1.
J Pharmacol Methods
; 7(2): 133-7, 1982 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7098495
RESUMO
A simple method is described for screening monoamine oxidase (MAO) inhibitors for preferential action on either type A or type B MAO. Kynuramine, a substrate for both types of MAO, was used and the sources of enzyme were rat heart (type A) and mouse heart (type B). The method clearly showed that clorgyline (a preferential type A inhibitor) preferentially inhibited rat heart MAO; whereas pargyline (a preferential type B inhibitor) preferentially inhibited mouse heart MAO. Pheniprazine, an inhibitor without type preference, was equally effective in the two tissues. The method was used to substantiate a report by others that amphetamine has preferential inhibitory action against type A MAO.
Assuntos
Avaliação Pré-Clínica de Medicamentos/métodos , Inibidores da Monoaminoxidase/farmacologia , Animais , Feminino , Cinuramina/metabolismo , Camundongos , Camundongos Endogâmicos ICR , Monoaminoxidase/análise , Miocárdio/enzimologia , Ratos
2.
J Pharmacol Exp Ther
; 179(1): 15-9, 1971 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-4938135
Assuntos
Gânglios da Base/metabolismo , Metaraminol/metabolismo , Fenetilaminas/metabolismo , Animais , Transporte Biológico Ativo , Depressão Química , Desipramina/farmacologia , Dopamina/biossíntese , Hipotálamo/metabolismo , Técnicas In Vitro , Neurônios/metabolismo , Octopamina/metabolismo , Concentração Osmolar , Ouabaína/farmacologia , Coelhos , Ratos , Reserpina/farmacologia , Sódio/fisiologia , Tiramina/metabolismo
3.
J Pharmacol Exp Ther
; 179(1): 10-4, 1971 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-4398538