RESUMO
By using orthogonal tests, the optimized extraction of volatile oil was practiced by distillation. The inclusion compound of the oil-beta-cyclodextrin inclusion compound was prepared by the liquid-phase method in aqueous solution. And it was confirmed by thin layer chromatogram and differential thermal analysis.
Assuntos
Óleos Voláteis/administração & dosagem , Plantas Medicinais/química , Zingiber officinale/química , beta-Ciclodextrinas , Cromatografia em Camada Fina , Ciclodextrinas , Análise Diferencial Térmica , Portadores de Fármacos , Estabilidade de Medicamentos , Medicamentos de Ervas Chinesas/administração & dosagem , Medicamentos de Ervas Chinesas/isolamento & purificação , Óleos Voláteis/isolamento & purificação , Rizoma/química , Tecnologia Farmacêutica/métodosRESUMO
A HPLC method has been used for the determination of paeonol in Jiawei Xiaoyao Granules. The method is simple and accurate. The average recovery is 96.48% and relative standard deviation 1.11%. The method can be used for quantitative analysis of these granules.
Assuntos
Acetofenonas/análise , Medicamentos de Ervas Chinesas/química , Cromatografia Líquida de Alta Pressão , Combinação de MedicamentosRESUMO
The optimun extraction process were selected from three extraction methods according to the content of paeonol and it UV characters. Futhermore, the conditions of extraction process selected were studied with orthogonal test. The result showed that the yield of paeonol is 73.7%, RSD 2.93% (n = 3).
Assuntos
Acetofenonas/isolamento & purificação , Medicamentos de Ervas Chinesas/isolamento & purificação , Paeonia/química , Acetofenonas/análise , Álcoois , Imersão , Plantas Medicinais/química , Cloreto de Sódio/química , Espectrofotometria Ultravioleta , Tecnologia Farmacêutica/métodosRESUMO
The geniposide and paeoniflorin in Jiaowei Xiaoyao Pills were separated and determined by HPLC, with a C18 column and a mixture of CH3CN-0.1% H3PO4(13:87) as mobile phase. The method is simple, rapid and accurate. The components have a good linearity, and the average recovery with RSD(n = 5) is 101.81% + 2.38% for geniposide and 98.75% + 1.95% for paeoniflorin.
Assuntos
Benzoatos , Hidrocarbonetos Aromáticos com Pontes , Medicamentos de Ervas Chinesas/química , Glucosídeos , Iridoides , Piranos , Cromatografia Líquida de Alta Pressão , Combinação de Medicamentos , Glucosídeos/análise , Glucosídeos/isolamento & purificação , Monoterpenos , Piranos/análise , Piranos/isolamento & purificação , Controle de QualidadeRESUMO
When Rhodiola sachalinensis polysaccharides A and B (RSP A and RSP B) were intraperitoneally injected to mice at dosages of 50 mg/kg and 100 mg/kg, the result showed that RSP B was the effective hypoglycemic ingredient of Rhodiola sachalinensis. When mice were administrated in different ways, it was shown that RSP B did not possess significant hypoglycemic effect through absorption in the instestines. However, RSP B does possess significant hypoglycemic effect if administrated subcutaneously, intramuscularly, intraperitoneally and intravenously.
Assuntos
Glicemia/metabolismo , Medicamentos de Ervas Chinesas/farmacologia , Hipoglicemiantes/farmacologia , Polissacarídeos/farmacologia , Animais , Medicamentos de Ervas Chinesas/administração & dosagem , Medicamentos de Ervas Chinesas/química , Feminino , Hipoglicemiantes/administração & dosagem , Magnoliopsida/química , Masculino , Camundongos , Polissacarídeos/administração & dosagem , Ratos , Ratos WistarRESUMO
Rhodiola sachalinensis polysaccharides (RSP) isolated from the root of Rhodiola sachalinensis was demonstrated to decrease the levels of blood sugar, liver glycogen and total blood lipid when injected peritoneally to mice at 50, 100 and 200 mg/kg once or for 7 successive days. In addition, RSP was found to decrease blood sugar and total blood lipid in various experimental hyperglycemias induced by injection of adrenaline, glucose and alloxan in mice. RSP exhibit inhibiting effect on the glycogen enhancement induced by glucose as well as strenghtening effect on the glycogen decomposition induced by adrenaline and alloxan.