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1.
Heart Rhythm ; 16(6): 873-878, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-30590192

RESUMO

BACKGROUND: The presence of inferior vena cava filters (IVCFs) has been considered a relative contraindication to electrophysiology (EP) procedures that require transfemoral venous placement of multiple catheters and/or long sheaths. There are inadequate data related to complex EP procedures in this population. OBJECTIVE: The purpose of this study was to describe the experience of a single high-volume center with respect to complex EP procedures in patients with IVCFs. METHODS: Patients with IVCFs undergoing complex EP procedures between 2004 and 2018 were identified. Clinical characteristics, IVCF type, procedural findings, and complications were analyzed. RESULTS: Fifty complex ablation procedures were performed in 40 patients (mean age 63.8 ± 10.9 years; 68% men). The mean IVCF dwell time was 69.1 ± 19.1 months, and 48 patients (96%) were on chronic oral anticoagulation. Procedures included ablation of atrial fibrillation (n = 21), ventricular tachycardia (n = 20), supraventricular tachycardia (n = 3), cavotricuspid isthmus flutter (n = 3), supraventricular tachycardia and cavotricuspid isthmus flutter (n = 1), and transvenous lead extraction (n = 3). Twenty procedures included quadripolar catheters (mean 1.4 ± 0.75), and 33 procedures involved deflectable decapolar catheters (mean 1.7 ± 0.47). Long sheaths were used in 35 cases (mean 1.63 ± 0.49) and intracardiac echocardiography in 38. In 4 cases (involving 3 patients), the IVCF was occluded and could not be crossed. There were no procedural complications related to the IVCF. CONCLUSION: The substantial majority of IVCFs in patients presenting for complex EP procedures were patent and easily crossed under fluoroscopic guidance. The presence of an IVCF should not discourage operators from performing procedures that require transfemoral deployment of multiple catheters and/or sheaths.


Assuntos
Arritmias Cardíacas/cirurgia , Cateterismo Cardíaco , Cateterismo Periférico , Veia Femoral , Filtros de Veia Cava , Trombose Venosa , Anticoagulantes/uso terapêutico , Arritmias Cardíacas/classificação , Cateterismo Cardíaco/efeitos adversos , Cateterismo Cardíaco/instrumentação , Cateterismo Cardíaco/métodos , Ablação por Cateter/métodos , Cateterismo Periférico/efeitos adversos , Cateterismo Periférico/instrumentação , Cateterismo Periférico/métodos , Catéteres , Remoção de Dispositivo/métodos , Técnicas Eletrofisiológicas Cardíacas/métodos , Estudos de Viabilidade , Feminino , Veia Femoral/diagnóstico por imagem , Veia Femoral/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Avaliação de Processos e Resultados em Cuidados de Saúde , Cirurgia Assistida por Computador/métodos , Trombose Venosa/tratamento farmacológico , Trombose Venosa/cirurgia
2.
Circ Arrhythm Electrophysiol ; 5(2): 287-94, 2012 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22139886

RESUMO

BACKGROUND: The single-procedure efficacy of pulmonary vein isolation (PVI) is less than optimal in patients with persistent atrial fibrillation (AF). Adjunctive techniques have been developed to enhance single-procedure efficacy in these patients. We conducted a study to compare 3 ablation strategies in patients with persistent AF. METHODS AND RESULTS: Subjects were randomized as follows: arm 1, PVI + ablation of non-PV triggers identified using a stimulation protocol (standard approach); arm 2, standard approach + empirical ablation at common non-PV AF trigger sites (mitral annulus, fossa ovalis, eustachian ridge, crista terminalis, and superior vena cava); or arm 3, standard approach + ablation of left atrial complex fractionated electrogram sites. Patients were seen at 6 weeks, 6 months, and 1 year; transtelephonic monitoring was performed at each visit. Antiarrhythmic drugs were discontinued at 3 to 6 months. The primary study end point was freedom from atrial arrhythmias off antiarrhythmic drugs at 1 year after a single-ablation procedure. A total of 156 patients (aged 59±9 years; 136 males; AF duration, 47±50 months) participated (arm 1, 55 patients; arm 2, 50 patients; arm 3, 51 patients). Procedural outcomes (procedure, fluoroscopy, and PVI times) were comparable between the 3 arms. More lesions were required to target non-PV trigger sites than a complex fractionated electrogram (33±9 versus 22±9; P<0.001). The primary end point was achieved in 71 patients and was worse in arm 3 (29%) compared with arm 1 (49%; P=0.04) and arm 2 (58%; P=0.004). CONCLUSIONS: These data suggest that additional substrate modification beyond PVI does not improve single-procedure efficacy in patients with persistent AF. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00379301.


