Effect of different mucosal and acrylic resin surface treatments in a denture retention model for patients with radiotherapy-induced xerostomia.

The purpose of this study was to determine the effect of oral moisturizing agents, denture adhesives, and surface treatments on the retention of an acrylic resin test base dislodged from the maxillary alveolar ridges of xerostomic radiotherapy patients. Acrylic resin test bases prepared for 10 edentulous xerostomia patients were subjected to 8 surface treatment methods: method 1 = untreated dry surface; method 2 = use of Biotène oral moisturizer; method 3 = use of Protefix denture adhesive; method 4 = combination of Biotène and Protefix; method 5 = sandblasting of test bases; method 6 = use of Biotène on sandblasted surface; method 7 = use of Protefix on sandblasted surface; method 8 = combination of Protefix and Biotène on sandblasted surface. After each treatment, a tensile testing apparatus was used to dislodge the inserted test bases, and force values (N) were recorded. A significant difference in retentive force was observed between the 4 Protefix groups and those that did not use denture adhesive (P < .001). There were no differences among the 4 combinations of denture adhesive treatments (P > .05). Sandblasting the denture surfaces did not increase retentive forces alone or in combination with any other treatments. Biotène oral moisturizing agent was used in 4 treatment methods, but only had a significant effect on increasing retentive force when used with a nonsandblasted surface (P < .05). Biotène had no effect on retentive force compared to a nonsandblasted surface without moisturizer or when it was used in combination with any other methods. Protefix denture adhesive offered the greatest improvement in retentive force. Sandblasting the intaglio surface did not improve retentive force. Biotène was reported to improve patient comfort but had minimal effect on retentive force; however, Biotène can be assumed to be a more advantageous method of increasing retention compared to sandblasting (P < .05).

Effects of continuous conditioning noise and light on the auditory- and visual-evoked potentials of the guinea pig.

Neurophysiological studies aiming to explore how the brain integrates information from different brain regions are increasing in the literature. The aim of the present study is to explore intramodal (binaural, binocular) and intermodal (audio-visual) interactions in the guinea pig brain through the observation of changes in evoked potentials by generalized continuous background activity. Seven chronically prepared animals were used in the study and the recordings were made as they were awake. Epidural electrodes were implanted to the skulls by using stereotaxic methods. Continuous light for retinal or continuous white noise for cochlear receptors were used as continuous conditioning stimuli for generalized stimulation. To evoke auditory or visual potentials, click or flash were used as transient imperative stimuli. The study data suggest that (a) white noise applied to one ear modifies the response to click in the contralateral ear which is a binaural interaction; (b) continuous light applied to one eye modifies the response to flash applied to the contralateral eye which is interpreted as a binocular interaction; (c) regardless of the application side, white noise similarly modified the response to flash applied to the either eye connoting a nonspecific effect of white noise on vision, independent from spatial hearing mechanisms; (d) on the other hand, continuous light, in either eye, did not affect the response to click applied to any ear, reminding a 'one-way' interaction that continuous aural stimulation affects visual response.

CPP and amlodipine alter the decrease in basal acetylcholine and choline release by audiogenic stimulus in hippocampus of ethanol-withdrawn rats in vivo.

Effects of N-methyl-D-aspartate (NMDA) receptor and Ca2+ channel antagonists on extracellular acetylcholine and choline release in the hippocampus of ethanol-withdrawn rats were investigated by in vivo microdialysis. Ethanol was administered to Wistar rats in a liquid diet for 28 days. Basal acetylcholine and choline levels significantly increased at the 24th hour of ethanol withdrawal syndrome (EWS). Either an NMDA receptor antagonist (+/-)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) or a calcium channel antagonist amlodipine was administered, and 15 min later, an audiogenic stimulus (100 dB, 1 min) was applied to rats. While audiogenic stimulus increased acetylcholine and had no effect on choline release in control rats, it decreased acetylcholine and increased choline release in ethanol-withdrawn rats. CPP (15 mg/kg) and amlodipine (20 mg/kg) reversed the decrement in acetylcholine and increment in choline release in EW rats. Their effects on acetylcholine and choline release were not different from saline in control rats. Therefore, our findings suggest that, (a) because of adaptive changes in EWS, decrease of the acetylcholine release following audiogenic stimulus may play a role in the triggering of seizures, (b) hippocampal glutamatergic pathway may play a role in the audiogenic stimulus induced decrement of acetylcholine release in EWS, (c) inhibition of this pathway by NMDA receptor and calcium channel antagonists may prevent triggering of the seizures.

Dynamics of the contralateral white noise-induced enhancement in the guinea pig's middle latency response.

The peak-to-peak amplitude of temporal middle latency response (MLR) of the guinea pig, evoked by a click in the contralateral ear, according to the recording side, is increased with the presence of continuous white noise (CWN) in the ipsilateral ear and this specialty is defined as the white noise enhancement (WNE). This phenomenon is evaluated as an interesting electrophysiological finding from the viewpoint of binaural interaction and in this study, its dynamic specifications were investigated. After the beginning of ipsilateral CWN, significant WNE was observed at 275th ms and it reached to a maximum, with an increase more than 40%, at 350th ms. After a habituation occurred, WNE reached to 20% on the 4th second by gradually decreasing and came to a steady state. In the time window between 2 and 5 ms after CWN started, a surprising amplitude decrease is observed. Therefore, CWN causes an effect, like a click, in the short-term and this on-response type effect originates from low level binaural centers, which decreases the MLR amplitude. However, the same CWN increases the MLR amplitude (WNE) by the effects over the high level binaural centers in the succeeding period, by its continuous characteristic.