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Biomacromolecules ; 25(4): 2302-2311, 2024 Apr 08.
Artigo em Inglês | MEDLINE | ID: mdl-38507248

RESUMO

Photodynamic therapy (PDT) employs photosensitizers to convert nearby oxygen into toxic singlet oxygen (1O2) upon laser light irradiation, showing great potential as a noninvasive approach for tumor ablation. However, the therapeutic efficacy of PDT is essentially impeded by π-π stacking and the aggregation of photosensitizers. Herein, we propose a tumor microenvironment-triggered self-adaptive nanoplatform to weaken the aggregation of photosensitizers by selenium-based oxidation at the tumor site. The selenide units in a selenium-based porphyrin-containing amphiphilic copolymer (PSe) could be oxidized into hydrophilic selenoxide units, leading to the nanoplatform self-expansion and stretching of the distance between intramolecular porphyrin units. This process could provide a better switch to greatly reduce the aggregation of photosensitive porphyrin units, generating more 1O2 upon laser irradiation. As verified in a series of in vitro and in vivo studies, PSe could be efficiently self-adapted at tumor sites, thus significantly enhancing the PDT therapeutic effect against solid tumors and minimizing side effects.


Assuntos
Nanopartículas , Neoplasias , Fotoquimioterapia , Porfirinas , Selênio , Humanos , Fármacos Fotossensibilizantes/farmacologia , Fármacos Fotossensibilizantes/uso terapêutico , Microambiente Tumoral , Selênio/uso terapêutico , Nanopartículas/uso terapêutico , Oxigênio , Neoplasias/tratamento farmacológico , Neoplasias/patologia , Polímeros/uso terapêutico , Porfirinas/farmacologia , Linhagem Celular Tumoral
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