Assuntos
Fibrilação Atrial/cirurgia , Ablação por Cateter/métodos , Veias Pulmonares/cirurgia , Idoso , Eletrocardiografia , Técnicas Eletrofisiológicas Cardíacas , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Recidiva , Resultado do Tratamento
3.
Heart Rhythm ; 8(8): 1169-76, 2011 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-21392586

RESUMO

BACKGROUND: The substrate for ventricular tachycardia (VT) in nonischemic cardiomyopathy (NICM) has a predilection for the basolateral left ventricle with right bundle branch block VT morphology. OBJECTIVE: The purpose of this study was to describe a unique group of NICM patients with septal VT substrate. METHODS: Between 1999 and 2010, 31 (11.6%) of 266 patients with NICM undergoing VT ablation had septal substrate and no lateral involvement. Mean age was 59 ± 12 years, and ejection fraction was 30% ± 14%. Eight patients had heart block. RESULTS: Cardiac magnetic resonance showed septal delayed enhancement in 8 of 9 patients. Electroanatomic mapping demonstrated bipolar low voltage (<1.5 mV) extending from the basal septum in 22 of 31 patients. The remaining 9 patients had normal endocardial bipolar voltage but abnormal unipolar septal voltage (<8.3 mV) consistent with intramural abnormalities. Epicardial mapping in 14 patients showed no scar in 9 and patchy basal left ventricular summit scar in 5. VTs were mapped to the septal substrate, with 62% having right bundle branch block morphology and V(2) precordial transition pattern break in 17% suggesting periseptal exit. After substrate and targeted VT ablation, no VT was inducible in 66% and no "clinical targeted" VT in 86%. Over a mean follow-up of 20 ± 28 months, VT recurred in 10 (32%) patients. CONCLUSION: Isolated septal VT substrate is uncommon in NICM. Biventricular low-voltage zones extending from the basal septum are characteristic, but septal scarring can be entirely intramural as evidenced by unipolar/bipolar electrograms and imaging. Multiple unmappable morphologies are the rule, often requiring several procedures aggressively targeting the septal substrate to achieve moderate long-term VT control.


Assuntos
Cardiomiopatias/fisiopatologia , Ablação por Cateter , Técnicas Eletrofisiológicas Cardíacas , Septos Cardíacos/fisiopatologia , Taquicardia Ventricular/fisiopatologia , Taquicardia Ventricular/terapia , Adulto , Idoso , Cardiomiopatias/patologia , Mapeamento Epicárdico , Feminino , Septos Cardíacos/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Taquicardia Ventricular/tratamento farmacológico , Taquicardia Ventricular/patologia
4.
Circ Arrhythm Electrophysiol ; 4(1): 49-55, 2011 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-21131557

RESUMO

BACKGROUND: Patients with nonischemic left ventricular cardiomyopathy (LVCM) and ventricular tachycardia (Vt) have complex 3-dimensional substrate with variable involvement of the endocardium (ENDO) and epicardium (EPI). The purpose of this study was to determine whether ENDO unipolar (UNI) mapping with a larger electric field of view could identify EPI low bipolar (BIP) voltage regions in patients with LVCM undergoing Vt ablation. METHODS AND RESULTS: The reference value for normal ENDO unipolar voltage was determined from 6 patients without structural heart disease. Consecutive patients undergoing Vt ablation over an 8-year period with detailed (>100 points) LV ENDO and EPI mapping and normal LV ENDO BIP voltage were identified. From this cohort, we compared patients with structurally normal hearts and normal EPI BIP voltage (EPI-, group 1) with patients with LVCM and low LV EPI BIP voltage regions present (EPI+, group 2). Confluent regions of ENDO UNI and EPI BIP low voltage (>2 cm(2)) were measured. The normal signal amplitude was >8.27 mV for LV ENDO UNI electrograms. Detailed LV ENDO-EPI maps in 5 EPI- patients were compared with 11 EPI+ patients. Confluent ENDO UNI low-voltage regions were seen in 9 of 11 (82%) of the EPI+ (group 2) patients compared with none of 5 EPI- (group 1) patients (P<0.001). In all 9 patients with ENDO UNI low voltage, the ENDO UNI low-voltage regions were directly opposite to an area of EPI BIP low voltage (61% ENDO UNI-EPI BIP low-voltage area overlap). CONCLUSIONS: EPI arrhythmia substrate can be reliably identified in most patients with LVCM using ENDO UNI voltage mapping in the absence of ENDO BIP abnormalities.


