Application of hyperbaric oxygen therapy in diabetic foot ulcers: A meta-analysis.

Hyperbaric oxygen therapy (HBOT) has been used in patients with diabetic foot ulcers (DFU) for many years, but its clinical efficacy is still controversial. Therefore, this study explored the efficacy of HBOT applied to DFU by means of meta-analysis. PubMed, Cochrane Library, Embase, CNKI and Wanfang databases were searched, from database inception to October 2023, and published randomised controlled trials (RCTs) of HBOT in DFU were collected. Two investigators independently screened the collected literature, extracted relevant data and assessed the quality of the literature. Review Manager 5.4 software was applied for data analysis. Twenty-nine RCTs with 1764 patients were included. According to the combined results, when compared with conventional treatment, HBOT significantly increased the complete healing rate of DFUs (46.76% vs. 24.46%, odds ratio [OR]: 2.83, 95% CI: 2.29-3.51, p < 0.00001) and decreased the amputation rate (26.03% vs. 45.00%, OR: 0.41, 95% CI: 0.18-0.95, p = 0.04), but the incidence of adverse events was significantly higher in patients (17.37% vs. 8.27%, OR: 2.49, 95% CI: 1.35-4.57, p = 0.003), whereas there was no significant difference in the mortality (6.96% vs. 12.71%, OR: 0.52, 95% CI: 0.21-1.28, p = 0.16). Our results suggest that HBOT is effective in increasing the complete healing rate and decreasing the amputation rate in patients with DFUs, but increases the incidence of adverse events, while it has no significant effect on mortality.

[Comparative study on selenium and amino acids content in leaves of planted and wild Scutellaria baicalensis].

Scutellaria baicalensis is one of the most important Chinese herbs. It is widely used in Asian medicine to improve impaired brain function and to treat headaches, and used to treat prostate cancer. It is also known to be anti-inflammatory and antifungal, and also seems to have antiviral properties, including possible effectiveness against HIV. Scutellaria baicalensis tea and other products are in development. In the present study, the content of selenium (Se) in leaves of planted and wild Scutellaria baicalensis was determined by fluorescence photometer. The contents of 18 kinds of amino acids in the leaves of planted and wild Scutellaria baicalensis were determined with amino acids instruments. The results showed that the two kinds of leaves were rich in Se content, and the content of Se in planted Scutellaria baicalensis (0.051 microg x g(-1)) was not significantly different from that in wild one (0.051 microg x g(-1), alpha = 0.05). The amino acids, of which the total content was up to 14.62% and 10.25% separately, were rich in both planted and wild Scutellaria baicalensis. Among the 18 kinds of amino acids, aspartic acid, glutamic acid and leucine were comparatively high in leaves of planted and wild Scutellaria baicalensis. There are 8 kinds of amino acids essential to human body, which were higher in leaves of planted Scutellaria baicalensis than those of wild one. This study, for the first time, determined Se and amino acids content in Scutellaria baicalensis and concluded that the leaves of planted type have Se and amino acids content not lower or higher than that of wild type, and the planted type could be a good substitute of wild type in the development of Scutellaria baicalensis products. This study also provided useful data for explaining the multifunction of Scutellaria baicalensis and theological basis for developing its medical and edible value.