RESUMO
A new bilobalide isomer (1), together with two flavonol glycosides (2, 3), have been isolated and elucidated from the extract of Ginkgo biloba leaves. Significantly, 1 was a new sesquiterpene lactone with two lactone ring groups, both 2 and 3 were two flavonol glycosides with a same cis-coumaroylated fragment. Their chemical structures were elucidated by NMR and MS spectroscopic date and the absolute configuration of 1 was specific established by Cu-Kα X-ray crystallographic analyses. However, 1-3 showed no obvious anti-platelet aggregation activity.
Assuntos
Bilobalídeos/isolamento & purificação , Flavonóis/isolamento & purificação , Ginkgo biloba/química , Glicosídeos/isolamento & purificação , Bilobalídeos/química , Ciclopentanos/química , Ciclopentanos/isolamento & purificação , Flavonóis/química , Furanos/química , Furanos/isolamento & purificação , Ginkgolídeos/química , Ginkgolídeos/isolamento & purificação , Glicosídeos/química , Folhas de Planta/químicaRESUMO
Three rare squiterpene lactone dimers lineariifolianoids M-O (1-3) were isolated from Inula lineariifolia for the first time. Their structures and absolute configuration were established on the basis of by NMR and MS spectroscopic data and X-ray crystallography. Furthermore, those three compounds exhibited significant inhibitory activity against LPS-induced NO production in RAW 264.7 macrophages with IC50 values of 1.421, 1.087 and 1.243 µM, respectively.