Assuntos
Cardiomiopatias/fisiopatologia , Técnicas Eletrofisiológicas Cardíacas/métodos , Endocárdio/fisiopatologia , Pericárdio/fisiopatologia , Taquicardia Ventricular/diagnóstico , Taquicardia Ventricular/fisiopatologia , Disfunção Ventricular Esquerda/fisiopatologia , Adulto , Idoso , Mapeamento Potencial de Superfície Corporal/métodos , Estudos de Casos e Controles , Ablação por Cateter , Eletrocardiografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Taquicardia Ventricular/cirurgia
5.
Heart Rhythm ; 7(3): 312-22, 2010 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-20097621

RESUMO

BACKGROUND: Ventricular arrhythmias are known to originate from the aortic sinus of Valsalva. OBJECTIVE: The purpose of this study was to identify the characteristics associated with ventricular arrhythmias originating from the right coronary cusp-left coronary cusp (RCC-LCC) commissure. METHODS: Thirty-seven consecutive patients with ventricular arrhythmias originating from the aortic cusp region were studied. Intracardiac echocardiography and electroanatomic mapping were used to define coronary cusp anatomy and catheter position. Ventricular arrhythmias from the RCC-LCC commissure were compared with ventricular arrhythmias originating from other sites in the aortic cusp region. RESULTS: Nineteen (51%) ventricular arrhythmias had an anatomic origin at the RCC-LCC commissure. Eighteen ventricular arrhythmias originated from other aortic cusp sites (4 right cusp, 7 left cusp, 3 left ventricular endocardium, 4 left ventricular epicardium anterior to aortic valve). A QS morphology in lead V(1) with notching on the downward deflection was present in 15 of 19 ventricular arrhythmias originating from the RCC-LCC commissure compared to 2 of 18 ventricular arrhythmias from other aortic cusp sites (P <.01). At the site of earliest activation, 13 of 19 patients with RCC-LCC ventricular arrhythmias had late potentials in sinus rhythm compared to 1 of 18 ventricular arrhythmias from other aortic cusp sites (P <.01). The site of successful ablation was confirmed to be above the aortic valve plane in 15 (79%) of 19 patients with RCC-LCC ventricular arrhythmias. CONCLUSION: RCC-LCC aortic cusp ventricular arrhythmias are common and have a QS morphology in lead V(1) with notching on the downward deflection with precordial transition at lead V(3). In the majority of cases, the site of successful ablation has late potentials in sinus rhythm.


Assuntos
Eletrocardiografia , Técnicas Eletrofisiológicas Cardíacas , Seio Aórtico/fisiopatologia , Taquicardia Ventricular/fisiopatologia , Complexos Ventriculares Prematuros/fisiopatologia , Adulto , Idoso , Vasos Coronários/fisiopatologia , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Taquicardia Ventricular/etiologia , Complexos Ventriculares Prematuros/etiologia
6.
Pacing Clin Electrophysiol ; 33(4): 520-4, 2010 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-20025702

RESUMO

A 73-year-old woman with a history of paroxysmal atrial fibrillation, sinus node dysfunction, bilateral breast cancer, and extensive chest radiation developed progressive edema, dyspnea, and recurrent pleural effusions soon after single-chamber pacemaker implantation. Thoracentesis yielded a diagnosis of chylothorax, and progressive refractory anasarca developed. A computed tomography angiogram suggested obstruction of the superior vena cava and left subclavian vein despite outpatient therapeutic anticoagulation. Autopsy confirmed venous thrombosis, along with mediastinal fibrosis. The presumed etiology of the chylothorax and anasarca was obstruction of the atretic central venous structures following pacemaker implantation, critically impairing the already tenuous venous and lymphatic drainage. (PACE 2010; 520-524).


