Formulation of Suppositories of Alum Produced from Bauxite Waste in Ghana for the Treatment of Hemorrhoid.

The study sought to formulate and evaluate suppositories using a locally produced brand of alum (Aw) obtained from bauxite waste generated at Awaso bauxite mine in the Western-North region of Ghana, for use in the treatment of hemorrhoids. The suppositories were formulated using shea butter modified, respectively, with amounts of beeswax and theobroma oil. In another development, theobroma oil was modified with different concentrations of beeswax. Drug-base interactions were investigated using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy. The suppositories were prepared using the hot melt and trituration methods. Quality control checks were carried out on the formulations. The evaluated parameters included physical characteristics (texture, presence or absence of entrapped air, and contraction holes), weight uniformity, disintegration time, drug content, and in vitro release profile of the alum from the formulated suppositories. An in vivo analysis was carried out on the most suitable formulation to ascertain its efficacy on inflamed tissues using croton oil-induced rectal inflammation in a rat model. A critical examination of the ATR-FTIR spectra revealed no drug-base interactions. The suppository formulations passed all Pharmacopoeia stated tests. The in vivo study revealed the use of suppositories ameliorated the croton oil-induced hemorrhoid in the rectoanal region of the rats.

Treating waste with waste: the potential of synthesized alum from bauxite waste for treating car wash wastewater for reuse.

This study assessed the contaminant removal potential of a low-cost alum synthesized from bauxite slime waste compared to industrial grade alum [Al2(SO4)3.18H2O] in treating car wash wastewater using standard jar tests. The synthesized alum was subsequently applied as a coagulant to test the short-term performance of a bench scale flocculation-flotation system for treating car wash wastewater. Coagulant dosages and mixing intensities were optimized for both coagulants and differences were analyzed with R using two-way ANOVA with Tukey's (HSD) post hoc testing. Per the jar tests, percentage removal of up to 99%, 34%, and 75% of turbidity, anionic surfactants (AS), and COD, respectively, was achieved with 90 mg/L of the synthesized alum compared to 100%, 37%, and 74% for industrial grade alum. Contaminant removal efficiencies of both coagulants were comparable (p > 0.05). However, coagulant dosage strongly influenced the removal of turbidity, AS, and COD (p < 0.05) while mixing intensity influenced all but COD. The bench-scale flocculation-flotation system completely removed turbidity (100%) and reduced AS and COD by up to 92% and 99% respectively. The results of this study demonstrate the potential of alum synthesized from bauxite slime waste as a cheaper alternative for industrial grade alum in wastewater recycling for the car wash industry.

Defluoridation of groundwater using aluminum-coated bauxite: Optimization of synthesis process conditions and equilibrium study.

There is no known effective treatment for fluoride-related health disorders, hence prevention through water defluoridation is necessary. This study explored the possibility of modifying the physico-chemical properties of bauxite, a locally available material in many countries including Ghana, by thermal treatment and an aluminum coating, for water defluoridation. The study mainly focused on investigating the effects of varying synthesis process conditions on the defluoridation efficiency of Granular Aluminum Coated Bauxite (GACB). GACB performed better than raw bauxite (RB) and was able to reduce fluoride concentration in groundwater from 5 ± 0.2 mg/L to ≤ 1.5 mg/L, World Health Organization (WHO) guideline. Based on nonlinear Chi-square (χ(2)) analysis, the best-fitting isotherm model for the fluoride-GACB system was in the order: Freundlich > Redlich-Perterson ≈ Langmuir > Temkin. The fluoride adsorption capacity of GACB (qmax = 12.29 mg/g) based on the Langmuir model was found to be either comparable or higher than the capacities of some reported fluoride adsorbents. Aluminum (Al) coating procedures optimized in this study could therefore be a useful approach for synthesizing an effective fluoride adsorbent using bauxite, a locally available material. Kinetic and isotherm analysis, thermodynamic calculations, as well as FTIR and Raman analysis suggested the mechanism of fluoride adsorption onto GACB was complex and involved both physical adsorption and chemisorption processes.