RESUMO
ETHNOPHARMACOLOGICAL RELEVANCE: Network pharmacology is a new discipline based on systems biology theory, biological system network analysis, and multi-target drug molecule design specific signal node selection. The mechanism of action of TCM formula has the characteristics of multiple targets and levels. The mechanism is similar to the integrity, systematization and comprehensiveness of network pharmacology, so network pharmacology is suitable for the study of the pharmacological mechanism of Chinese medicine compounds. AIM OF THE STUDY: The paper summarizes the present application status and existing problems of network pharmacology in the field of Chinese medicine formula, and formulates the research ideas, up-to-date key technology and application method and strategy of network pharmacology. Its purpose is to provide guidance and reference for using network pharmacology to reveal the modern scientific connotation of Chinese medicine. MATERIALS AND METHODS: Literatures in this review were searched in PubMed, China National Knowledge Infrastructure (CNKI), Web of Science, ScienceDirect and Google Scholar using the keywords "traditional Chinese medicine", "Chinese herb medicine" and "network pharmacology". The literature cited in this review dates from 2002 to 2022. RESULTS: Using network pharmacology methods to predict the basis and mechanism of pharmacodynamic substances of traditional Chinese medicines has become a trend. CONCLUSION: Network pharmacology is a promising approach to reveal the pharmacology mechanism of Chinese medicine formula.
Assuntos
Medicamentos de Ervas Chinesas , Medicina Tradicional Chinesa , Medicamentos de Ervas Chinesas/farmacologia , Medicamentos de Ervas Chinesas/química , Farmacologia em Rede , Sistemas de Liberação de Medicamentos , Biologia de SistemasRESUMO
One new flavonoid glycoside (1) and one new triterpenoid cinnamate (2) were isolated from Nervilia fordii. The structures of 1 and 2 were determined by extensive NMR and HRESIMS to be 7-O-ß-d-glucopyranosylapigenin-8-C-ß-d-glucopyranosyl-(1 â 2)-ß-d-glucopyranoside and 24(S/ß)-dihydrocycloeucalenol-3-(Z)-p-hydroxycinnamate, respectively.
Assuntos
Cinamatos/isolamento & purificação , Medicamentos de Ervas Chinesas/isolamento & purificação , Flavonoides/isolamento & purificação , Glicosídeos/isolamento & purificação , Orchidaceae/química , Plantas Medicinais/química , Triterpenos/isolamento & purificação , Cinamatos/química , Medicamentos de Ervas Chinesas/química , Flavonoides/química , Glicosídeos/química , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Folhas de Planta/química , Estereoisomerismo , Triterpenos/químicaRESUMO
OBJECTIVE: To study chemical constituents of contained in roots of Pterospermum heterophyllum. METHOD: The chemical constituents of P. heterophyllum were separated and purified by silica gel, sephadex LH-20, ODS column chromatography and preparative HPLC. Their structures were identified by spectroscopic techniques. RESULT: Ten compounds were separated and identified as asperglaucide (1), 2-methoxy4-hydroxyphenol-1-O-beta-D-apiofuranosyl (1-->6)-O-beta-D-glucopyranoside (2), 5, 5'-dimethoxy-9-beta-D-xylopyranosyl-(-) -isolariciresinol(3), (-)-epicatechin (4), eriodictyol (5), taxifolin (6), 3beta-hydroxy-12-en-28-ursolic acid (7), 2beta, 3beta-dihydroxy-12-en-28-oleanolic acid (8), quercetin (9), cholest-4-en-3-one (10). CONCLUSION: Compounds 1-10 were separated from this plant for the first time.
Assuntos
Medicamentos de Ervas Chinesas/química , Malvaceae/química , Raízes de Plantas/química , Cromatografia/métodos , Medicina Tradicional ChinesaRESUMO
From the water-soluble extract of the aerial part of herbal plant Nervilia fordii, three new cycloartane glycosides, named as nervisides A (1), B (2), and C (3), were isolated. Their structures were elucidated through a combination of spectroscopic analysis and hydrolysis. At the same time, the new compounds were tested for their cytotoxicities in vitro against human tumor cell lines (CNE, Hep-2, and HepG2) using MTT method.