Assuntos
Fibrilação Atrial/terapia , Neoplasias da Mama/radioterapia , Marca-Passo Artificial/efeitos adversos , Implantação de Prótese/efeitos adversos , Síndrome da Veia Cava Superior/etiologia , Idoso , Anticoagulantes/uso terapêutico , Quilotórax/diagnóstico , Dispneia/etiologia , Dispneia/patologia , Evolução Fatal , Feminino , Fibrose/patologia , Humanos , Doenças do Mediastino/patologia , Derrame Pleural/etiologia , Derrame Pleural/patologia , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/patologia , Síndrome do Nó Sinusal/terapia , Veia Subclávia/patologia , Síndrome da Veia Cava Superior/tratamento farmacológico
7.
Europace ; 9(2): 137-42, 2007 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-17272336

RESUMO

AIMS: Integrated bipolar implantable cardioverter-defibrillator (ICD) leads use the distal high-voltage coil as both the ventricular sensing anode and the distal shocking electrode. Mechanical interactions between the distal ICD coil and other intracardiac leads have been reported to result in electrical oversensing and inappropriate ICD therapies. We sought to determine whether covering sleeves over the high-voltage coils of an integrated bipolar ICD lead could prevent sensed artefact from mechanical lead interactions. METHODS AND RESULTS: Endotak Reliance 0157 and Endotak Reliance-G 0185 leads, the latter with expanded polytetrafluoroethylene (ePTFE) sleeves covering the high-voltage coils, were connected to ICD generators and the leads were submerged in saline. Device programmers were used to communicate with the ICD generators, providing real-time electrogram recording throughout testing. A series of mechanical interactions were performed with the ICD leads, including sliding and striking each distal coil against metal and non-metal components of other ICD and pacemaker leads. All direct metal-metal interactions resulted in sensed electrical artefact, including interactions between the bare ICD coil and another bare ICD coil or metal pacemaker ring. Identical mechanical interactions where metal-metal contact was prevented due to an interposed ePTFE covering sleeve were electrically silent with no sensed artefact. CONCLUSIONS: A covering sleeve over the distal high-voltage coil of an integrated bipolar ICD lead can mechanically shield the lead from metal-metal interactions, which might otherwise result in sensed artefact and inappropriate ICD therapies or withholding of pacing output. This finding has implications for lead selection when a new ICD lead is to be implanted adjacent to abandoned intracardiac leads or lead fragments.


Assuntos
Desfibriladores Implantáveis , Cardioversão Elétrica/instrumentação , Artefatos , Eletrocardiografia , Eletrodos Implantados , Técnicas Eletrofisiológicas Cardíacas , Humanos , Metais , Politetrafluoretileno , Reprodutibilidade dos Testes , Cloreto de Sódio
8.
J Cardiovasc Electrophysiol ; 18(1): 69-74, 2007 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17081214

RESUMO

INTRODUCTION: Radiofrequency catheter ablation can effectively treat patients with refractory atrial fibrillation (AF). Very late AF recurrence (> or = 12 months post-ablation) is uncommon and may represent a unique patient cohort. METHODS AND RESULTS: A nested case-control study was performed in the cohort who underwent AF ablation at the University of Pennsylvania to characterize patients who develop very late AF recurrence after ablation. The procedure consisted of isolation of pulmonary veins (PVs) demonstrating triggers and elimination of non-PV triggers initiating AF. Twenty-seven (7.9%) patients with very late recurrence were compared to 219 patients without recurrence and > or = 12 months of follow-up. The mean age was 54.6 +/- 11.3 years and 79% were men. Very late recurrence patients more likely weighed >200 lbs (70% vs 55%, P = 0.01); during initial ablation had fewer PVs isolated (2.8 +/- 1.1 vs 3.3 +/- 1.0, P = 0.03); and were less likely to have right inferior PV isolation (37% vs 61%, P = 0.02), less likely to have isolation of all PVs (30% vs 56%, P = 0.01), and more likely to have non-PV triggers (30% vs 11% OR 3.4(95% CI, 1.3-8.7), P = 0.01). PV reconnectivity and new triggers were found in the majority of patients with very late recurrence of AF who underwent repeat ablation. CONCLUSION: Very late recurrence of AF more likely occurred in patients >200 lbs who demonstrated non-PV triggers and did not undergo right inferior PV isolation. The majority of patients undergoing repeat ablation for very late recurrence demonstrated PV reconnectivity and new non-PV and PV triggers not observed during the initial ablation.


