RESUMO
A new triterpenoid, 2alpha-,3beta,-,19alpha-trihydroxy-urs-12-ene-24,28-dioic acid (1), along with two known compounds. 3beta-acetoxy-urs-12-ene-11-one (2) and vomifoliol (3), was isolated from stems of Stelmatocryprton khasianum for the first time. Their structures were elucidated on the basis of chemical and spectroscopic methods.
Assuntos
Medicamentos de Ervas Chinesas/química , Extratos Vegetais/isolamento & purificação , Triterpenos/isolamento & purificação , Espectroscopia de Ressonância Magnética , Modelos Químicos , Triterpenos/químicaRESUMO
OBJECTIVE: To study the chemical constituents of Stelmatocrypton khasinum. METHOD: Using chromatographic methods to isolate compounds from S. khasinum and chemical and spectral methods to elucidate their structures. RESULT: Eight compounds, cleomiscosin A(1), 4-methoxy salicylicaldehyde(2), vanillin(3), isovanillin(4), 4-methoxy salicylic acid(5), isovanillic acid(6), 2,4-dihydroxy-benzoic acid(7) and 4-hydroxy-benzoic acid(8) were isolated from the stem of S. khasianum. CONCLUSION: Except compound 2, all the compounds were obtained from this plant for the first time.
Assuntos
Apocynaceae/química , Dioxanos/isolamento & purificação , Plantas Medicinais/química , Benzaldeídos/química , Benzaldeídos/isolamento & purificação , Cumarínicos , Dioxanos/química , Estrutura MolecularRESUMO
OBJECTIVE: To separate the constituents from Eucommia ulmoides. METHOD: The constituents were separated by the repeated chromatography and identified by spectral methods. RESULT: The seven compounds were obtained, which were kaempferol(1), quercetin(2), astragalin(3), hirsutin(4), rutin(5), 3,4-dihydrobenzonic acid(6), ethyl glucopyranoside(7). CONCLUSION: Compounds 3-7 were obtained from leaves of E. ulmoides for the first time.
Assuntos
Eucommiaceae/química , Flavonoides/isolamento & purificação , Quempferóis , Plantas Medicinais/química , Alcaloides/química , Alcaloides/isolamento & purificação , Flavonoides/química , Folhas de Planta/química , Rutina/química , Rutina/isolamento & purificaçãoRESUMO
Eight bioactive triterpenoid saponins (1-8) were isolated from the seeds of Aesculus chinensis, four of which are novel compounds. The major saponins were identified as escin Ia (1), Ib (2), isoescin Ia (3) and Ib (4), while the new compounds were identified as 22alpha-tigloyl-28-acetylprotoaescigenin-3beta-O-¿beta -D-glucopyranos yl (1-2) ¿beta-D-glucopyranosyl (1-4)-beta-D-glucopyranosiduronic acid (escin IVc, 5), 22alpha-angeloyl-28-acetylprotoaescigenin-3beta-O-¿bet a-D-glucopyrano syl (1-2) ¿beta-D-glucopyranosyl (1-4)-beta-D-glucopyranosiduronic acid (escin IVd, 6), 28-tigloylprotoaescigenin-3beta-O-¿beta-D-glucopyranosyl (1-2) ¿beta-D-glucopyranosyl (1-4)-beta-D-glucopyranosiduronic acid (escin IVe, 7), and 28-angeloylprotoaescigenin-3beta-O-¿beta-D-glucopyranosyl (1-2) ¿beta-D-glucopyranosyl (1-4)-beta-D-glucopyranosiduronic acid (escin IVf, 8). The structures were determined by chemical and spectroscopic methods. All the above compounds were evaluated for their inhibitory activity against HIV-1 protease.