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Métodos Terapêuticos e Terapias MTCI
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1.
Sci Data ; 9(1): 235, 2022 05 26.
Artigo em Inglês | MEDLINE | ID: mdl-35618736

RESUMO

Medicinal plants have demonstrated therapeutic potential for applicability for a wide range of observable characteristics in the human body, known as "phenotype," and have been considered favorably in clinical treatment. With an ever increasing interest in plants, many researchers have attempted to extract meaningful information by identifying relationships between plants and phenotypes from the existing literature. Although natural language processing (NLP) aims to extract useful information from unstructured textual data, there is no appropriate corpus available to train and evaluate the NLP model for plants and phenotypes. Therefore, in the present study, we have presented the plant-phenotype relationship (PPR) corpus, a high-quality resource that supports the development of various NLP fields; it includes information derived from 600 PubMed abstracts corresponding to 5,668 plant and 11,282 phenotype entities, and demonstrates a total of 9,709 relationships. We have also described benchmark results through named entity recognition and relation extraction systems to verify the quality of our data and to show the significant performance of NLP tasks in the PPR test set.


Assuntos
Processamento de Linguagem Natural , Plantas Medicinais , Humanos , Fenótipo , PubMed
2.
Environ Pollut ; 272: 116180, 2021 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-33445152

RESUMO

Although liquid products derived from the pyrolysis of biomass are promising for the production of petroleum-like hydrocarbon fuels, the catalytic burden of hydrodeoxygenation must be reduced to achieve feasible upgrading processes. Herein, mild hydrotreating of an acid-rich biomass pyrolysis oil (bio-oil) with an unusually high total acid number (588 mg KOH/g bio-oil) was performed to stabilize the low-quality bio-oil. Ru-added TiO2-supported transition metal catalysts stabilized the bio-oil by reducing its acidity more compared to what could be achieved by Ru-free catalysts; this process also leads to lower loss of organic compounds compared to when using a Ru/TiO2 catalyst. Based on the performance of transition metal catalysts, including Ni, Co, and Cu, supported on TiO2, tungstate-zirconia, or SiO2, supported bimetallic catalysts were prepared by adding Ru to the TiO2-supported metal catalysts. The bimetallic catalysts Ru/Ni/TiO2 and Ru/Co/TiO2 exhibited good decarboxylation activity for the removal of carboxylic acids and a higher yield of organic compounds compared to that provided by Ru, which can be deemed appropriate for feedstocks when hydrodeoxygenation needs to suppress the loss of organic reactants. Using these catalysts, the carboxylic acid concentration was reduced to 319-323 mg KOH/g bio-oil with organic yields of 62-63 wt% at reaction temperatures 150-170 °C lower than the temperature required for direct conversion of carboxylic acids to alcohols or deoxygenates. The improved catalytic hydrotreating activity of Ru-added transition metals can be attributed to the high acid site densities of these catalysts along with their improved hydrogenation activities.


Assuntos
Biocombustíveis , Dióxido de Silício , Catálise , Temperatura Alta , Óleos de Plantas , Polifenóis
3.
Artigo em Inglês | MEDLINE | ID: mdl-26980517

RESUMO

In recent years, herbs have been researched for new drug candidates because they have a long empirical history of treating diseases and are relatively free from side effects. Studies to scientifically prove the medical efficacy of herbs for target diseases often spend a considerable amount of time and effort in choosing candidate herbs and in performing experiments to measure changes of marker genes when treating herbs. A computational approach to recommend herbs for treating diseases might be helpful to promote efficiency in the early stage of such studies. Although several databases related to traditional Chinese medicine have been already developed, there is no specialized Web tool yet recommending herbs to treat diseases based on disease-related genes. Therefore, we developed a novel search engine, HerDing, focused on retrieving candidate herb-related information with user search terms (a list of genes, a disease name, a chemical name or an herb name). HerDing was built by integrating public databases and by applying a text-mining method. The HerDing website is free and open to all users, and there is no login requirement. Database URL: http://combio.gist.ac.kr/herding.


Assuntos
Doença/genética , Medicina Herbária , Ferramenta de Busca , Doença de Alzheimer/tratamento farmacológico , Doença de Alzheimer/genética , Humanos , Internet , Interface Usuário-Computador
4.
Phys Rev Lett ; 111(24): 243901, 2013 Dec 13.
Artigo em Inglês | MEDLINE | ID: mdl-24483661

RESUMO

Multiple scatterings occurring in a turbid medium attenuate the intensity of propagating waves. Here, we propose a method to efficiently deliver light energy to the desired target depth in a scattering medium. We measure the time-resolved reflection matrix of a scattering medium using coherent time-gated detection. From this matrix, we derive and experimentally implement an incident wave pattern that optimizes the detected signal corresponding to a specific arrival time. This leads to enhanced light delivery at the target depth. The proposed method will lay a foundation for efficient phototherapy and deep-tissue in vivo imaging in the near future.


Assuntos
Radiação Eletromagnética , Luz , Nefelometria e Turbidimetria/métodos , Espalhamento de Radiação , Nefelometria e Turbidimetria/instrumentação
5.
Fertil Steril ; 88(4 Suppl): 1220-31, 2007 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-17601599

RESUMO

OBJECTIVE(S): To examine the effect of exogenous exposure to hydrogen peroxide (H(2)O(2)) and tumor necrosis factor (TNF)-alpha on mouse metaphase II (MII) oocyte spindle structure and to examine the potential benefits of supplementing the culture media with vitamin C. DESIGN: Prospective study. SETTING: Research laboratory in a tertiary hospital. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Microtubule changes and alterations in chromosomal alignment. RESULT(S): Both concentration- and time-dependent alterations were seen in spindle structure after exposure to H(2)O(2). An H(2)O(2) concentration as low as 12.5 microM increased the odds of an oocyte with altered microtubule and chromosome alignment (score >or=3) by 93%. Significantly increased damage was seen with increasing period of incubation. Higher scores were seen after exposure to both TNF-alpha alone and in combination with H(2)O(2) compared with controls. Changes in chromosomal alignment were comparable among the three groups. Oocytes coincubated with H(2)O(2) and vitamin C at 200 microM demonstrated less damage compared with those with H(2)O(2) alone. CONCLUSION(S): Oxidative stress results in concentration and time-dependent alterations in the spindle structure and augments the effects induced by TNF-alpha. Proper oocyte handling in vitro may help reduce oxidative insult, thus improving the oocyte quality. Antioxidants may have a protective effect and need to be further evaluated.


Assuntos
Metáfase/fisiologia , Oócitos/metabolismo , Estresse Oxidativo/fisiologia , Fuso Acromático/metabolismo , Fator de Necrose Tumoral alfa/toxicidade , Animais , Feminino , Peróxido de Hidrogênio/toxicidade , Metáfase/efeitos dos fármacos , Camundongos , Oócitos/efeitos dos fármacos , Oócitos/ultraestrutura , Estresse Oxidativo/efeitos dos fármacos , Estudos Prospectivos , Fuso Acromático/efeitos dos fármacos , Fuso Acromático/ultraestrutura
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