Assuntos
Fibrilação Atrial/epidemiologia , Ablação por Cateter , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Fibrilação Atrial/diagnóstico , Fibrilação Atrial/cirurgia , Ecocardiografia Transesofagiana , Técnicas Eletrofisiológicas Cardíacas , Feminino , Seguimentos , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Pennsylvania/epidemiologia , Período Pós-Operatório , Prognóstico , Recidiva , Reoperação , Estudos Retrospectivos , Fatores de Tempo
9.
Circulation ; 110(10): 1197-201, 2004 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-15337702

RESUMO

BACKGROUND: Percutaneous epicardial mapping and ablation are successful in some patients with ventricular epicardial reentry circuits but may be impossible when pericardial adhesions are present, such as from prior cardiac surgery. The purpose of this study was to evaluate the feasibility of direct surgical exposure of the pericardial space to allow catheter epicardial mapping and ablation in the electrophysiology laboratory when percutaneous access is not feasible. METHODS AND RESULTS: In 6 patients with prior cardiac surgery or failed percutaneous pericardial access, a subxiphoid pericardial window was attempted. In all 6 patients, manual lysis of adhesions exposed the epicardial surface of the heart through a small subxiphoid incision and allowed placement of an 8F sheath into the pericardial space under direct vision. Access to the diaphragmatic surface of the heart with ablation catheters was achieved in all patients, and catheter manipulation to the lateral and anterior walls was possible in 4 patients. Three-dimensional electroanatomic voltage maps revealed low-amplitude regions in the inferior or posterior left ventricular epicardium. A total of 16 ventricular tachycardias were induced, and 14 were abolished by radiofrequency ablation. Ablation was limited by intrapericardial defibrillator patches adherent to the likely target region in 2 patients. All patients had chest pain consistent with pericarditis early after the procedure that resolved within a few days. There were no other complications. CONCLUSIONS: A direct surgical subxiphoid epicardial approach in the electrophysiology laboratory is feasible for patients with difficult pericardial access who require ablation of epicardial arrhythmia foci.


Assuntos
Ablação por Cateter/métodos , Técnicas Eletrofisiológicas Cardíacas/métodos , Pericárdio/cirurgia , Taquicardia Ventricular/cirurgia , Adulto , Idoso , Cardiomiopatias/complicações , Ablação por Cateter/efeitos adversos , Doença das Coronárias/complicações , Estudos de Viabilidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Dor Pós-Operatória/etiologia , Pericardite/etiologia , Pericárdio/fisiopatologia , Reoperação , Taquicardia Ventricular/etiologia , Taquicardia Ventricular/fisiopatologia , Aderências Teciduais/cirurgia , Processo Xifoide
10.
Pacing Clin Electrophysiol ; 27(7): 933-7, 2004 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-15271012

RESUMO

The virtual electrode model predicts that pacing stimulus strength should reflect proximity of the pacing electrode to excitable myocardium, allowing pacing threshold to assess radiofrequency (RF) ablation lesions and unexcitable scar. The purpose of this study is to correlate RF lesion size with pacing threshold and electrogram (EG) amplitude change at the ablation site. In four swine (32-58 kg, 20 ventricular RF lesions were created using a 4-mm tip electrode catheters under fluoroscopic and electroanatomic guidance. Unipolar pacing threshold and bipolar and unipolar EG amplitude were measured before and after ablation and compared with lesion size measured in the fixed, serially sectioned tissue. Lesion diameter ranged from 6.4 to 19 mm and volume ranged from 29 to 1920 mm3. Ablation increased the pacing threshold by 320%, from 0.9 +/- 0.3 to 3.6 +/- 2.6 mA, P < 0.001. The change in pacing threshold correlated with lesion volume R = 0.88, P < 0.001). Linear regression predicts that lesion volume (mm3) = 160 X rise in pacing threshold + 13. Ablation reduced peak to peak bipolar EG amplitude by 56%, from 2.5 +/- 2.0 mV to 1.1 +/- 0.6 mV (P = 0.005). Unipolar EG amplitude diminished by only 22% from 4.0 +/- 1.6 to 3.2 +/- 0.9 mV postablation (P = 0.005). The correlations of lesion volume with change in either bipolar R = 0.14, P = 0.6) or unipolar R = 0.18, P = 0.6) EG amplitude were poor. Pacing threshold correlates with RF ablation lesion size, consistent with the virtual electrode model. In normal myocardium, change in pacing threshold is likely to be a better marker of lesion size than electrogram amplitude.


Assuntos
Estimulação Cardíaca Artificial , Ablação por Cateter , Eletrocardiografia , Ventrículos do Coração/patologia , Animais , Técnicas Eletrofisiológicas Cardíacas , Ventrículos do Coração/cirurgia , Masculino , Suínos
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