A new xanthone glycoside from Pyrrosia sheareri.

A new xanthone glycoside, 3,5,7,8-tetramethoxyxanthone-1-O-ß-D-glucopyranoside (1), along with five known compounds, mangiferin (2), kaempferol (3), quercetin (4), chlorogenic acid (5) and diploptene (6), was isolated from the whole plants of Pyrrosia sheareri (Bak.) Ching. The structure of compound 1 was established on the basis of extensive spectroscopic analyses and chemical methods.

Serum and Liver Tissue Metabonomic Study on Fatty Liver in Rats Induced by High-Fat Diet and Intervention Effects of Traditional Chinese Medicine Qushi Huayu Decoction.

Qushi Huayu Decoction (QSHY), clinically derived, consists of five crude drugs, commonly used in treating fatty liver in a clinical setting. However, little is known about its metabolomics study. Herein, the serum and liver tissue metabolomics approach, based on gas chromatography coupled to spectrometry (GC/MS), was employed to evaluate the efficacy and the mechanism underlying QSHY in a rat model of high-fat diet-induced fatty liver. With pattern recognition analysis of serum and liver tissue metabolite profile, a clear separation of model group and control group was acquired for serum and liver tissue samples, respectively. The QSHY group showed a predisposition towards recovery mimicking the control group, which was in agreement with the biochemical alterations and histological results. 23 candidate biomarkers were identified in the serum and liver tissue samples that were utilized for exploring the underlying mechanism. The present study suggests that QSHY has significant anti-fatty liver effects on high-fat diet-induced fatty liver in rats, which might be attributed to regulating the dysfunction of beta-alanine metabolism, alanine, aspartate, and glutamate metabolism, glycine, serine, and threonine metabolism, pyruvate metabolism, and citrate cycle. Thus, metabolomics is a useful tool in the evaluation of the efficacy and elucidation of the mechanism underlying the complex traditional Chinese medicine prescriptions.

[A meta-analysis on effectiveness of acupuncture and moxibustion for chronic pelvic inflammatory disease].

OBJECTIVE: To evaluate the clinical effect of acupuncture and moxibustion therapies for chronic pelvic inflammatory disease (CPID) by Meta-analysis. METHODS: Randomized controlled trials of acupuncture and moxibustion in the treatment of CPID were searched from Databases of China National Knowledge Infrastructure (CNKI), Chinese Scientific and Technological Journals (VIP), WanFang, China Biomedicine (CBM) and PubMed up to 15 October, 2012. Two researchers independently selected the eligible literature according to the designed selection and exclusion criteria, extracted data and made an evaluation on the quality of the included studies by using the Jadad 5-point scale. The Meta-analysis was carried out using software Stata 11.0. RESULTS: A total of 26 studies involving 2 280 patients were included. Results of Meta-analysis showed significant differences between acupuncture-moxibustion intervention group and control group in terms of total effective rate [OR = 5.63, 95% CI (4.24, 7.47), P < 0.0001], cure rate [OR = 3.18, 95% CI (2.59, 3.89), P < 0.0001], and recurrence rate [OR = 0.11, 95% CI (0.03, 0.47), P < 0.05]. CONCLUSION: Acupuncture-moxibustion is effective in the treatment of CPID. Due to the Jadad scores of these included studies are low, high quality studies are definitely needed to confirm the conclusion.