[Diagnostic hysteroscopy in abnormal uterine bleeding. Five-years' experience]. / L'isteroscopia diagnostica nel sanguinamento uterino anomalo. Cinque anni di esperienza.

BACKGROUND: Hysteroscopy has acquired a central role in the clinical diagnosis of intrauterine pathologies. This study evaluated the feasibility, procedure modality, tolerability, complications and diagnostic accuracy of hysteroscopy in the management of patients with abnormal uterine bleeding (AUB). METHODS: This retrospective study was carried out on 512 women (age range: 38-80 years, mean age: 63) with AUB who attended our hysteroscopy outpatient service from January 1996 to December 2001. After undergoing transvaginal sonography, the patients were referred for further diagnostic studies. Ambulatory hysteroscopy without premedication was performed using a Hamou hysteroscope and physiological solution or CO(2) as distension medium. Guided biopsy with a Novak cannula completed the examination. When focal lesions were found, the patients were referred for surgical treatment (hysteroscopic resection, hysterectomy, etc.). Hysteroscopic and histologic findings were then compared. RESULTS: Locoregional or general anaesthesia was required in only 9.3% of cases to complete the examination. Overall, the examination was well tolerated; one case of serious complications (vagal syndrome which resolved rapidly) and 18 cases of shoulder blade pain were recorded. The hysteroscopic picture was normal in 25% of cases, benign pathology was diagnosed in 58.6% and suspected malignant neoplasia in 16.4%. Correlation rates between hysteroscopic and histologic diagnoses are reported for the various hysteroscopic pictures. CONCLUSIONS: Ambulatory hysteroscopy was shown to be a simple, safe, well tolerated and reliable procedure in the diagnosis of AUB across all age groups. Its widespread use can drastically reduce the need for conventional curettage, thereby increasing patient satisfaction and lowering costs.

[The effects of lesions in several zones of the brain on cell multiplication in the glandular epithelium of the rat small intestine]. / Effets de lésions de quelques zones de l'encéphale sur la multiplication cellulaire dans l'épithélium des glandes de l'intestin grêle chez le rat.

Radio-frequency lesions of tubero-infundibular region of the hypothalamus are followed by a significant increase of the mitotic rate in the small intestine glandular epithelium in rats. This increase does not occur when radio-frequency lesions are located in the anterior and posterior hypothalamus, in the dorsomedial thalamus and in the cerebral hemispheres.