Effects of Production Training With Ultrasound Biofeedback on Production and Perception of Second-Language English Tense-Lax Vowel Contrasts.

PURPOSE: This study investigated the efficacy of ultrasound biofeedback compared to a traditional acoustic input-only method in the second-language (L2) production training of English tense-lax vowel contrasts (/i-ɪ/ and /e-ɛ/). The relationship between the degrees of production and perception learning was also examined to explore a potential L2 production-perception link. METHOD: Using a pretest/training/posttest paradigm, two groups of native Mandarin speakers received three sessions of training, one with ultrasound and one with audio only. Perception performance was measured by accuracy in AX discrimination. Production performance was measured in terms of accuracy in repetition production and Euclidean distance between contrasting vowels. RESULTS: Both groups showed significant improvements in posttest production and perception tasks. Additionally, the training benefits were retained 6 weeks after training. The two groups, however, did not differ significantly in training gains; nor was there a significant correlation between training-induced changes in perception and production performance. CONCLUSIONS: The results indicate that ultrasound feedback is similarly effective as the audio-only training in improving the L2 production of English tense-lax contrasts and the benefits transferred to perception. The lack of correlation between production and perception gains suggests that the two modalities need to be separately trained to achieve desired L2 learning outcomes.

Alterative effects of an oral alginate extract on experimental rabbit osteoarthritis.

BACKGROUND: Osteoarthritis (OA) is a common joint disease that causes disabilities in elderly. However, few agents with high efficacy and low side effects have been developed to treat OA. In this study, we evaluated the effects of the alginate extract named CTX in OA cell and rabbit models. RESULTS: CTX was formulated by hydrolyzing sodium alginate polymers with alginate lyase and then mixing with pectin. HPLC was used to analyze the CTX content. Human chondrosarcoma SW1353 cells treated with interleukin-1ß were used as OA model cells to investigate the effects of CTX on chondrocyte inflammation and anabolism. CTX at concentrations up to 1000 µg/ml exerted low cytotoxicity. It inhibited the gene expression of proinflammatory matrix metalloproteinases (MMPs) including MMP1, MMP3 and MMP13 in a dose-dependent manner and increased the mRNA level of aggrecan, the major proteoglycan in articular cartilage, at 1000 µg/ml. Thirteen-week-old New Zealand White rabbits underwent a surgical anterior cruciate ligament transection and were orally treated with normal saline, glucosamine or CTX for up to 7 weeks. Examinations of the rabbit femur and tibia samples demonstrated that the rabbits taking oral CTX at a dosage of 30 mg/kg/day suffered lesser degrees of articular stiffness and histological cartilage damage than the control rabbits. CONCLUSIONS: The gene expression profiles in the cell and the examinations done on the rabbit cartilage suggest that the alginate extract CTX is a pharmaco-therapeutic agent applicable for OA therapy.