RESUMO
The results of treatment with human colostrum in 6 babies with protracted infectious diarrhea from enteropathogenic E. coli and/or Salmonella are reported. Active diarrhea was present in 5 cases and the 6th was a carrier. Remission was obtained in cases with diarrhea and all showed increase in weight. Negativeness of stool cultures was achieved in four cases and in the other two, the bacteriologic control was not complete. One patient died from a secondary pulmonary infectious problem. As an average, all patients showed rise in secretory IgA and in IgG measured at the duodenal fluid level and in comparison with a control group, there were statistically significant differences. Serum immunoglobulins showed no changes following administration of human colostrum. Although the number of patients reported is small, the results obtained may be considered favorable.
Assuntos
Colostro , Diarreia Infantil/tratamento farmacológico , Imunoglobulina A/administração & dosagem , Administração Oral , Diarreia Infantil/microbiologia , Escherichia coli/isolamento & purificação , Infecções por Escherichia coli/tratamento farmacológico , Infecções por Escherichia coli/microbiologia , Humanos , Lactente , Recém-Nascido , Salmonella/isolamento & purificação , Infecções por Salmonella/tratamento farmacológico , Infecções por Salmonella/microbiologiaRESUMO
A case is reported of a girl with acrodermatitis enteropathica who was treated succesfully with zinc sulfate at 75 mg/day PO. A remarkable increase in weight was evident through the course of 12 months of treatment, reaching the percentile 50 by the age of 3 years; however the height remained close to percentile 3. Possibly, the zinc deficiency is secondary to a selective defect in the metal absorption. Treatment with zinc sulfate in these patients substitutes with greate advantages the use of diiodohydroxyquin. Possibly, zinc supplements must be given for a life time to these patients.