RESUMO
In vitro experiments showed that calcium pectate added to the culture medium produces a dose-dependent prebiotic effect on lacto-and bifidobacteria cultures and on non-pathogenic strain of Escherichia coli. Calcium pectate produced a pronounced bacteriostatic effect on Candida albicans strain; the effects was more pronounced in a concentration of 4%.
Assuntos
Pectinas/farmacologia , Polissacarídeos/farmacologia , Anti-Infecciosos/farmacologia , Bifidobacterium/efeitos dos fármacos , Candida albicans/efeitos dos fármacos , Escherichia coli/efeitos dos fármacosRESUMO
Antiinflammatory (antiexudative, antiproliferative) activity of calcium pectate was revealed by tests on the mice leg carrageenan-induced edema and cotton-ball granuloma models. It was also established that this polysaccharide produced an anesthetic effect comparable with that of indomethacin on the model of acetate-induced convulsions in mice.
Assuntos
Anestésicos/farmacologia , Anti-Inflamatórios não Esteroides/farmacologia , Edema/tratamento farmacológico , Granuloma/tratamento farmacológico , Pectinas/farmacologia , Animais , Carragenina/toxicidade , Edema/induzido quimicamente , Feminino , Granuloma/induzido quimicamente , Indometacina/farmacologia , Camundongos , Ratos , Ratos WistarRESUMO
Standard models of experimental ulceration (of neurogenic origin, H. Shay ulcer, indomethacine-, ethanol-, prednisolone-, histamine- and acetate-induced ulcers) were used to demonstrate protective effect of non-starch polysaccharides (potassium alginate, potassium pectate, low-esterified pectin). Potassium pectate proved to be the most efficacious protector. Mechanism of its anti-ulcerative action is attributable to antacidic, cytoprotective, and reparative activity. It appeals to optimally stimulate the motor-evacuation function and, besides, exhibits marked anti-inflammatory activity.
Assuntos
Alginatos/uso terapêutico , Materiais Biocompatíveis/uso terapêutico , Esvaziamento Gástrico/efeitos dos fármacos , Pectinas/uso terapêutico , Polissacarídeos/uso terapêutico , Úlcera Gástrica/tratamento farmacológico , Administração Oral , Alginatos/administração & dosagem , Animais , Antidiarreicos/administração & dosagem , Antidiarreicos/uso terapêutico , Materiais Biocompatíveis/administração & dosagem , Modelos Animais de Doenças , Portadores de Fármacos , Feminino , Ácido Glucurônico/administração & dosagem , Ácido Glucurônico/uso terapêutico , Ácidos Hexurônicos/administração & dosagem , Ácidos Hexurônicos/uso terapêutico , Masculino , Camundongos , Pectinas/administração & dosagem , Polissacarídeos/administração & dosagem , Ratos , Ratos Wistar , Úlcera Gástrica/fisiopatologia , Resultado do TratamentoRESUMO
Calcium pectate has been found to exhibit an antiulcer activity in rats with model of chronic ulcers. Course treatment of the experimental animals with calcium pectate (i) accelerated the repair of experimental damage due to better integrity and higher secretory activity of epithelium and (ii) decreased hemodynamic disorders in surrounding mucous and epithelial membranes. The maximum effect, which was achieved with calcium pectate in a dose of 50 mg/kg, exceeded the action of the reference drug maalox on both 14th and 21st days of experiment.
Assuntos
Antiulcerosos/uso terapêutico , Mucosa Gástrica/efeitos dos fármacos , Pectinas/uso terapêutico , Úlcera Gástrica/tratamento farmacológico , Acetatos , Hidróxido de Alumínio/uso terapêutico , Animais , Doença Crônica , Modelos Animais de Doenças , Combinação de Medicamentos , Mucosa Gástrica/patologia , Hidróxido de Magnésio/uso terapêutico , Masculino , Ratos , Ratos Wistar , Úlcera Gástrica/induzido quimicamente , Úlcera Gástrica/patologiaRESUMO
Course prophylactic administration and single therapeutic treatment with calcium pectate improved resistance of rat gastroduodenal mucosa to ethanol-induced ulcers, prednisolone-induced ulcers, and H. Shay ulceration of the gastric mucosa.
Assuntos
Mucosa Gástrica/efeitos dos fármacos , Pectinas/farmacologia , Úlcera Péptica/tratamento farmacológico , Animais , Antiulcerosos/farmacologia , Antiulcerosos/uso terapêutico , Etanol , Feminino , Mucosa Gástrica/patologia , Mucosa Intestinal/efeitos dos fármacos , Mucosa Intestinal/patologia , Masculino , Pectinas/uso terapêutico , Úlcera Péptica/induzido quimicamente , Ratos , Resultado do TratamentoRESUMO
Both chronic (prophylactic) and single administration of standardized calcium pectate considerably increased the resistance of rat stomach mucous membrane with respect to ulcerogenic factors of various etiology, including immobilized stress, indomethacin, ethanol, prednizolone, and histamine, according to H. Shay's model. The gastroprotective effect of this polysaccharide was comparable with or exceeded the action of famotidine, sea buckthorn oil, and maalox.
Assuntos
Antiulcerosos/uso terapêutico , Pectinas/uso terapêutico , Úlcera Gástrica/prevenção & controle , Animais , Feminino , Mucosa Gástrica/efeitos dos fármacos , Mucosa Gástrica/patologia , Masculino , Camundongos , Ratos , Ratos Wistar , Úlcera Gástrica/etiologia , Úlcera Gástrica/patologiaRESUMO
It is established that cichorium root extract therapy leads to normalization of some morphofunctional liver features (decreases glycogen content and cell of necrosis and increases the number of cells with pronounced protein synthesis activity) in rats with CCl4-induced hepatitis.