RESUMO
AIM: To specify immunological and pathogenetic aspects of imunophan use in aged patients with duodenal ulcer (DU). MATERIAL AND METHODS: Imunophan was given to 24 DU patients (mean age 62.0 +/- 1.5 years), in whom the size of ulcer varied from 0.6 to 2.1 cm. RESULTS: The patients on anti-ulcer therapy plus imunophan had a pain relief median 6.2 +/- 0.2 days (p < 0.001), control ones--11.8 +/- 0.1 days. The median of scarring duration in the test group was 16.2 +/- 0.2 days (p < 0.001), in the controls--23.8 +/- 0.3 days. In 3 (30.0%) cases the scars were rough. The count of T-lymphocytes in the study group increased from 53.1 +/- 0.6 to 65.1 +/- 0.2% (p < 0.001), of T-helpers/inductors--from 27.8 +/- 0.2 to 38.5 +/- 0.3% (p < 0.001), of cytotoxic T-lymphocytes--from 18.5 +/- 0.5 to 27.3 +/- 0.3 (p < 0.001), of B-lymphocytes--from 12.3 +/- 0.2 to 19.1 +/- 0.1% (p < 0.001). The therapy including imunophan reduced concentration of malonic dialdehide by 23.5%, trienic conjugates by 61.6%; raised the level of superoxide dismutase 1.6-fold, catalase 1.4-fold, glutathione reductase by 41.9% (p < 0.001). Neither immune status nor LPO-AOD changed significantly in patients on the basic therapy alone. CONCLUSION: The results obtained evidence for a positive action of imunophan on inflammation, immune status and antioxidant defense. Therefore, imunophan can be recommended as an adjuvant of basic anti-ulcer therapy in elderly and senile patients.
Assuntos
Adjuvantes Imunológicos/uso terapêutico , Úlcera Duodenal , Imunoglobulina A/imunologia , Oligopeptídeos/uso terapêutico , Adjuvantes Imunológicos/administração & dosagem , Adjuvantes Imunológicos/farmacologia , Progressão da Doença , Úlcera Duodenal/tratamento farmacológico , Úlcera Duodenal/imunologia , Úlcera Duodenal/fisiopatologia , Feminino , Humanos , Imunoglobulina A/efeitos dos fármacos , Leucócitos/metabolismo , Masculino , Malondialdeído/antagonistas & inibidores , Pessoa de Meia-Idade , Oligopeptídeos/administração & dosagem , Oligopeptídeos/farmacologia , Superóxido Dismutase/antagonistas & inibidoresRESUMO
General clinical examination, external respiratory function investigation, antrovent pharmacological tests were performed in 68 patients aged 28-52 years with chronic obstructive bronchitis (COB) admitted to the rehabilitation center after hospital treatment. Hyperbaric oxygenation improved general condition of the patients, normalized excessive free-radical lipid oxidation and antioxidant defense. It also improves the results of combined rehabilitation treatment, bronchial permeability, sensitivity of beta-2 bronchial receptors to sympathomimetics. This allows to reduce doses or discontinue sympathomimetics.
Assuntos
Oxigenoterapia Hiperbárica/métodos , Pneumopatias Obstrutivas/terapia , Adulto , Gasometria , Feminino , Humanos , Pneumopatias Obstrutivas/diagnóstico , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Resultado do TratamentoAssuntos
Bloqueadores dos Canais de Cálcio/uso terapêutico , Nifedipino/uso terapêutico , Doença Cardiopulmonar/tratamento farmacológico , Hemodinâmica/efeitos dos fármacos , Hemodinâmica/fisiologia , Humanos , Doença Cardiopulmonar/fisiopatologia , Respiração/efeitos dos fármacos , Respiração/fisiologiaRESUMO
The effect of niphangin (calcium antagonist) on the hemodynamics, gaseous exchange and course of the disease was studied in 65 patients with chronic obstructive bronchitis complicated by cor pulmonale. Synchronous registration of ECG, PCG, tetrapolar rheography, phlebography. It was found that niphangin used in the complex treatment of cor pulmonale allowed to improve the gaseous exchange, central and peripheral hemodynamics and effected favourably the course of the disease.