1.
Bioorg Med Chem Lett
; 14(17): 4539-44, 2004 Sep 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15357988
RESUMO
Syntheses and evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin-2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity.