated heart contractions, but restored coronary flow and stabilized contraction frequency better than did sodium hydroxybutyrate.

[The use of 2-component myocardial contraction for assessing the mechanism of action of inotropic substances]. / Ispol'zovanie dvukhkomponentnogo sokrashcheniia miokarda dlia otsenki mekhanizme deistviia inotropnykh veshchestv.

The possibility of using two-component contraction of the myocardium to evaluate the mechanisms of action of cardiotropic pharmacological agents was studied. Caffeine, ouabain, low-natrium solution, varapamil, nifedipine and BAY K-8644 were used. It was concluded that the analysis of contraction component amplitude dynamics makes it possible to determine the effect of the pharmacological agents on the interrelated mechanisms of the delivery of Ca2+ into the myoplasm of cardiomyocytes from sarcoplasmic reticulum and through sarcolemma during a single cardiac cycle.