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1.
J Anim Sci ; 82(4): 1136-45, 2004 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-15080336

RESUMO

Two experiments were conducted to evaluate the effects of protein and lipid sources on cholesterol, AA, and fatty acid content, and on biological performance of juvenile Pacific white shrimp, Litopenaeus vannamei (Boone). In Exp. 1, seven isonitrogenous and isocaloric diets were prepared using fish meal; soybean meal; casein; fish meal + soybean meal; fish meal + casein; soybean meal + casein; and fish meal + soybean meal + casein. In Exp. 2, seven isonitrogenous and isocaloric diets were prepared using fish oil; soy oil; poultry fat; fish oil + soy oil; fish oil + poultry fat; soy oil + poultry fat; and fish oil + soy oil + poultry fat. Nine shrimp (average BW 570 mg) were stocked per 60-L tank, with three tanks per diet in each experiment. Shrimp were fed to apparent satiation twice daily for 28 d. Protein sources affected shrimp cholesterol, feed consumption, feed efficiency, protein consumption, protein efficiency ratio, and crude body fat (P < or = 0.05), but not weight gain, survival, hepatosomatic index, body protein, ash, and AA composition. Body (without hepatopancreas) cholesterol concentrations were the highest in shrimp fed the diet containing fish meal (0.81%), lowest for those fed the casein diet (0.64%), and intermediate in the other dietary treatment groups (range 0.71 to 0.74%). Lipid source also affected shrimp body cholesterol, body fatty acid profiles, and fatty acid profiles in the hepatopancreas (P < or = 0.05), but not growth performance, body protein, fat, ash, and cholesterol concentrations in the hepatopancreas. Shrimp fed the fish oil diet had the highest body cholesterol (0.75%), whereas those fed the soy oil or poultry fat diets were lowest (0.66 and 0.65%, respectively). Results indicate that by replacing fish meal and fish oil with soybean meal and soy oil, shrimp growth performance is not affected, but body cholesterol concentration is reduced.


Assuntos
Ração Animal , Colesterol/metabolismo , Gorduras na Dieta/metabolismo , Proteínas Alimentares/metabolismo , Penaeidae/crescimento & desenvolvimento , Penaeidae/metabolismo , Fenômenos Fisiológicos da Nutrição Animal , Animais , Aquicultura , Gorduras na Dieta/administração & dosagem , Proteínas Alimentares/administração & dosagem , Óleo de Soja/administração & dosagem , Óleo de Soja/metabolismo , Proteínas de Soja/administração & dosagem , Proteínas de Soja/metabolismo , Aumento de Peso
2.
Zhongguo Zhong Yao Za Zhi ; 26(3): 194-7, 2001 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-12525041

RESUMO

OBJECTIVE: To investigate the changes of copper, zinc and selenium levels in rat tissues after long-term oral administration of Realgar. METHODS: Rats were given Realgar with dosage of 50, 150, 450 mg.kg-1.d-1 for 5 weeks, and the concentrations of copper, zinc and selenium in different rat tissues as well as the contents of metallothionein in rat liver and kidney were determined with atomic absorption and hydride generation-atomic fluorescent technique. The total amount of copper excreted from feces and urine of each rat 5 days before the rat was killed was also measured. RESULTS: No significant changes of levels of copper, zinc and selenium in rat tissues were found after administration of low and middle dosages of Realgar. But higher dosage (450 mg.kg-1.d-1) of Realgar administration could induce a small but significant decrease of zinc concentration in hearts and a increase of copper contents in spleen and tibia, as well as twice more copper concentration of kidney. CONCLUSION: Copper deposit in kidney was the most significant change found among the trace elements levels in rat tissues, and this might be one of the mechanisms for kidney toxicity of Realgar.


Assuntos
Cobre/metabolismo , Rim/metabolismo , Materia Medica/toxicidade , Sulfetos/toxicidade , Administração Oral , Animais , Arsenicais/administração & dosagem , Fígado/metabolismo , Masculino , Materia Medica/administração & dosagem , Metalotioneína/metabolismo , Distribuição Aleatória , Ratos , Ratos Wistar , Selênio/metabolismo , Sulfetos/administração & dosagem , Zinco/metabolismo
3.
Free Radic Biol Med ; 25(2): 160-8, 1998 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-9667491

RESUMO

The antioxidant properties of prenylflavones, isolated from Artocarpus heterophyllus Lam., was evaluated in this study. Among them, artocarpine, artocarpetin, artocarpetin A, and cycloheterophyllin diacetate and peracetate had no effect on iron-induced lipid peroxidation in rat brain homogenate. They also did not scavenge the stable free radical 1,1-diphenyl-2-picrylhydrazyl. In contrast, cycloheterophyllin and artonins A and B inhibited iron-induced lipid peroxidation in rat brain homogenate and scavenged 1,1-diphenyl-2-picrylhydrazyl. They also scavenged peroxyl radicals and hydroxyl radicals that were generated by 2,2'-azobis(2-amidinopropane) dihydrochloride and the Fe3+-ascorbate-EDTA-H2O2 system, respectively. However, they did not inhibit xanthine oxidase activity or scavenge superoxide anion, hydrogen peroxide, carbon radical, or peroxyl radicals derived from 2,2'-azobis(2,4-dimethylvaleronitrile) in hexane. Moreover, cycloheterophyllin and artonins A and B inhibited copper-catalyzed oxidation of human low-density lipoprotein, as measured by fluorescence intensity, thiobarbituric acid-reactive substance and conjugated-diene formations and electrophoretic mobility. It is concluded that cycloheterophyllin and artonins A and B serve as powerful antioxidants against lipid peroxidation when biomembranes are exposed to oxygen radicals.


Assuntos
Antioxidantes/farmacologia , Flavonoides/química , Flavonoides/farmacologia , Sequestradores de Radicais Livres/química , Sequestradores de Radicais Livres/farmacologia , Picratos , Animais , Bepridil/análogos & derivados , Bepridil/análise , Bepridil/metabolismo , Compostos de Bifenilo , Química Encefálica , Sistema Livre de Células , Medicamentos de Ervas Chinesas , Radicais Livres , Peróxido de Hidrogênio/metabolismo , Radical Hidroxila/metabolismo , Peroxidação de Lipídeos/efeitos dos fármacos , Peróxidos/metabolismo , Ratos , Ratos Wistar , Rosales , Relação Estrutura-Atividade , Superóxidos/metabolismo , Substâncias Reativas com Ácido Tiobarbitúrico/análise
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