[Immunomodulating effect of vitamin A and E preparations during deep local cooling]. / Immunomoduliruiushchee deistvie preparatov vitaminov A i E pri glubokom lokal'nom okhlazhdenii.

It was experimentally established for the first time that cell cytokines of lymphatic nodes play an important role in the immunosuppression development in cases of deep local cooling. Vitamins A and E can be used for correcting the cytokine secretion and the immunocyte sensitivity to their action.

[Immunomodulating and antioxidant effects of vitamins A and E during air and immersion cooling]. / Immunomoduliruiushchee i antioksidantnoe deistvie vitaminov A i E pri vozdushnom i immersionnom okhlazhdenii.

An important factor in the immunosuppression development on cooling is the increase in lipid peroxidation rate in the cell membranes. It was found that vitamins A and E possess a high immunomodulating and antioxidant activity under the acute cold-induced stress conditions. Administration of these vitamins is expedient for patients suffered from cooling in air of by immersion.

[Immunomodulating effects of vitamin K preparations and its potentiation by riboxine in acute cold stress]. / Immunomoduliruiushchee deistvie preparatov vitamina K i ego usilenie riboksinom pri ostrom kholodovom stresse.

The vitamin K preparations phylloquinone, menadione, and vikasol produce an immunomodulant effect under acute cold-induced stress conditions. A combination of phylloquinone, menadione and riboxin provides an effective means of correcting the immunological reactivity and antioxidant state under the conditions of immersion cooling. The immunomodulant effect of naphthoquinones and riboxin is correlated with their antioxidant activty.

[Immunomodulating and antioxidant effects of magnetic and laser irradiation combined with administration of beta-carotene, essentiale, and riboxine during cold stress]. / Immunomoduliruiushchie antioksidantnye éffekty magnitolazernogo oblucheniia, sochetaiushchegosia s vvedeniem beta-karotina, éssentsiale i riboksina, pri kholodovom stresse.

We studied effects of beta-carotine, essentiale and riboxine on immunometabolic effects induced by laser or magnetic laser radiation in intact rats and rats exposed to immersion cold. We found that combination of laser or magnetic laser radiation with administration of beta-carotine or riboxine more effectively corrected antioxidant status and immunological reactivity than radiation alone or in combination with essentiale.

[The extracorporeal immunostimulating effect of terrilytin in staphylococcal infection]. / Ekstrakorporal'nyi immunostimuliruiushchii éffekt terrilitina pri stafilokokkovoi infektsii.

The intravenous injection of terrilytin-treated lymphocytes into rats infected with staphylococci enhances the formation of staphylococcal alpha antitoxin in the animals and the development of immune response to T-dependent antigen, such as sheep red blood cells (SRBC), but produces no effect on the development of immune response induced by T-independent antigen (lipopolysaccharide). Terrilytin-treated lymphocytes induce the release of the factor promoting the development of immune response to staphylococcal antigens and SRBC by spleen cells, incapable of adherence to plastic, but have no influence on the development of immune response to lipopolysaccharide in rats infected with staphylococci. At the same time in such rats spleen cells adhering to plastic take part in the transfer of signals from terrilytin-treated lymphocytes to nonadhering spleen cells of recipients.