RESUMO
Multicytokine therapy may be useful to counteract radiation-induced myelosuppression. We assessed the stem cell factor + glycosylated erythropoietin + pegylated granulocyte colony-stimulating factor combination (SEG) as an emergency treatment. SEG in highly irradiated monkeys efficacy appeared to be restricted to granulopoiesis. Early administration of Erythropoietin did not prevent radiation-induced anemia.
Assuntos
Citocinas/uso terapêutico , Pancitopenia/tratamento farmacológico , Lesões Experimentais por Radiação/tratamento farmacológico , Animais , Transfusão de Sangue , Citocinas/administração & dosagem , Avaliação Pré-Clínica de Medicamentos , Quimioterapia Combinada , Emergências , Eritropoetina/administração & dosagem , Eritropoetina/uso terapêutico , Filgrastim , Fator Estimulador de Colônias de Granulócitos/administração & dosagem , Fator Estimulador de Colônias de Granulócitos/uso terapêutico , Interleucina-3/administração & dosagem , Interleucina-3/uso terapêutico , Macaca fascicularis , Proteínas de Membrana/administração & dosagem , Proteínas de Membrana/uso terapêutico , Pancitopenia/sangue , Pancitopenia/etiologia , Pancitopenia/terapia , Polietilenoglicóis , Lesões Experimentais por Radiação/sangue , Lesões Experimentais por Radiação/etiologia , Lesões Experimentais por Radiação/terapia , Proteínas Recombinantes/administração & dosagem , Proteínas Recombinantes/uso terapêutico , Fator de Células-Tronco/administração & dosagem , Fator de Células-Tronco/uso terapêutico , Trombopoetina/administração & dosagem , Trombopoetina/uso terapêuticoRESUMO
In this study, 21 guinea pigs were submitted to a single high energy impulse noise (gun shot with blank projectiles). The auditory function was evaluated over a 7-day recovery period by recording the compound action potential (CAP) from the round window. The threshold shift and input/output function (CAP amplitude and delay function of the stimulus intensity) were studied at different frequencies. CAP amplitude fell after the noise trauma, especially at the lower sound level, resulting in a threshold shift. Latency was significantly increased. During recovery, whereas latency returned to its initial value, CAP amplitude gradually increased and, in half the animals, exceeded the control value for the higher levels of stimulus. This could have been because of progressive disinhibition or recruitment, and may correspond clinically to hyperacusis. These results are discussed referring to those obtained by other authors using other methods.