RESUMO
The virus-inhibiting and immunostimulating activity of Soviet preparations, maleic anhydride copolymers, was demonstrated in alpha-, flavi-, and bunyavirus infections. Positive results were obtained in subcutaneous and intraperitoneal inoculations of the preparations used in prophylactic and therapeutic-prophylactic schedules. Stimulation of vaccination immunity was observed after combined use of copolymers and the vaccine against Eastern equine encephalomyelitis.
Assuntos
Adjuvantes Imunológicos/uso terapêutico , Antivirais/uso terapêutico , Encefalite Transmitida por Carrapatos/tratamento farmacológico , Encefalomielite Equina/tratamento farmacológico , Furanos/uso terapêutico , Febre Hemorrágica da Crimeia/tratamento farmacológico , Anidridos Maleicos/uso terapêutico , Polímeros/uso terapêutico , Animais , Avaliação Pré-Clínica de Medicamentos , Quimioterapia Combinada , Vírus da Encefalite Equina do Leste/imunologia , Vírus da Encefalite Transmitidos por Carrapatos/imunologia , Encefalite Transmitida por Carrapatos/imunologia , Encefalite Transmitida por Carrapatos/prevenção & controle , Encefalomielite Equina/imunologia , Encefalomielite Equina/prevenção & controle , Vírus da Febre Hemorrágica da Crimeia-Congo/imunologia , Febre Hemorrágica da Crimeia/imunologia , Febre Hemorrágica da Crimeia/prevenção & controle , Imunidade/efeitos dos fármacos , Camundongos , Vacinas Virais/uso terapêuticoRESUMO
A comparative study of the antiviral effect of interferon inducers from the group of natural double-stranded RNAs (yeast plasmid dsRNA, phage phi 6 and phage f2 dsRNAs was carried out on the model of experimental tick-borne encephalitis. The possibility of inducing up to 60% protection against 10 LD50 of TBE virus by prophylactic inoculation of interferon inducers alone was demonstrated. The therapeutic effect was observed only with yeast dsRNA (30% protection when the inducer was administered 4 hours after virus infection of mice). The prophylactic effect of inoculation of interferon inducers (yeast dsRNA and f2 dsRNA) to immune mice correlated with the protective effect of inducers alone. At the same time, the therapeutic effect of inoculation of yeast dsRNA to immune animals (4 hours after TBE virus, 40% protection) was more marked. In the therapeutic use of f2 dsRNA for pre-immunized animals a synergetic effect of the preparation was observed (56.7% protection in 4 hours and 26.7% protection 24 hours postinfection).
Assuntos
Antivirais/uso terapêutico , Encefalite Transmitida por Carrapatos/tratamento farmacológico , RNA de Cadeia Dupla/uso terapêutico , Animais , Avaliação Pré-Clínica de Medicamentos , Quimioterapia Combinada , Vírus da Encefalite Transmitidos por Carrapatos/imunologia , Indutores de Interferon/uso terapêutico , Camundongos , Plasmídeos , RNA Fúngico/uso terapêutico , RNA Viral/uso terapêutico , Fatores de Tempo , Vacinas Virais/uso terapêuticoRESUMO
Comparative investigations of the combined use of vaccines and interferon in tick-borne encephalitis, herpes, and acute encephalomyelitis of man showed that up to 78% of animal protection against 10--50 LD50 of intraperitoneally inoculated viruses could be achieved. Vaccination alone provided up to 56% survival of the infected mice, while administration of interferon subcutaneously or intraperitoneally in a dose of 800 units (53,300 units per 1 kilo body weight) 18--20 hours before virus gave a survival rate of 36%. The use of vaccine in combination with an interferon inducer, phage of f2 RNA, in tick-borne encephalitis gave up to 75% survival of the infected mice. Four hours after administration, interferon could be detected in mouse sera in a concentration up to 640 units/ml which in immune mice accumulated more rapidly and remained at a higher level 18 hours after inoculation of the inducer.