RESUMO
This investigation was conducted to ascertain whether administration of L-carnitine and coenzyme Q10 could protect from the experimentally-induced hepatic lipid infiltration and glutathione content decrease in rats exposed to hyperbaric oxygen and prolonged alcohol administration. The results indicate that administration of L-carnitine and coenzyme Q10 in association reduces damage induced by chronic alcohol poisoning and hyperbaric oxygen. This protective action is more marked when L-carnitine and coenzyme Q10 are administered together. The combined complementary biochemical activity of these two compounds is discussed.
Assuntos
Carnitina/farmacologia , Etanol/toxicidade , Oxigenoterapia Hiperbárica , Fígado/metabolismo , Triglicerídeos/metabolismo , Ubiquinona/farmacologia , Animais , Doença Hepática Induzida por Substâncias e Drogas/metabolismo , Sinergismo Farmacológico , Glutationa/metabolismo , Peróxidos Lipídicos/metabolismo , Fígado/efeitos dos fármacos , Masculino , Ratos , Ratos WistarRESUMO
The ethanol-induced increased synthesis of fatty acids in the liver is enhanced by hyperbaric oxygen exposure. Both lipid peroxidation and glutathione depletion are involved in these hepatic alterations. Coenzyme A can intervene in these mechanisms. The administration of CoA prevents hepatic lipid infiltration and the glutathione reduction induced in the rats by ethanol and hyperbaric oxygen exposure.
Assuntos
Coenzima A/farmacologia , Etanol/toxicidade , Oxigenoterapia Hiperbárica , Fígado/metabolismo , Triglicerídeos/metabolismo , Animais , Fígado/efeitos dos fármacos , Cirrose Hepática Alcoólica/prevenção & controle , Masculino , Doenças Metabólicas/induzido quimicamente , Doenças Metabólicas/prevenção & controle , Ratos , Ratos Endogâmicos , Compostos de Sulfidrila/farmacologiaAssuntos
Oxigenoterapia Hiperbárica/efeitos adversos , Inibidores de Proteases/farmacologia , Ácido 4-Aminobenzoico/farmacologia , Aminocaproatos , Ácido Aminocaproico/farmacologia , Animais , Coenzima A/farmacologia , Feminino , Glutationa/farmacologia , Ácidos Cetoglutáricos/farmacologia , Masculino , Camundongos , Tiopronina/farmacologia , Uridina Difosfato Glucose/farmacologia , para-AminobenzoatosAssuntos
Oxigenoterapia Hiperbárica/efeitos adversos , Hepatopatias/prevenção & controle , Fígado/efeitos dos fármacos , Animais , Feminino , Glutationa/farmacologia , Glutationa/uso terapêutico , Ácidos Cetoglutáricos/farmacologia , Ácidos Cetoglutáricos/uso terapêutico , Hepatopatias/etiologia , Masculino , Camundongos , Tiopronina/farmacologia , Tiopronina/uso terapêutico , Uridina Difosfato Glucose/farmacologia , Uridina Difosfato Glucose/uso terapêuticoRESUMO
Hyperbaric oxygen may provoke lesions in various organs and tissues depending on the dose and application time. The toxic action mechanisms of oxygen are manifold. The pulmonary lesions that occur in mice submitted to various oxygen pressures are investigated. Anatomo-pathological examination revealed numerous alterations of various kinds depending on pressure used. Emphysema, pulmonary oedema and enormous inflammatory processes in the lung are the most frequent findings encountered in research.