RESUMO
The effects of a single, variable dose (5 to 200 mg) of RU38486 (RU486) (Roussel-Uclaf, Paris, France) in the first half of the luteal phase of the menstrual cycle were studied in 30 normal fertile volunteers. Quantitative histologic techniques were employed, and the results were compared with normal ranges derived from a separate, normal, fertile population. It was found that RU486 inhibited glandular secretory activity, accelerated degenerative changes, induced various vascular changes, increased stromal but not glandular mitotic activity, and did not affect the predecidual reaction. The superiority of morphometric analysis over traditional dating criteria was demonstrated in this study of endometrial responses to an exogenously administered agent. In addition, it was found that temperature drop occurred in 56%, menstrual induction in 43%, luteolysis in 24%, mood change in 23%, and thirst sensation in 3% of women studied. Both menstrual induction and changes in hypothalamic function after the administration of RU486 occurred independently of luteolysis and so were likely to be the direct result of progesterone receptor blockade in these organs. Menstrual induction was significantly related to the dose given and the day on which RU486 was administered. Mood change was significantly related to the day on which RU486 was given. Most of the effects of RU486 occurred around 48 hours after its administration.
PIP: The effects of a single, variable dose (5-200 mg) of RU38486 (RU486; Roussel-Uclaf, Paris, France) in the 1st 1/2 of the luteal phase of the menstrual cycle were studied in 30 normal fertile volunteers. Quantitative histologic techniques were employed, and the results were compared with normal ranges derived from a separate, normal, fertile population. It was found that RU486 inhibited glandular secretory activity, accelerated degenerative changes, induced various vascular changes, increased stromal but not glandular mitotic activity, and did not affect the predecidual reaction. The superiority of morphometric analysis over traditional dating criteria was demonstrated in this study of endometrial responses to an exogenously administered agent. In addition, it was found that temperature drop occurred in 56%, menstrual induction in 43%, luteolysis in 24%, mood change in 23%, and thirst sensation in 3% of the women studied. Both menstrual induction and changes in hypothalamic function after the administration of RU486 occurred independently of luteolysis and thus were likely to be the direct result of progesterone receptor blockade in these organs. Menstrual induction was significantly related to the dose given and the day on which RU486 was administered. Mood change was significantly related to the day on which RU486 was given. Most of its effects occurred around 48 hours after administration.
Assuntos
Estrenos/farmacologia , Progestinas/antagonistas & inibidores , Receptores de Progesterona/efeitos dos fármacos , Adolescente , Adulto , Afeto/efeitos dos fármacos , Regulação da Temperatura Corporal/efeitos dos fármacos , Permeabilidade Capilar/efeitos dos fármacos , Feminino , Humanos , Hipotálamo/efeitos dos fármacos , Fase Luteal/efeitos dos fármacos , Hormônio Luteinizante/sangue , Menstruação/efeitos dos fármacos , Mifepristona , Mitose/efeitos dos fármacos , Progesterona/análise , Saliva/análiseAssuntos
Menstruação , Progesterona/sangue , Ligação Proteica , Radioimunoensaio , Animais , Carvão Vegetal , Galinhas , Dextranos , Feminino , Cabras/imunologia , Humanos , Soros Imunes , Métodos , Oximas , Petróleo , Soroalbumina Bovina , Succinatos , TrítioRESUMO
In the Cardiff Family Planning Association Clinic 330 men have been sterilized during the past 20 months. Selection for operation was made after a detailed discussion between husband, wife, and a Family Planning Association doctor, and with the general practitioner's agreement. The outpatient operation was performed under local anaesthetic by a surgeon. It was regarded as being successful or complete when two semen analyses showed azoospermia at an interval of one month.